USE OF 20 MINUTE WHOLE BLOOD CLOTTING TIME IN PATIENTS OF SNAKEBITE; AN EXPERIENCE FROM KOHAT, KHYBER PAKHTUNKHAH

Objective: To study the diagnostic accuracy of 20-minute whole blood clotting time in hemotoxic snakebite. Study Design: Cross sectional validation study. Place and Duration of Study: Combined Military Hospital Kohat Pakistan, from Jul 2015 to Jun 2017. Methodology: Study included 52 patien...

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Autores principales:	Hammad Javed, Tariq Bashir, Atif Rauf, Syed Murtaza, Raja Jibran
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2021
Materias:	anti snake venom russel viper snakebite neurotoxic hemotoxic 20-minute whole blood clotting time Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/18cdb6460f904fbdb4036400be650ff8
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spelling	oai:doaj.org-article:18cdb6460f904fbdb4036400be650ff82021-11-18T04:56:24ZUSE OF 20 MINUTE WHOLE BLOOD CLOTTING TIME IN PATIENTS OF SNAKEBITE; AN EXPERIENCE FROM KOHAT, KHYBER PAKHTUNKHAH0030-96482411-8842https://doaj.org/article/18cdb6460f904fbdb4036400be650ff82021-10-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/3684/3587https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To study the diagnostic accuracy of 20-minute whole blood clotting time in hemotoxic snakebite. Study Design: Cross sectional validation study. Place and Duration of Study: Combined Military Hospital Kohat Pakistan, from Jul 2015 to Jun 2017. Methodology: Study included 52 patients who presented with the complaint of a snakebite. The data was recorded on predesigned proforma including clinical, laboratory features. All the patients were kept indoor for observation for a minimum of 72 hours from the time of presentation. Results: The study showed that males were more affected with age group between 20-50 years. Most common presenting features were local swelling 33 (71%) and pain and most common snakebite type was hemotoxic 33 (71%). The 20-minute whole blood clotting time was found to have low sensitivity (61%) and specificity (58%). A significant association was found between the dose of anti-snake venom and severity of coagulopathy (p<0.001), respiratory failure (p<0.001) and development of side effects due to anti snake venom (p<0.001). The mortality rate was 6.5% and was significantly related to age of the victims (p=0.003). The diagnostic accuracy of 20-minute whole blood clotting time was 60.25%. Conclusion: The use of 20-minute whole blood clotting time can not only be misleading but also a source of delay in administering anti snake venom given the low sensitivity and specificity and high false negative rate.Hammad JavedTariq BashirAtif RaufSyed MurtazaRaja JibranArmy Medical College Rawalpindiarticleanti snake venomrussel vipersnakebiteneurotoxichemotoxic20-minute whole blood clotting timeMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss 5, Pp 1619-1623 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anti snake venom russel viper snakebite neurotoxic hemotoxic 20-minute whole blood clotting time Medicine R Medicine (General) R5-920
spellingShingle	anti snake venom russel viper snakebite neurotoxic hemotoxic 20-minute whole blood clotting time Medicine R Medicine (General) R5-920 Hammad Javed Tariq Bashir Atif Rauf Syed Murtaza Raja Jibran USE OF 20 MINUTE WHOLE BLOOD CLOTTING TIME IN PATIENTS OF SNAKEBITE; AN EXPERIENCE FROM KOHAT, KHYBER PAKHTUNKHAH
description	Objective: To study the diagnostic accuracy of 20-minute whole blood clotting time in hemotoxic snakebite. Study Design: Cross sectional validation study. Place and Duration of Study: Combined Military Hospital Kohat Pakistan, from Jul 2015 to Jun 2017. Methodology: Study included 52 patients who presented with the complaint of a snakebite. The data was recorded on predesigned proforma including clinical, laboratory features. All the patients were kept indoor for observation for a minimum of 72 hours from the time of presentation. Results: The study showed that males were more affected with age group between 20-50 years. Most common presenting features were local swelling 33 (71%) and pain and most common snakebite type was hemotoxic 33 (71%). The 20-minute whole blood clotting time was found to have low sensitivity (61%) and specificity (58%). A significant association was found between the dose of anti-snake venom and severity of coagulopathy (p<0.001), respiratory failure (p<0.001) and development of side effects due to anti snake venom (p<0.001). The mortality rate was 6.5% and was significantly related to age of the victims (p=0.003). The diagnostic accuracy of 20-minute whole blood clotting time was 60.25%. Conclusion: The use of 20-minute whole blood clotting time can not only be misleading but also a source of delay in administering anti snake venom given the low sensitivity and specificity and high false negative rate.
format	article
author	Hammad Javed Tariq Bashir Atif Rauf Syed Murtaza Raja Jibran
author_facet	Hammad Javed Tariq Bashir Atif Rauf Syed Murtaza Raja Jibran
author_sort	Hammad Javed
title	USE OF 20 MINUTE WHOLE BLOOD CLOTTING TIME IN PATIENTS OF SNAKEBITE; AN EXPERIENCE FROM KOHAT, KHYBER PAKHTUNKHAH
title_short	USE OF 20 MINUTE WHOLE BLOOD CLOTTING TIME IN PATIENTS OF SNAKEBITE; AN EXPERIENCE FROM KOHAT, KHYBER PAKHTUNKHAH
title_full	USE OF 20 MINUTE WHOLE BLOOD CLOTTING TIME IN PATIENTS OF SNAKEBITE; AN EXPERIENCE FROM KOHAT, KHYBER PAKHTUNKHAH
title_fullStr	USE OF 20 MINUTE WHOLE BLOOD CLOTTING TIME IN PATIENTS OF SNAKEBITE; AN EXPERIENCE FROM KOHAT, KHYBER PAKHTUNKHAH
title_full_unstemmed	USE OF 20 MINUTE WHOLE BLOOD CLOTTING TIME IN PATIENTS OF SNAKEBITE; AN EXPERIENCE FROM KOHAT, KHYBER PAKHTUNKHAH
title_sort	use of 20 minute whole blood clotting time in patients of snakebite; an experience from kohat, khyber pakhtunkhah
publisher	Army Medical College Rawalpindi
publishDate	2021
url	https://doaj.org/article/18cdb6460f904fbdb4036400be650ff8
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USE OF 20 MINUTE WHOLE BLOOD CLOTTING TIME IN PATIENTS OF SNAKEBITE; AN EXPERIENCE FROM KOHAT, KHYBER PAKHTUNKHAH

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