Regional grey matter microstructural changes and volume loss according to disease duration in multiple sclerosis patients

Abstract The spatio-temporal characteristics of grey matter (GM) impairment in multiple sclerosis (MS) are poorly understood. We used a new surface-based diffusion MRI processing tool to investigate regional modifications of microstructure, and we quantified volume loss in GM in a cohort of patients...

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Autores principales:	Elisabeth Solana, Eloy Martinez-Heras, Victor Montal, Eduard Vilaplana, Elisabet Lopez-Soley, Joaquim Radua, Nuria Sola-Valls, Carmen Montejo, Yolanda Blanco, Irene Pulido-Valdeolivas, Maria Sepúlveda, Magi Andorra, Joan Berenguer, Pablo Villoslada, E. H. Martinez-Lapiscina, Ferran Prados, Albert Saiz, Juan Fortea, Sara Llufriu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/18cc28771beb4cfea741588cf1d4797e
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spelling	oai:doaj.org-article:18cc28771beb4cfea741588cf1d4797e2021-12-02T16:45:47ZRegional grey matter microstructural changes and volume loss according to disease duration in multiple sclerosis patients10.1038/s41598-021-96132-x2045-2322https://doaj.org/article/18cc28771beb4cfea741588cf1d4797e2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96132-xhttps://doaj.org/toc/2045-2322Abstract The spatio-temporal characteristics of grey matter (GM) impairment in multiple sclerosis (MS) are poorly understood. We used a new surface-based diffusion MRI processing tool to investigate regional modifications of microstructure, and we quantified volume loss in GM in a cohort of patients with MS classified into three groups according to disease duration. Additionally, we investigated the relationship between GM changes with disease severity. We studied 54 healthy controls and 247 MS patients classified regarding disease duration: MS1 (less than 5 years, n = 67); MS2 (5–15 years, n = 107); and MS3 (more than15 years, n = 73). We compared GM mean diffusivity (MD), fractional anisotropy (FA) and volume between groups, and estimated their clinical associations. Regional modifications in diffusion measures (MD and FA) and volume did not overlap early in the disease, and became widespread in later phases. We found higher MD in MS1 group, mainly in the temporal cortex, and volume reduction in deep GM and left precuneus. Additional MD changes were evident in cingulate and occipital cortices in the MS2 group, coupled to volume reductions in deep GM and parietal and frontal poles. Changes in MD and volume extended to more than 80% of regions in MS3 group. Conversely, increments in FA, with very low effect size, were observed in the parietal cortex and thalamus in MS1 and MS2 groups, and extended to the frontal lobe in the later group. MD and GM changes were associated with white matter lesion load and with physical and cognitive disability. Microstructural integrity loss and atrophy present differential spatial predominance early in MS and accrual over time, probably due to distinct pathogenic mechanisms that underlie tissue damage.Elisabeth SolanaEloy Martinez-HerasVictor MontalEduard VilaplanaElisabet Lopez-SoleyJoaquim RaduaNuria Sola-VallsCarmen MontejoYolanda BlancoIrene Pulido-ValdeolivasMaria SepúlvedaMagi AndorraJoan BerenguerPablo VillosladaE. H. Martinez-LapiscinaFerran PradosAlbert SaizJuan ForteaSara LlufriuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elisabeth Solana Eloy Martinez-Heras Victor Montal Eduard Vilaplana Elisabet Lopez-Soley Joaquim Radua Nuria Sola-Valls Carmen Montejo Yolanda Blanco Irene Pulido-Valdeolivas Maria Sepúlveda Magi Andorra Joan Berenguer Pablo Villoslada E. H. Martinez-Lapiscina Ferran Prados Albert Saiz Juan Fortea Sara Llufriu Regional grey matter microstructural changes and volume loss according to disease duration in multiple sclerosis patients
description	Abstract The spatio-temporal characteristics of grey matter (GM) impairment in multiple sclerosis (MS) are poorly understood. We used a new surface-based diffusion MRI processing tool to investigate regional modifications of microstructure, and we quantified volume loss in GM in a cohort of patients with MS classified into three groups according to disease duration. Additionally, we investigated the relationship between GM changes with disease severity. We studied 54 healthy controls and 247 MS patients classified regarding disease duration: MS1 (less than 5 years, n = 67); MS2 (5–15 years, n = 107); and MS3 (more than15 years, n = 73). We compared GM mean diffusivity (MD), fractional anisotropy (FA) and volume between groups, and estimated their clinical associations. Regional modifications in diffusion measures (MD and FA) and volume did not overlap early in the disease, and became widespread in later phases. We found higher MD in MS1 group, mainly in the temporal cortex, and volume reduction in deep GM and left precuneus. Additional MD changes were evident in cingulate and occipital cortices in the MS2 group, coupled to volume reductions in deep GM and parietal and frontal poles. Changes in MD and volume extended to more than 80% of regions in MS3 group. Conversely, increments in FA, with very low effect size, were observed in the parietal cortex and thalamus in MS1 and MS2 groups, and extended to the frontal lobe in the later group. MD and GM changes were associated with white matter lesion load and with physical and cognitive disability. Microstructural integrity loss and atrophy present differential spatial predominance early in MS and accrual over time, probably due to distinct pathogenic mechanisms that underlie tissue damage.
format	article
author	Elisabeth Solana Eloy Martinez-Heras Victor Montal Eduard Vilaplana Elisabet Lopez-Soley Joaquim Radua Nuria Sola-Valls Carmen Montejo Yolanda Blanco Irene Pulido-Valdeolivas Maria Sepúlveda Magi Andorra Joan Berenguer Pablo Villoslada E. H. Martinez-Lapiscina Ferran Prados Albert Saiz Juan Fortea Sara Llufriu
author_facet	Elisabeth Solana Eloy Martinez-Heras Victor Montal Eduard Vilaplana Elisabet Lopez-Soley Joaquim Radua Nuria Sola-Valls Carmen Montejo Yolanda Blanco Irene Pulido-Valdeolivas Maria Sepúlveda Magi Andorra Joan Berenguer Pablo Villoslada E. H. Martinez-Lapiscina Ferran Prados Albert Saiz Juan Fortea Sara Llufriu
author_sort	Elisabeth Solana
title	Regional grey matter microstructural changes and volume loss according to disease duration in multiple sclerosis patients
title_short	Regional grey matter microstructural changes and volume loss according to disease duration in multiple sclerosis patients
title_full	Regional grey matter microstructural changes and volume loss according to disease duration in multiple sclerosis patients
title_fullStr	Regional grey matter microstructural changes and volume loss according to disease duration in multiple sclerosis patients
title_full_unstemmed	Regional grey matter microstructural changes and volume loss according to disease duration in multiple sclerosis patients
title_sort	regional grey matter microstructural changes and volume loss according to disease duration in multiple sclerosis patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/18cc28771beb4cfea741588cf1d4797e
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Regional grey matter microstructural changes and volume loss according to disease duration in multiple sclerosis patients

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