Tumor LDH-A expression and serum LDH status are two metabolic predictors for triple negative breast cancer brain metastasis

Abstract There are limited therapeutic methods for triple negative breast cancer in the clinic, which is easy to progress into the brain to form metastatic lesions and evolve into the terminal stage. Because both the primary cancer and the brain metastasis have high glycolysis, we hypothesize that l...

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Autores principales:	Tieying Dong, Zhaoliang Liu, Qijia Xuan, Zhuozhong Wang, Wenjie Ma, Qingyuan Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/18d8357cacd34779a33c7e8abce0070c
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spelling	oai:doaj.org-article:18d8357cacd34779a33c7e8abce0070c2021-12-02T16:06:21ZTumor LDH-A expression and serum LDH status are two metabolic predictors for triple negative breast cancer brain metastasis10.1038/s41598-017-06378-72045-2322https://doaj.org/article/18d8357cacd34779a33c7e8abce0070c2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06378-7https://doaj.org/toc/2045-2322Abstract There are limited therapeutic methods for triple negative breast cancer in the clinic, which is easy to progress into the brain to form metastatic lesions and evolve into the terminal stage. Because both the primary cancer and the brain metastasis have high glycolysis, we hypothesize that lactate dehydrogenase (LDH), which catalyzes the final step of glycolysis, may be a predictor, as well as a treatment target, for breast cancer brain metastasis. Therefore, the expression of LDH-A was detected on 119 triple negative breast cancer tissues with immunohistochemistry, and the serum LDH levels were also measured. Our results showed that the LDH-A expression inside the tumor was significantly higher than the matched normal tissues. Tumor LDH-A expression, serum LDH status, and the slope of serum LDH status were closely associated with triple negative breast cancer brain metastasis and brain metastasis free survival. This study indicates that tumor LDH and serum LDH status are two predictors for triple negative breast cancer brain metastasis.Tieying DongZhaoliang LiuQijia XuanZhuozhong WangWenjie MaQingyuan ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tieying Dong Zhaoliang Liu Qijia Xuan Zhuozhong Wang Wenjie Ma Qingyuan Zhang Tumor LDH-A expression and serum LDH status are two metabolic predictors for triple negative breast cancer brain metastasis
description	Abstract There are limited therapeutic methods for triple negative breast cancer in the clinic, which is easy to progress into the brain to form metastatic lesions and evolve into the terminal stage. Because both the primary cancer and the brain metastasis have high glycolysis, we hypothesize that lactate dehydrogenase (LDH), which catalyzes the final step of glycolysis, may be a predictor, as well as a treatment target, for breast cancer brain metastasis. Therefore, the expression of LDH-A was detected on 119 triple negative breast cancer tissues with immunohistochemistry, and the serum LDH levels were also measured. Our results showed that the LDH-A expression inside the tumor was significantly higher than the matched normal tissues. Tumor LDH-A expression, serum LDH status, and the slope of serum LDH status were closely associated with triple negative breast cancer brain metastasis and brain metastasis free survival. This study indicates that tumor LDH and serum LDH status are two predictors for triple negative breast cancer brain metastasis.
format	article
author	Tieying Dong Zhaoliang Liu Qijia Xuan Zhuozhong Wang Wenjie Ma Qingyuan Zhang
author_facet	Tieying Dong Zhaoliang Liu Qijia Xuan Zhuozhong Wang Wenjie Ma Qingyuan Zhang
author_sort	Tieying Dong
title	Tumor LDH-A expression and serum LDH status are two metabolic predictors for triple negative breast cancer brain metastasis
title_short	Tumor LDH-A expression and serum LDH status are two metabolic predictors for triple negative breast cancer brain metastasis
title_full	Tumor LDH-A expression and serum LDH status are two metabolic predictors for triple negative breast cancer brain metastasis
title_fullStr	Tumor LDH-A expression and serum LDH status are two metabolic predictors for triple negative breast cancer brain metastasis
title_full_unstemmed	Tumor LDH-A expression and serum LDH status are two metabolic predictors for triple negative breast cancer brain metastasis
title_sort	tumor ldh-a expression and serum ldh status are two metabolic predictors for triple negative breast cancer brain metastasis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/18d8357cacd34779a33c7e8abce0070c
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Tumor LDH-A expression and serum LDH status are two metabolic predictors for triple negative breast cancer brain metastasis

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