Clinic, Anthropometric And Metabolic Changes In Adults With Class III Obesity Classified As Metabolically Healthy And Metabolically Unhealthy

Ligiane M Loureiro,1–3 Adryana Cordeiro,3,4 Rodrigo Mendes,5 Mariana Luna,3 Sílvia Pereira,3,6 Carlos J Saboya,3,6 Andrea Ramalho3,7 1Postgraduate Program, Doctorate in Nutritional Sciences, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil; 2Health Sciences In...

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Autores principales:	Loureiro LM, Cordeiro A, Mendes R, Luna M, Pereira S, Saboya CJ, Ramalho A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	obese phenotype bone markers inflammatory markers Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/18c570cca6f7426cad28bd2bcd9d9039
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spelling	oai:doaj.org-article:18c570cca6f7426cad28bd2bcd9d90392021-12-02T06:42:52ZClinic, Anthropometric And Metabolic Changes In Adults With Class III Obesity Classified As Metabolically Healthy And Metabolically Unhealthy1178-7007https://doaj.org/article/18c570cca6f7426cad28bd2bcd9d90392019-11-01T00:00:00Zhttps://www.dovepress.com/clinic-anthropometric-and-metabolic-changes-in-adults-with-class-iii-o-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Ligiane M Loureiro,1–3 Adryana Cordeiro,3,4 Rodrigo Mendes,5 Mariana Luna,3 Sílvia Pereira,3,6 Carlos J Saboya,3,6 Andrea Ramalho3,7 1Postgraduate Program, Doctorate in Nutritional Sciences, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil; 2Health Sciences Institute, Faculty of Nutrition, Federal University of Pará (UFPA), Belém, Brazil; 3Center for Research on Micronutrients (NPqM), Institute of Nutrition Josué de Castro of UFRJ, Rio de Janeiro, Brazil; 4Biomedicine Department, Biochemistry Unit, Faculty of Medicine, University of Porto, Porto, Portugal; 5Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro, Brazil; 6Multidisciplinary Center for Bariatric and Metabolic Surgery, Rio de Janeiro, Brazil; 7Department of Social and Applied Nutrition of the Institute of Nutrition, UFRJ, Rio de Janeiro, BrazilCorrespondence: Adryana CordeiroUniversity of Porto, Alameda Prof. Hernâni Monteiro, Porto 4200-319, PortugalTel +55-091-98171-5886Fax +351 22 551 3600Email cordeiroadryana@gmail.com   Ligiane M LoureiroFederal University of Rio de Janeiro, Av. Carlos Chagas Filho, 373, Cidade Universitária, Rio de Janeiro, RJ, BrazilTel +55-091-98171-5886Email liginutri@gmail.comPurpose: To describe clinical, biochemical and anthropometric profiles in adults with class III obesity classified as metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUHO).Patients and methods: This is a cross-sectional study with patients classified as MHO and MUHO according to the NCEP-ATP III. Anthropometric, biochemical and clinical variables were analyzed.Results: A total of 223 subjects were evaluated and 32.73% were classified as MHO and 67.26% as MUHO, respectively. The insulin resistance homeostasis model (HOMA-IR) showed elevation in the MUHO group (p=0.003) and anthropometric variables were correlated with bone markers [body index mass (BMI) vs phosphorus: r=0.31, p<0.001; BMI vs 25(OH)D: r=−0.31, p=0.041]. Visceral adiposity index was lower in MHO (p=0.001). Negative correlations between inflammatory markers and bone markers were observed in the MHO group (calcium vs C-reactive protein: −0.30, p=0.017; parathyroid hormone vs HOMA-IR: r=−0.28, p=0.017.Conclusion: MHO individuals showed important metabolic changes, such as those observed in MUHO, despite lower prevalence and severity. Continuous monitoring of these individuals is suggested, given the transient nature of the MHO phenotype.Keywords: obese, phenotype, bone markers, inflammatory markersLoureiro LMCordeiro AMendes RLuna MPereira SSaboya CJRamalho ADove Medical Pressarticleobesephenotypebone markersinflammatory markersSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 2419-2431 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	obese phenotype bone markers inflammatory markers Specialties of internal medicine RC581-951
