Effects of adding tripterygium glycosides to angiotensin-converting enzyme inhibitors or angiotensin receptor blockers on albuminuria in patients with diabetic nephropathy

Introduction: Tripterygium glycosides (TGs) have been widely used in China to treat diabetic nephropathy (DN); however, proof of their use is scarce. The present study aimed to evaluate the effectiveness and safety of adding TGs to angiotensin-converting enzyme (ACE) inhibitors or angiotensin recept...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jin-Ying Fang, Yue Yang, Zheng Zhang, Shi-Min Jiang, Tian-Yu Yu, Wen-Ge Li
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2020
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/18e853934dea4bfaaee54b50b73a26ee
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:18e853934dea4bfaaee54b50b73a26ee
record_format	dspace
spelling	oai:doaj.org-article:18e853934dea4bfaaee54b50b73a26ee2021-12-02T16:02:14ZEffects of adding tripterygium glycosides to angiotensin-converting enzyme inhibitors or angiotensin receptor blockers on albuminuria in patients with diabetic nephropathy2095-882X10.1016/j.cdtm.2019.12.008https://doaj.org/article/18e853934dea4bfaaee54b50b73a26ee2020-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X19300945https://doaj.org/toc/2095-882XIntroduction: Tripterygium glycosides (TGs) have been widely used in China to treat diabetic nephropathy (DN); however, proof of their use is scarce. The present study aimed to evaluate the effectiveness and safety of adding TGs to angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs). Methods: By searching Embase, MEDLINE, Cochrane Library, SINOMED, China National Knowledge Infrastructure, VIP Information/Chinese Scientific Journals, and WANFANG databases, we identified previous studies that met the specific selection criteria and included them in the meta-analysis. Analyses were performed using Review Manager (version 5.3). Results: Nine randomized controlled trials were included in the final meta-analysis. Patients were compared before and after treatment with ACE inhibitors or ARBs plus TGs, or ACE inhibitors or ARBs alone. The results revealed that treatment with ACE inhibitors or ARBs plus TGs resulted in significantly greater reductions in 24-h urinary total protein (UTP) levels (trial duration <2 months, mean difference [MD]: −0.25; 95% confidence interval [CI]: −0.32, −0.18; trial duration between 2 and 6 months, MD: −0.39; 95% CI: −0.44, −0.33; trial duration >6 months, MD: −2.09; 95% CI: −2.89, −1.29) compared with treatment using ACE inhibitors or ARBs alone. Additionally, ACE inhibitors or ARBs plus TGs showed better results after long-term administration. Treatment with ACE inhibitors or ARBs plus TGs resulted in significantly greater reductions in serum creatinine (SCr) compared with ACE inhibitors or ARBs alone (MD: −9.87; 95% CI: −13.76, −5.97). Conclusion: In patients with DN, adding TGs to ACE inhibitors or ARBs significantly lowered both the 24-h UTP and SCr levels. Therefore, ACE inhibitors or ARBs plus TGs might improve the treatment of DN in patients. Keywords: Tripterygium glycosides, Diabetic nephropathy, Angiotensin-converting enzyme inhibitor, Angiotensin receptor blockers, Meta-analysisJin-Ying FangYue YangZheng ZhangShi-Min JiangTian-Yu YuWen-Ge LiKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 6, Iss 1, Pp 18-26 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Jin-Ying Fang Yue Yang Zheng Zhang Shi-Min Jiang Tian-Yu Yu Wen-Ge Li Effects of adding tripterygium glycosides to angiotensin-converting enzyme inhibitors or angiotensin receptor blockers on albuminuria in patients with diabetic nephropathy
