Next generation drug-eluting stents: focus on bioabsorbable platforms and polymers

Brendan Doyle, David R Holmes JrDivision of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USAAbstract: The success of drug-eluting stents in preventing restenosis has shifted the focus of new stent development toward enhancing long t...

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Autores principales:	Brendan Doyle, David R Holmes Jr
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/18e350afdaca42f8b0143b6cd0ee81d9
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spelling	oai:doaj.org-article:18e350afdaca42f8b0143b6cd0ee81d92021-12-02T00:10:37ZNext generation drug-eluting stents: focus on bioabsorbable platforms and polymers1179-1470https://doaj.org/article/18e350afdaca42f8b0143b6cd0ee81d92009-11-01T00:00:00Zhttp://www.dovepress.com/next-generation-drug-eluting-stents-focus-on-bioabsorbable-platforms-a-a3712https://doaj.org/toc/1179-1470Brendan Doyle, David R Holmes JrDivision of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USAAbstract: The success of drug-eluting stents in preventing restenosis has shifted the focus of new stent development toward enhancing long term safety and efficacy of these devices, while simultaneously eliminating the need for indefinite dual antiplatelet therapy. A technical advance fulfilling these aims would hold tremendous potential to reduce morbidity, mortality and economic costs associated with the percutaneous treatment of coronary artery disease. An attractive approach is the use of bioabsorbable stent designs. These may include stents with different bioabsorbable drugs, bioabsorbable polymers or even bioabsorbable metallic backbones. A device that could achieve excellent acute and long-term results, but disappear completely within months (thereby avoiding the need for prolonged dual antiplatelet therapy), would be a tremendous advance. Too good to be true? We explore here the scientific rationale and prospects for success with this exciting concept.Keywords: percutaneous coronary intervention, biodegradable, bioabsorbable, polymer, stent Brendan DoyleDavid R Holmes JrDove Medical PressarticleMedical technologyR855-855.5ENMedical Devices: Evidence and Research, Vol 2009, Iss default, Pp 47-55 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medical technology R855-855.5
spellingShingle	Medical technology R855-855.5 Brendan Doyle David R Holmes Jr Next generation drug-eluting stents: focus on bioabsorbable platforms and polymers
description	Brendan Doyle, David R Holmes JrDivision of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USAAbstract: The success of drug-eluting stents in preventing restenosis has shifted the focus of new stent development toward enhancing long term safety and efficacy of these devices, while simultaneously eliminating the need for indefinite dual antiplatelet therapy. A technical advance fulfilling these aims would hold tremendous potential to reduce morbidity, mortality and economic costs associated with the percutaneous treatment of coronary artery disease. An attractive approach is the use of bioabsorbable stent designs. These may include stents with different bioabsorbable drugs, bioabsorbable polymers or even bioabsorbable metallic backbones. A device that could achieve excellent acute and long-term results, but disappear completely within months (thereby avoiding the need for prolonged dual antiplatelet therapy), would be a tremendous advance. Too good to be true? We explore here the scientific rationale and prospects for success with this exciting concept.Keywords: percutaneous coronary intervention, biodegradable, bioabsorbable, polymer, stent
format	article
author	Brendan Doyle David R Holmes Jr
author_facet	Brendan Doyle David R Holmes Jr
author_sort	Brendan Doyle
title	Next generation drug-eluting stents: focus on bioabsorbable platforms and polymers
title_short	Next generation drug-eluting stents: focus on bioabsorbable platforms and polymers
title_full	Next generation drug-eluting stents: focus on bioabsorbable platforms and polymers
title_fullStr	Next generation drug-eluting stents: focus on bioabsorbable platforms and polymers
title_full_unstemmed	Next generation drug-eluting stents: focus on bioabsorbable platforms and polymers
title_sort	next generation drug-eluting stents: focus on bioabsorbable platforms and polymers
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/18e350afdaca42f8b0143b6cd0ee81d9
work_keys_str_mv	AT brendandoyle nextgenerationdrugelutingstentsfocusonbioabsorbableplatformsandpolymers AT davidrholmesjr nextgenerationdrugelutingstentsfocusonbioabsorbableplatformsandpolymers
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Next generation drug-eluting stents: focus on bioabsorbable platforms and polymers

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