spellingShingle	obese phenotype bone markers inflammatory markers Specialties of internal medicine RC581-951 Loureiro LM Cordeiro A Mendes R Luna M Pereira S Saboya CJ Ramalho A Clinic, Anthropometric And Metabolic Changes In Adults With Class III Obesity Classified As Metabolically Healthy And Metabolically Unhealthy
description	Ligiane M Loureiro,1–3 Adryana Cordeiro,3,4 Rodrigo Mendes,5 Mariana Luna,3 Sílvia Pereira,3,6 Carlos J Saboya,3,6 Andrea Ramalho3,7 1Postgraduate Program, Doctorate in Nutritional Sciences, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil; 2Health Sciences Institute, Faculty of Nutrition, Federal University of Pará (UFPA), Belém, Brazil; 3Center for Research on Micronutrients (NPqM), Institute of Nutrition Josué de Castro of UFRJ, Rio de Janeiro, Brazil; 4Biomedicine Department, Biochemistry Unit, Faculty of Medicine, University of Porto, Porto, Portugal; 5Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro, Brazil; 6Multidisciplinary Center for Bariatric and Metabolic Surgery, Rio de Janeiro, Brazil; 7Department of Social and Applied Nutrition of the Institute of Nutrition, UFRJ, Rio de Janeiro, BrazilCorrespondence: Adryana CordeiroUniversity of Porto, Alameda Prof. Hernâni Monteiro, Porto 4200-319, PortugalTel +55-091-98171-5886Fax +351 22 551 3600Email cordeiroadryana@gmail.com   Ligiane M LoureiroFederal University of Rio de Janeiro, Av. Carlos Chagas Filho, 373, Cidade Universitária, Rio de Janeiro, RJ, BrazilTel +55-091-98171-5886Email liginutri@gmail.comPurpose: To describe clinical, biochemical and anthropometric profiles in adults with class III obesity classified as metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUHO).Patients and methods: This is a cross-sectional study with patients classified as MHO and MUHO according to the NCEP-ATP III. Anthropometric, biochemical and clinical variables were analyzed.Results: A total of 223 subjects were evaluated and 32.73% were classified as MHO and 67.26% as MUHO, respectively. The insulin resistance homeostasis model (HOMA-IR) showed elevation in the MUHO group (p=0.003) and anthropometric variables were correlated with bone markers [body index mass (BMI) vs phosphorus: r=0.31, p<0.001; BMI vs 25(OH)D: r=−0.31, p=0.041]. Visceral adiposity index was lower in MHO (p=0.001). Negative correlations between inflammatory markers and bone markers were observed in the MHO group (calcium vs C-reactive protein: −0.30, p=0.017; parathyroid hormone vs HOMA-IR: r=−0.28, p=0.017.Conclusion: MHO individuals showed important metabolic changes, such as those observed in MUHO, despite lower prevalence and severity. Continuous monitoring of these individuals is suggested, given the transient nature of the MHO phenotype.Keywords: obese, phenotype, bone markers, inflammatory markers
format	article
author	Loureiro LM Cordeiro A Mendes R Luna M Pereira S Saboya CJ Ramalho A
author_facet	Loureiro LM Cordeiro A Mendes R Luna M Pereira S Saboya CJ Ramalho A
author_sort	Loureiro LM
title	Clinic, Anthropometric And Metabolic Changes In Adults With Class III Obesity Classified As Metabolically Healthy And Metabolically Unhealthy
title_short	Clinic, Anthropometric And Metabolic Changes In Adults With Class III Obesity Classified As Metabolically Healthy And Metabolically Unhealthy
title_full	Clinic, Anthropometric And Metabolic Changes In Adults With Class III Obesity Classified As Metabolically Healthy And Metabolically Unhealthy
title_fullStr	Clinic, Anthropometric And Metabolic Changes In Adults With Class III Obesity Classified As Metabolically Healthy And Metabolically Unhealthy
title_full_unstemmed	Clinic, Anthropometric And Metabolic Changes In Adults With Class III Obesity Classified As Metabolically Healthy And Metabolically Unhealthy
title_sort	clinic, anthropometric and metabolic changes in adults with class iii obesity classified as metabolically healthy and metabolically unhealthy
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/18c570cca6f7426cad28bd2bcd9d9039
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Clinic, Anthropometric And Metabolic Changes In Adults With Class III Obesity Classified As Metabolically Healthy And Metabolically Unhealthy

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