L-Arginine-No System Participates in the Analgesic Effect of Flunixin Meglumine in the Rat

This study investigated whether the L-arginine-NO system participates in the analgesic effect of flunixin meglumine in the rat. Hyperalgesia was induced by intraplantar (i.pl.) administration of carrageenan (500 μg) into the rat’s hind paw. Electronic von Frey apparatus was used to determine paw wit...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Milovanović Mirjana, Vučković Sonja, Prostran Milica, Trailović Saša, Jovanović Milan
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2016
Materias:	flunixin meglumine l-name l-arginine carrageenan hyperalgesia Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/18e397a1d15a48dea99ea1fe1f8af128
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:18e397a1d15a48dea99ea1fe1f8af128
record_format	dspace
spelling	oai:doaj.org-article:18e397a1d15a48dea99ea1fe1f8af1282021-11-17T21:27:51ZL-Arginine-No System Participates in the Analgesic Effect of Flunixin Meglumine in the Rat1820-744810.1515/acve-2016-0008https://doaj.org/article/18e397a1d15a48dea99ea1fe1f8af1282016-03-01T00:00:00Zhttps://doi.org/10.1515/acve-2016-0008https://doaj.org/toc/1820-7448This study investigated whether the L-arginine-NO system participates in the analgesic effect of flunixin meglumine in the rat. Hyperalgesia was induced by intraplantar (i.pl.) administration of carrageenan (500 μg) into the rat’s hind paw. Electronic von Frey apparatus was used to determine paw withdrawal threshold induced by pressure as the painful stimulus, measured in grams (g). Flunixin meglumine (FM; 0.09-0.1 mg/kg; s.c.) and NG-nitro-L-arginine methyl ester (L-NAME; 10 mg/kg; i.p.), given separately as a pre-treatment, i.e. 15 min before i.pl. injection of carrageenan, produced a significant antinociception. When FM (0.09 mg/kg) and a sub-effective dose of L-NAME (5 mg/kg) were co-administered, the antinociceptive effect was significantly increased in comparison with the effect of FM alone. L-arginine (L-ARG;10 mg/kg; i.p.) itself did not produce significant effect on carrageenan-induced hyperalgesia, but significantly reduced the antinociceptive effects of both FM and FM + L-NAME combination. The inhibition of the production of NO might be involved in the mechanism of the analgesic effect of FM.Milovanović MirjanaVučković SonjaProstran MilicaTrailović SašaJovanović MilanSciendoarticleflunixin megluminel-namel-argininecarrageenanhyperalgesiaVeterinary medicineSF600-1100ENActa Veterinaria, Vol 66, Iss 1, Pp 103-114 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	flunixin meglumine l-name l-arginine carrageenan hyperalgesia Veterinary medicine SF600-1100
spellingShingle	flunixin meglumine l-name l-arginine carrageenan hyperalgesia Veterinary medicine SF600-1100 Milovanović Mirjana Vučković Sonja Prostran Milica Trailović Saša Jovanović Milan L-Arginine-No System Participates in the Analgesic Effect of Flunixin Meglumine in the Rat
description	This study investigated whether the L-arginine-NO system participates in the analgesic effect of flunixin meglumine in the rat. Hyperalgesia was induced by intraplantar (i.pl.) administration of carrageenan (500 μg) into the rat’s hind paw. Electronic von Frey apparatus was used to determine paw withdrawal threshold induced by pressure as the painful stimulus, measured in grams (g). Flunixin meglumine (FM; 0.09-0.1 mg/kg; s.c.) and NG-nitro-L-arginine methyl ester (L-NAME; 10 mg/kg; i.p.), given separately as a pre-treatment, i.e. 15 min before i.pl. injection of carrageenan, produced a significant antinociception. When FM (0.09 mg/kg) and a sub-effective dose of L-NAME (5 mg/kg) were co-administered, the antinociceptive effect was significantly increased in comparison with the effect of FM alone. L-arginine (L-ARG;10 mg/kg; i.p.) itself did not produce significant effect on carrageenan-induced hyperalgesia, but significantly reduced the antinociceptive effects of both FM and FM + L-NAME combination. The inhibition of the production of NO might be involved in the mechanism of the analgesic effect of FM.
format	article
author	Milovanović Mirjana Vučković Sonja Prostran Milica Trailović Saša Jovanović Milan
author_facet	Milovanović Mirjana Vučković Sonja Prostran Milica Trailović Saša Jovanović Milan
author_sort	Milovanović Mirjana
title	L-Arginine-No System Participates in the Analgesic Effect of Flunixin Meglumine in the Rat
title_short	L-Arginine-No System Participates in the Analgesic Effect of Flunixin Meglumine in the Rat
title_full	L-Arginine-No System Participates in the Analgesic Effect of Flunixin Meglumine in the Rat
title_fullStr	L-Arginine-No System Participates in the Analgesic Effect of Flunixin Meglumine in the Rat
title_full_unstemmed	L-Arginine-No System Participates in the Analgesic Effect of Flunixin Meglumine in the Rat
title_sort	l-arginine-no system participates in the analgesic effect of flunixin meglumine in the rat
publisher	Sciendo
publishDate	2016
url	https://doaj.org/article/18e397a1d15a48dea99ea1fe1f8af128
work_keys_str_mv	AT milovanovicmirjana largininenosystemparticipatesintheanalgesiceffectofflunixinmeglumineintherat AT vuckovicsonja largininenosystemparticipatesintheanalgesiceffectofflunixinmeglumineintherat AT prostranmilica largininenosystemparticipatesintheanalgesiceffectofflunixinmeglumineintherat AT trailovicsasa largininenosystemparticipatesintheanalgesiceffectofflunixinmeglumineintherat AT jovanovicmilan largininenosystemparticipatesintheanalgesiceffectofflunixinmeglumineintherat
_version_	1718425338026917888

L-Arginine-No System Participates in the Analgesic Effect of Flunixin Meglumine in the Rat

Ejemplares similares