Spatiotemporal segregation of human marginal zone and memory B cell populations in lymphoid tissue
Human memory and marginal zone B cells share some features including CD27 expression and somatic hypermutation, but their lineage relationship is still unclear. Here the authors use mass cytometry and sequential clustering methods to show that, despite their shared features, memory and marginal zone...
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Nature Portfolio
2018
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oai:doaj.org-article:18e17622ab574decbfaad7cce6011bef2021-12-02T17:31:26ZSpatiotemporal segregation of human marginal zone and memory B cell populations in lymphoid tissue10.1038/s41467-018-06089-12041-1723https://doaj.org/article/18e17622ab574decbfaad7cce6011bef2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06089-1https://doaj.org/toc/2041-1723Human memory and marginal zone B cells share some features including CD27 expression and somatic hypermutation, but their lineage relationship is still unclear. Here the authors use mass cytometry and sequential clustering methods to show that, despite their shared features, memory and marginal zone B cells represent distinct lineage choices.Yuan ZhaoMohamed UdumanJacqueline H. Y. SiuThomas J. TullJeremy D. SandersonYu-Chang Bryan WuJulian Q. ZhouNedyalko PetrovRichard EllisKatrina ToddKonstantia-Maria ChaveleWilliam GuesdonAnna VossenkamperWayel JassemDavid P. D’CruzDavid J. FearSusan JohnDagmar Scheel-ToellnerClaire HopkinsEstefania MorenoNatalie L. WoodmanFrancesca CiccarelliSusanne HeckSteven H. KleinsteinMats BemarkJo SpencerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Yuan Zhao Mohamed Uduman Jacqueline H. Y. Siu Thomas J. Tull Jeremy D. Sanderson Yu-Chang Bryan Wu Julian Q. Zhou Nedyalko Petrov Richard Ellis Katrina Todd Konstantia-Maria Chavele William Guesdon Anna Vossenkamper Wayel Jassem David P. D’Cruz David J. Fear Susan John Dagmar Scheel-Toellner Claire Hopkins Estefania Moreno Natalie L. Woodman Francesca Ciccarelli Susanne Heck Steven H. Kleinstein Mats Bemark Jo Spencer Spatiotemporal segregation of human marginal zone and memory B cell populations in lymphoid tissue |
| description |
Human memory and marginal zone B cells share some features including CD27 expression and somatic hypermutation, but their lineage relationship is still unclear. Here the authors use mass cytometry and sequential clustering methods to show that, despite their shared features, memory and marginal zone B cells represent distinct lineage choices. |
| format |
article |
| author |
Yuan Zhao Mohamed Uduman Jacqueline H. Y. Siu Thomas J. Tull Jeremy D. Sanderson Yu-Chang Bryan Wu Julian Q. Zhou Nedyalko Petrov Richard Ellis Katrina Todd Konstantia-Maria Chavele William Guesdon Anna Vossenkamper Wayel Jassem David P. D’Cruz David J. Fear Susan John Dagmar Scheel-Toellner Claire Hopkins Estefania Moreno Natalie L. Woodman Francesca Ciccarelli Susanne Heck Steven H. Kleinstein Mats Bemark Jo Spencer |
| author_facet |
Yuan Zhao Mohamed Uduman Jacqueline H. Y. Siu Thomas J. Tull Jeremy D. Sanderson Yu-Chang Bryan Wu Julian Q. Zhou Nedyalko Petrov Richard Ellis Katrina Todd Konstantia-Maria Chavele William Guesdon Anna Vossenkamper Wayel Jassem David P. D’Cruz David J. Fear Susan John Dagmar Scheel-Toellner Claire Hopkins Estefania Moreno Natalie L. Woodman Francesca Ciccarelli Susanne Heck Steven H. Kleinstein Mats Bemark Jo Spencer |
| author_sort |
Yuan Zhao |
| title |
Spatiotemporal segregation of human marginal zone and memory B cell populations in lymphoid tissue |
| title_short |
Spatiotemporal segregation of human marginal zone and memory B cell populations in lymphoid tissue |
| title_full |
Spatiotemporal segregation of human marginal zone and memory B cell populations in lymphoid tissue |
| title_fullStr |
Spatiotemporal segregation of human marginal zone and memory B cell populations in lymphoid tissue |
| title_full_unstemmed |
Spatiotemporal segregation of human marginal zone and memory B cell populations in lymphoid tissue |
| title_sort |
spatiotemporal segregation of human marginal zone and memory b cell populations in lymphoid tissue |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/18e17622ab574decbfaad7cce6011bef |
| work_keys_str_mv |
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| _version_ |
1718380597615788032 |