Integrating mass spectrometry with MD simulations reveals the role of lipids in Na+/H+ antiporters

Na+/H+antiporters transport sodium or lithium ions across the membrane in exchange for protons. Here the authors combine ion mobility mass spectrometry and molecular dynamics simulations to uncover a facilitating role for lipids in the transport mechanism.

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Auteurs principaux:	Michael Landreh, Erik G. Marklund, Povilas Uzdavinys, Matteo T. Degiacomi, Mathieu Coincon, Joseph Gault, Kallol Gupta, Idlir Liko, Justin L. P. Benesch, David Drew, Carol V. Robinson
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/18c9b4bc2d6a40a58f92ba99e8020ab8
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spelling	oai:doaj.org-article:18c9b4bc2d6a40a58f92ba99e8020ab82021-12-02T14:42:08ZIntegrating mass spectrometry with MD simulations reveals the role of lipids in Na+/H+ antiporters10.1038/ncomms139932041-1723https://doaj.org/article/18c9b4bc2d6a40a58f92ba99e8020ab82017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms13993https://doaj.org/toc/2041-1723Na+/H+antiporters transport sodium or lithium ions across the membrane in exchange for protons. Here the authors combine ion mobility mass spectrometry and molecular dynamics simulations to uncover a facilitating role for lipids in the transport mechanism.Michael LandrehErik G. MarklundPovilas UzdavinysMatteo T. DegiacomiMathieu CoinconJoseph GaultKallol GuptaIdlir LikoJustin L. P. BeneschDavid DrewCarol V. RobinsonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael Landreh Erik G. Marklund Povilas Uzdavinys Matteo T. Degiacomi Mathieu Coincon Joseph Gault Kallol Gupta Idlir Liko Justin L. P. Benesch David Drew Carol V. Robinson Integrating mass spectrometry with MD simulations reveals the role of lipids in Na+/H+ antiporters
description	Na+/H+antiporters transport sodium or lithium ions across the membrane in exchange for protons. Here the authors combine ion mobility mass spectrometry and molecular dynamics simulations to uncover a facilitating role for lipids in the transport mechanism.
format	article
author	Michael Landreh Erik G. Marklund Povilas Uzdavinys Matteo T. Degiacomi Mathieu Coincon Joseph Gault Kallol Gupta Idlir Liko Justin L. P. Benesch David Drew Carol V. Robinson
author_facet	Michael Landreh Erik G. Marklund Povilas Uzdavinys Matteo T. Degiacomi Mathieu Coincon Joseph Gault Kallol Gupta Idlir Liko Justin L. P. Benesch David Drew Carol V. Robinson
author_sort	Michael Landreh
title	Integrating mass spectrometry with MD simulations reveals the role of lipids in Na+/H+ antiporters
title_short	Integrating mass spectrometry with MD simulations reveals the role of lipids in Na+/H+ antiporters
title_full	Integrating mass spectrometry with MD simulations reveals the role of lipids in Na+/H+ antiporters
title_fullStr	Integrating mass spectrometry with MD simulations reveals the role of lipids in Na+/H+ antiporters
title_full_unstemmed	Integrating mass spectrometry with MD simulations reveals the role of lipids in Na+/H+ antiporters
title_sort	integrating mass spectrometry with md simulations reveals the role of lipids in na+/h+ antiporters
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/18c9b4bc2d6a40a58f92ba99e8020ab8
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Integrating mass spectrometry with MD simulations reveals the role of lipids in Na+/H+ antiporters

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