COVID-19 in an immunocompromised host: persistent shedding of viable SARS-CoV-2 and emergence of multiple mutations: a case report

ABSTRACT: This article reports a case of a 21-year-old woman with refractory B-cell acute lymphocytic leukaemia who presented with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). She remained positive for SARS-CoV-2 by viral culture for 78 days and by polymerase chain reaction (PCR) fo...

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Autores principales:	Wayne F. Leung, Samuel Chorlton, John Tyson, Ghada N. Al-Rawahi, Agatha N. Jassem, Natalie Prystajecky, Shazia Masud, Gregory D. Deans, Michael G. Chapman, Yazdan Mirzanejad, Melanie C.M. Murray, Patrick H.P. Wong
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	SARS-CoV-2 Immunocompromised Sequencing Mutation Viral culture Case report Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/18e2e86402434a7bbe3b88b65ecdaad9
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spelling	oai:doaj.org-article:18e2e86402434a7bbe3b88b65ecdaad92021-12-04T04:33:20ZCOVID-19 in an immunocompromised host: persistent shedding of viable SARS-CoV-2 and emergence of multiple mutations: a case report1201-971210.1016/j.ijid.2021.10.045https://doaj.org/article/18e2e86402434a7bbe3b88b65ecdaad92022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1201971221008298https://doaj.org/toc/1201-9712ABSTRACT: This article reports a case of a 21-year-old woman with refractory B-cell acute lymphocytic leukaemia who presented with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). She remained positive for SARS-CoV-2 by viral culture for 78 days and by polymerase chain reaction (PCR) for 97 days. Sequencing of repeat samples over time demonstrated an increasing and dynamic repertoire of mutations.Wayne F. LeungSamuel ChorltonJohn TysonGhada N. Al-RawahiAgatha N. JassemNatalie PrystajeckyShazia MasudGregory D. DeansMichael G. ChapmanYazdan MirzanejadMelanie C.M. MurrayPatrick H.P. WongElsevierarticleSARS-CoV-2ImmunocompromisedSequencingMutationViral cultureCase reportInfectious and parasitic diseasesRC109-216ENInternational Journal of Infectious Diseases, Vol 114, Iss , Pp 178-182 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 Immunocompromised Sequencing Mutation Viral culture Case report Infectious and parasitic diseases RC109-216
spellingShingle	SARS-CoV-2 Immunocompromised Sequencing Mutation Viral culture Case report Infectious and parasitic diseases RC109-216 Wayne F. Leung Samuel Chorlton John Tyson Ghada N. Al-Rawahi Agatha N. Jassem Natalie Prystajecky Shazia Masud Gregory D. Deans Michael G. Chapman Yazdan Mirzanejad Melanie C.M. Murray Patrick H.P. Wong COVID-19 in an immunocompromised host: persistent shedding of viable SARS-CoV-2 and emergence of multiple mutations: a case report
description	ABSTRACT: This article reports a case of a 21-year-old woman with refractory B-cell acute lymphocytic leukaemia who presented with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). She remained positive for SARS-CoV-2 by viral culture for 78 days and by polymerase chain reaction (PCR) for 97 days. Sequencing of repeat samples over time demonstrated an increasing and dynamic repertoire of mutations.
format	article
author	Wayne F. Leung Samuel Chorlton John Tyson Ghada N. Al-Rawahi Agatha N. Jassem Natalie Prystajecky Shazia Masud Gregory D. Deans Michael G. Chapman Yazdan Mirzanejad Melanie C.M. Murray Patrick H.P. Wong
author_facet	Wayne F. Leung Samuel Chorlton John Tyson Ghada N. Al-Rawahi Agatha N. Jassem Natalie Prystajecky Shazia Masud Gregory D. Deans Michael G. Chapman Yazdan Mirzanejad Melanie C.M. Murray Patrick H.P. Wong
author_sort	Wayne F. Leung
title	COVID-19 in an immunocompromised host: persistent shedding of viable SARS-CoV-2 and emergence of multiple mutations: a case report
title_short	COVID-19 in an immunocompromised host: persistent shedding of viable SARS-CoV-2 and emergence of multiple mutations: a case report
title_full	COVID-19 in an immunocompromised host: persistent shedding of viable SARS-CoV-2 and emergence of multiple mutations: a case report
title_fullStr	COVID-19 in an immunocompromised host: persistent shedding of viable SARS-CoV-2 and emergence of multiple mutations: a case report
title_full_unstemmed	COVID-19 in an immunocompromised host: persistent shedding of viable SARS-CoV-2 and emergence of multiple mutations: a case report
title_sort	covid-19 in an immunocompromised host: persistent shedding of viable sars-cov-2 and emergence of multiple mutations: a case report
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/18e2e86402434a7bbe3b88b65ecdaad9
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COVID-19 in an immunocompromised host: persistent shedding of viable SARS-CoV-2 and emergence of multiple mutations: a case report

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