Is the Chronic Kidney Disease Epidemiology Collaboration creatinine–cystatin C equation useful for glomerular filtration rate estimation in the elderly?
Xun Liu,1,2,* Huijuan Ma,1,* Hui Huang,3 Cheng Wang,1 Hua Tang,1 Ming Li,1 Yanni Wang,1 Tanqi Lou1 1Division of Nephrology, Department of Internal Medicine, The Third Affiliated Hospital of Sun Yat-sen University, 2College of Biology Engineering, South China University of Technology, 3Department of...
Guardado en:
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2013
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/18e85e12b2454476a830426f4bb4328f |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:18e85e12b2454476a830426f4bb4328f |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:18e85e12b2454476a830426f4bb4328f2021-12-02T00:33:44ZIs the Chronic Kidney Disease Epidemiology Collaboration creatinine–cystatin C equation useful for glomerular filtration rate estimation in the elderly?1178-1998https://doaj.org/article/18e85e12b2454476a830426f4bb4328f2013-10-01T00:00:00Zhttps://www.dovepress.com/is-the-chronic-kidney-disease-epidemiology-collaboration-creatininenda-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Xun Liu,1,2,* Huijuan Ma,1,* Hui Huang,3 Cheng Wang,1 Hua Tang,1 Ming Li,1 Yanni Wang,1 Tanqi Lou1 1Division of Nephrology, Department of Internal Medicine, The Third Affiliated Hospital of Sun Yat-sen University, 2College of Biology Engineering, South China University of Technology, 3Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China*These authors contributed equally to the paperBackground: We aimed to evaluate the performance of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine–cystatin C equation in a cohort of elderly Chinese participants.Materials and methods: Glomerular filtration rate (GFR) was measured in 431 elderly Chinese participants by the technetium-99m diethylene-triamine-penta-acetic acid (99mTc-DTPA) renal dynamic imaging method, and was calibrated equally to the dual plasma sample 99mTc-DTPA-GFR. Performance of the CKD-EPI creatinine–cystatin C equation was compared with the Cockroft–Gault equation, the re-expressed 4-variable Modification of Diet in Renal Disease (MDRD) equation, and the CKD-EPI creatinine equation.Results: Although the bias of the CKD-EPI creatinine–cystatin C equation was greater than with the other equations (median difference, 5.7 mL/minute/1.73 m2 versus a range from 0.4–2.5 mL/minute/1.73 m2; P<0.001 for all), the precision was improved with the CKD-EPI creatinine–cystatin C equation (interquartile range for the difference, 19.5 mL/minute/1.73 m2 versus a range from 23.0–23.6 mL/minute/1.73 m2; P<0.001 for all comparisons), leading to slight improvement in accuracy (median absolute difference, 10.5 mL/minute/1.73 m2 versus 12.2 and 11.4 mL/minute/1.73 m2 for the Cockcroft–Gault equation and the re-expressed 4-variable MDRD equation, P=0.04 for both; 11.6 mL/minute/1.73 m2 for the CKD-EPI creatinine equation, P=0.11), as the optimal scores of performance (6.0 versus a range from 1.0–2.0 for the other equations). Higher GFR category and diabetes were independent factors that negatively correlated with the accuracy of the CKD-EPI creatinine–cystatin C equation (β =-0.184 and -0.113, P<0.001 and P=0.02, respectively).Conclusion: Compared with the creatinine-based equations, the CKD-EPI creatinine–cystatin C equation is more suitable for the elderly Chinese population. However, the cost-effectiveness of the CKD-EPI creatinine–cystatin C equation for clinical use should be considered.Keywords: elderly, equation, glomerular filtration rate, serum creatinine, cystatin CLiu XMa HHuang HWang CTang HLi MWang YLou TDove Medical Pressarticleelderlyequationglomerular filtration rateserum creatininecystatin CGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 8, Pp 1387-1391 (2013) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
elderly equation glomerular filtration rate serum creatinine cystatin C Geriatrics RC952-954.6 |
| spellingShingle |
elderly equation glomerular filtration rate serum creatinine cystatin C Geriatrics RC952-954.6 Liu X Ma H Huang H Wang C Tang H Li M Wang Y Lou T Is the Chronic Kidney Disease Epidemiology Collaboration creatinine–cystatin C equation useful for glomerular filtration rate estimation in the elderly? |
| description |
