Synthesis, in-vivo anti-diabetic & anticancer activities and molecular modelling studies of tetrahydrobenzo[d]thiazole tethered nicotinohydrazide derivatives
A series of thirty new thiazole-pyridine derivatives were synthesized by reaction of 4,4,7,7-tetra-methyl-4,5,6,7-tetrahydrobenzo[d]thiazol-2-amine with 6-chloronicotinate followed by condensing with benzaldehydes and screened for their anti-diabetic activity by in vivo housing Swiss albino mice. Al...
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2022
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oai:doaj.org-article:18dfe7a566ba4233b6e4b7b7eb4b529c2021-11-28T04:29:34ZSynthesis, in-vivo anti-diabetic & anticancer activities and molecular modelling studies of tetrahydrobenzo[d]thiazole tethered nicotinohydrazide derivatives1878-535210.1016/j.arabjc.2021.103546https://doaj.org/article/18dfe7a566ba4233b6e4b7b7eb4b529c2022-02-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S187853522100561Xhttps://doaj.org/toc/1878-5352A series of thirty new thiazole-pyridine derivatives were synthesized by reaction of 4,4,7,7-tetra-methyl-4,5,6,7-tetrahydrobenzo[d]thiazol-2-amine with 6-chloronicotinate followed by condensing with benzaldehydes and screened for their anti-diabetic activity by in vivo housing Swiss albino mice. All synthesized compounds resulted in reducing the glucose level when compared with reference standard drug glibenclamide. In specific, compound 7 exhibited significant activity in terms of fasting blood glucose level reduction. In addition, the in-silico binding studies of the potential compounds 11f and 11g with human PPAR-γ protein complexed with Retinoid X Receptor (RXR) alpha Nuclear Receptor showed good interactions when compared to the standard drug Rosiglitazone. The newly synthesized drugs may be potential anti-diabetic drugs with possible specific actions.Suri Babu PatchipalaVisweswara Rao PasupuletiAmrutha V AudipudiHari babu BollikollaElsevierarticleTetrahydrothiazolePyridinehydrazideAnti-diabetic activityMolecular modelingChemistryQD1-999ENArabian Journal of Chemistry, Vol 15, Iss 2, Pp 103546- (2022) |
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DOAJ |
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DOAJ |
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EN |
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Tetrahydrothiazole Pyridinehydrazide Anti-diabetic activity Molecular modeling Chemistry QD1-999 |
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Tetrahydrothiazole Pyridinehydrazide Anti-diabetic activity Molecular modeling Chemistry QD1-999 Suri Babu Patchipala Visweswara Rao Pasupuleti Amrutha V Audipudi Hari babu Bollikolla Synthesis, in-vivo anti-diabetic & anticancer activities and molecular modelling studies of tetrahydrobenzo[d]thiazole tethered nicotinohydrazide derivatives |
| description |
A series of thirty new thiazole-pyridine derivatives were synthesized by reaction of 4,4,7,7-tetra-methyl-4,5,6,7-tetrahydrobenzo[d]thiazol-2-amine with 6-chloronicotinate followed by condensing with benzaldehydes and screened for their anti-diabetic activity by in vivo housing Swiss albino mice. All synthesized compounds resulted in reducing the glucose level when compared with reference standard drug glibenclamide. In specific, compound 7 exhibited significant activity in terms of fasting blood glucose level reduction. In addition, the in-silico binding studies of the potential compounds 11f and 11g with human PPAR-γ protein complexed with Retinoid X Receptor (RXR) alpha Nuclear Receptor showed good interactions when compared to the standard drug Rosiglitazone. The newly synthesized drugs may be potential anti-diabetic drugs with possible specific actions. |
| format |
article |
| author |
Suri Babu Patchipala Visweswara Rao Pasupuleti Amrutha V Audipudi Hari babu Bollikolla |
| author_facet |
Suri Babu Patchipala Visweswara Rao Pasupuleti Amrutha V Audipudi Hari babu Bollikolla |
| author_sort |
Suri Babu Patchipala |
| title |
Synthesis, in-vivo anti-diabetic & anticancer activities and molecular modelling studies of tetrahydrobenzo[d]thiazole tethered nicotinohydrazide derivatives |
| title_short |
Synthesis, in-vivo anti-diabetic & anticancer activities and molecular modelling studies of tetrahydrobenzo[d]thiazole tethered nicotinohydrazide derivatives |
| title_full |
Synthesis, in-vivo anti-diabetic & anticancer activities and molecular modelling studies of tetrahydrobenzo[d]thiazole tethered nicotinohydrazide derivatives |
| title_fullStr |
Synthesis, in-vivo anti-diabetic & anticancer activities and molecular modelling studies of tetrahydrobenzo[d]thiazole tethered nicotinohydrazide derivatives |
| title_full_unstemmed |
Synthesis, in-vivo anti-diabetic & anticancer activities and molecular modelling studies of tetrahydrobenzo[d]thiazole tethered nicotinohydrazide derivatives |
| title_sort |
synthesis, in-vivo anti-diabetic & anticancer activities and molecular modelling studies of tetrahydrobenzo[d]thiazole tethered nicotinohydrazide derivatives |
| publisher |
Elsevier |
| publishDate |
2022 |
| url |
https://doaj.org/article/18dfe7a566ba4233b6e4b7b7eb4b529c |
| work_keys_str_mv |
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