description	Introduction: Tripterygium glycosides (TGs) have been widely used in China to treat diabetic nephropathy (DN); however, proof of their use is scarce. The present study aimed to evaluate the effectiveness and safety of adding TGs to angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs). Methods: By searching Embase, MEDLINE, Cochrane Library, SINOMED, China National Knowledge Infrastructure, VIP Information/Chinese Scientific Journals, and WANFANG databases, we identified previous studies that met the specific selection criteria and included them in the meta-analysis. Analyses were performed using Review Manager (version 5.3). Results: Nine randomized controlled trials were included in the final meta-analysis. Patients were compared before and after treatment with ACE inhibitors or ARBs plus TGs, or ACE inhibitors or ARBs alone. The results revealed that treatment with ACE inhibitors or ARBs plus TGs resulted in significantly greater reductions in 24-h urinary total protein (UTP) levels (trial duration <2 months, mean difference [MD]: −0.25; 95% confidence interval [CI]: −0.32, −0.18; trial duration between 2 and 6 months, MD: −0.39; 95% CI: −0.44, −0.33; trial duration >6 months, MD: −2.09; 95% CI: −2.89, −1.29) compared with treatment using ACE inhibitors or ARBs alone. Additionally, ACE inhibitors or ARBs plus TGs showed better results after long-term administration. Treatment with ACE inhibitors or ARBs plus TGs resulted in significantly greater reductions in serum creatinine (SCr) compared with ACE inhibitors or ARBs alone (MD: −9.87; 95% CI: −13.76, −5.97). Conclusion: In patients with DN, adding TGs to ACE inhibitors or ARBs significantly lowered both the 24-h UTP and SCr levels. Therefore, ACE inhibitors or ARBs plus TGs might improve the treatment of DN in patients. Keywords: Tripterygium glycosides, Diabetic nephropathy, Angiotensin-converting enzyme inhibitor, Angiotensin receptor blockers, Meta-analysis
format	article
author	Jin-Ying Fang Yue Yang Zheng Zhang Shi-Min Jiang Tian-Yu Yu Wen-Ge Li
author_facet	Jin-Ying Fang Yue Yang Zheng Zhang Shi-Min Jiang Tian-Yu Yu Wen-Ge Li
author_sort	Jin-Ying Fang
title	Effects of adding tripterygium glycosides to angiotensin-converting enzyme inhibitors or angiotensin receptor blockers on albuminuria in patients with diabetic nephropathy
title_short	Effects of adding tripterygium glycosides to angiotensin-converting enzyme inhibitors or angiotensin receptor blockers on albuminuria in patients with diabetic nephropathy
title_full	Effects of adding tripterygium glycosides to angiotensin-converting enzyme inhibitors or angiotensin receptor blockers on albuminuria in patients with diabetic nephropathy
title_fullStr	Effects of adding tripterygium glycosides to angiotensin-converting enzyme inhibitors or angiotensin receptor blockers on albuminuria in patients with diabetic nephropathy
title_full_unstemmed	Effects of adding tripterygium glycosides to angiotensin-converting enzyme inhibitors or angiotensin receptor blockers on albuminuria in patients with diabetic nephropathy
title_sort	effects of adding tripterygium glycosides to angiotensin-converting enzyme inhibitors or angiotensin receptor blockers on albuminuria in patients with diabetic nephropathy
publisher	KeAi Communications Co., Ltd.
publishDate	2020
url	https://doaj.org/article/18e853934dea4bfaaee54b50b73a26ee
work_keys_str_mv	AT jinyingfang effectsofaddingtripterygiumglycosidestoangiotensinconvertingenzymeinhibitorsorangiotensinreceptorblockersonalbuminuriainpatientswithdiabeticnephropathy AT yueyang effectsofaddingtripterygiumglycosidestoangiotensinconvertingenzymeinhibitorsorangiotensinreceptorblockersonalbuminuriainpatientswithdiabeticnephropathy AT zhengzhang effectsofaddingtripterygiumglycosidestoangiotensinconvertingenzymeinhibitorsorangiotensinreceptorblockersonalbuminuriainpatientswithdiabeticnephropathy AT shiminjiang effectsofaddingtripterygiumglycosidestoangiotensinconvertingenzymeinhibitorsorangiotensinreceptorblockersonalbuminuriainpatientswithdiabeticnephropathy AT tianyuyu effectsofaddingtripterygiumglycosidestoangiotensinconvertingenzymeinhibitorsorangiotensinreceptorblockersonalbuminuriainpatientswithdiabeticnephropathy AT wengeli effectsofaddingtripterygiumglycosidestoangiotensinconvertingenzymeinhibitorsorangiotensinreceptorblockersonalbuminuriainpatientswithdiabeticnephropathy
_version_	1718385256113897472

Effects of adding tripterygium glycosides to angiotensin-converting enzyme inhibitors or angiotensin receptor blockers on albuminuria in patients with diabetic nephropathy

Ejemplares similares