Pancreatic Cancer and Platelets Crosstalk: A Potential Biomarker and Target

Platelets have been recognized as key players in hemostasis, thrombosis, and cancer. Preclinical and clinical researches evidenced that tumorigenesis and metastasis can be promoted by platelets through a wide variety of crosstalk between cancer cells and platelets. Pancreatic cancer is a devastating...

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Autores principales:	Shaoshan Mai, Iwona Inkielewicz-Stepniak
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	pancreatic cancer platelets TCIPA platelet-derived factors platelet extracellular vesicles angiogenesis Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/18d121b980d04384a0a39ab1768a9a75
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spelling	oai:doaj.org-article:18d121b980d04384a0a39ab1768a9a752021-11-10T07:29:29ZPancreatic Cancer and Platelets Crosstalk: A Potential Biomarker and Target2296-634X10.3389/fcell.2021.749689https://doaj.org/article/18d121b980d04384a0a39ab1768a9a752021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.749689/fullhttps://doaj.org/toc/2296-634XPlatelets have been recognized as key players in hemostasis, thrombosis, and cancer. Preclinical and clinical researches evidenced that tumorigenesis and metastasis can be promoted by platelets through a wide variety of crosstalk between cancer cells and platelets. Pancreatic cancer is a devastating disease with high morbidity and mortality worldwide. Although the relationship between pancreatic cancer and platelets in clinical diagnosis is described, the interplay between pancreatic cancer and platelets, the underlying pathological mechanism and pathways remain a matter of intensive study. This review summaries recent researches in connections between platelets and pancreatic cancer. The existing data showed different underlying mechanisms were involved in their complex crosstalk. Typically, pancreatic tumor accelerates platelet aggregation which forms thrombosis. Furthermore, extracellular vesicles released by platelets promote communication in a neoplastic microenvironment and illustrate how these interactions drive disease progression. We also discuss the advantages of novel model organoids in pancreatic cancer research. A more in-depth understanding of tumor and platelets crosstalk which is based on organoids and translational therapies may provide potential diagnostic and therapeutic strategies for pancreatic cancer progression.Shaoshan MaiIwona Inkielewicz-StepniakFrontiers Media S.A.articlepancreatic cancerplateletsTCIPAplatelet-derived factorsplatelet extracellular vesiclesangiogenesisBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pancreatic cancer platelets TCIPA platelet-derived factors platelet extracellular vesicles angiogenesis Biology (General) QH301-705.5
spellingShingle	pancreatic cancer platelets TCIPA platelet-derived factors platelet extracellular vesicles angiogenesis Biology (General) QH301-705.5 Shaoshan Mai Iwona Inkielewicz-Stepniak Pancreatic Cancer and Platelets Crosstalk: A Potential Biomarker and Target
description	Platelets have been recognized as key players in hemostasis, thrombosis, and cancer. Preclinical and clinical researches evidenced that tumorigenesis and metastasis can be promoted by platelets through a wide variety of crosstalk between cancer cells and platelets. Pancreatic cancer is a devastating disease with high morbidity and mortality worldwide. Although the relationship between pancreatic cancer and platelets in clinical diagnosis is described, the interplay between pancreatic cancer and platelets, the underlying pathological mechanism and pathways remain a matter of intensive study. This review summaries recent researches in connections between platelets and pancreatic cancer. The existing data showed different underlying mechanisms were involved in their complex crosstalk. Typically, pancreatic tumor accelerates platelet aggregation which forms thrombosis. Furthermore, extracellular vesicles released by platelets promote communication in a neoplastic microenvironment and illustrate how these interactions drive disease progression. We also discuss the advantages of novel model organoids in pancreatic cancer research. A more in-depth understanding of tumor and platelets crosstalk which is based on organoids and translational therapies may provide potential diagnostic and therapeutic strategies for pancreatic cancer progression.
format	article
author	Shaoshan Mai Iwona Inkielewicz-Stepniak
author_facet	Shaoshan Mai Iwona Inkielewicz-Stepniak
author_sort	Shaoshan Mai
title	Pancreatic Cancer and Platelets Crosstalk: A Potential Biomarker and Target
title_short	Pancreatic Cancer and Platelets Crosstalk: A Potential Biomarker and Target
title_full	Pancreatic Cancer and Platelets Crosstalk: A Potential Biomarker and Target
title_fullStr	Pancreatic Cancer and Platelets Crosstalk: A Potential Biomarker and Target
title_full_unstemmed	Pancreatic Cancer and Platelets Crosstalk: A Potential Biomarker and Target
title_sort	pancreatic cancer and platelets crosstalk: a potential biomarker and target
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/18d121b980d04384a0a39ab1768a9a75
work_keys_str_mv	AT shaoshanmai pancreaticcancerandplateletscrosstalkapotentialbiomarkerandtarget AT iwonainkielewiczstepniak pancreaticcancerandplateletscrosstalkapotentialbiomarkerandtarget
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Pancreatic Cancer and Platelets Crosstalk: A Potential Biomarker and Target

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