Xun Liu,1,2,* Huijuan Ma,1,* Hui Huang,3 Cheng Wang,1 Hua Tang,1 Ming Li,1 Yanni Wang,1 Tanqi Lou1 1Division of Nephrology, Department of Internal Medicine, The Third Affiliated Hospital of Sun Yat-sen University, 2College of Biology Engineering, South China University of Technology, 3Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China*These authors contributed equally to the paperBackground: We aimed to evaluate the performance of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine–cystatin C equation in a cohort of elderly Chinese participants.Materials and methods: Glomerular filtration rate (GFR) was measured in 431 elderly Chinese participants by the technetium-99m diethylene-triamine-penta-acetic acid (99mTc-DTPA) renal dynamic imaging method, and was calibrated equally to the dual plasma sample 99mTc-DTPA-GFR. Performance of the CKD-EPI creatinine–cystatin C equation was compared with the Cockroft–Gault equation, the re-expressed 4-variable Modification of Diet in Renal Disease (MDRD) equation, and the CKD-EPI creatinine equation.Results: Although the bias of the CKD-EPI creatinine–cystatin C equation was greater than with the other equations (median difference, 5.7 mL/minute/1.73 m2 versus a range from 0.4–2.5 mL/minute/1.73 m2; P<0.001 for all), the precision was improved with the CKD-EPI creatinine–cystatin C equation (interquartile range for the difference, 19.5 mL/minute/1.73 m2 versus a range from 23.0–23.6 mL/minute/1.73 m2; P<0.001 for all comparisons), leading to slight improvement in accuracy (median absolute difference, 10.5 mL/minute/1.73 m2 versus 12.2 and 11.4 mL/minute/1.73 m2 for the Cockcroft–Gault equation and the re-expressed 4-variable MDRD equation, P=0.04 for both; 11.6 mL/minute/1.73 m2 for the CKD-EPI creatinine equation, P=0.11), as the optimal scores of performance (6.0 versus a range from 1.0–2.0 for the other equations). Higher GFR category and diabetes were independent factors that negatively correlated with the accuracy of the CKD-EPI creatinine–cystatin C equation (β =-0.184 and -0.113, P<0.001 and P=0.02, respectively).Conclusion: Compared with the creatinine-based equations, the CKD-EPI creatinine–cystatin C equation is more suitable for the elderly Chinese population. However, the cost-effectiveness of the CKD-EPI creatinine–cystatin C equation for clinical use should be considered.Keywords: elderly, equation, glomerular filtration rate, serum creatinine, cystatin C |
| format |
article |
| author |
Liu X Ma H Huang H Wang C Tang H Li M Wang Y Lou T |
| author_facet |
Liu X Ma H Huang H Wang C Tang H Li M Wang Y Lou T |
| author_sort |
Liu X |
| title |
Is the Chronic Kidney Disease Epidemiology Collaboration creatinine–cystatin C equation useful for glomerular filtration rate estimation in the elderly? |
| title_short |
Is the Chronic Kidney Disease Epidemiology Collaboration creatinine–cystatin C equation useful for glomerular filtration rate estimation in the elderly? |
| title_full |
Is the Chronic Kidney Disease Epidemiology Collaboration creatinine–cystatin C equation useful for glomerular filtration rate estimation in the elderly? |
| title_fullStr |
Is the Chronic Kidney Disease Epidemiology Collaboration creatinine–cystatin C equation useful for glomerular filtration rate estimation in the elderly? |
| title_full_unstemmed |
Is the Chronic Kidney Disease Epidemiology Collaboration creatinine–cystatin C equation useful for glomerular filtration rate estimation in the elderly? |
| title_sort |
is the chronic kidney disease epidemiology collaboration creatinine–cystatin c equation useful for glomerular filtration rate estimation in the elderly? |
| publisher |
Dove Medical Press |
| publishDate |
2013 |
| url |
https://doaj.org/article/18e85e12b2454476a830426f4bb4328f |
| work_keys_str_mv |
AT liux isthechronickidneydiseaseepidemiologycollaborationcreatininendashcystatincequationusefulforglomerularfiltrationrateestimationintheelderly AT mah isthechronickidneydiseaseepidemiologycollaborationcreatininendashcystatincequationusefulforglomerularfiltrationrateestimationintheelderly AT huangh isthechronickidneydiseaseepidemiologycollaborationcreatininendashcystatincequationusefulforglomerularfiltrationrateestimationintheelderly AT wangc isthechronickidneydiseaseepidemiologycollaborationcreatininendashcystatincequationusefulforglomerularfiltrationrateestimationintheelderly AT tangh isthechronickidneydiseaseepidemiologycollaborationcreatininendashcystatincequationusefulforglomerularfiltrationrateestimationintheelderly AT lim isthechronickidneydiseaseepidemiologycollaborationcreatininendashcystatincequationusefulforglomerularfiltrationrateestimationintheelderly AT wangy isthechronickidneydiseaseepidemiologycollaborationcreatininendashcystatincequationusefulforglomerularfiltrationrateestimationintheelderly AT lout isthechronickidneydiseaseepidemiologycollaborationcreatininendashcystatincequationusefulforglomerularfiltrationrateestimationintheelderly |
| _version_ |
1718403600019881984 |