Tenacious Researchers Identify a Weakness in All Ebolaviruses

ABSTRACT The Ebolavirus genus has at least five members, four of which are known to cause deadly disease in humans. An ideal therapy or a vaccine would protect against all ebolaviruses, but identifying a common weakness in all of them has remained elusive. West et al. [B. R. West, C. L. Moyer, L. B....

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Autor principal:	Rebecca M. DuBois
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2018
Materias:	ebola virus neutralizing antibodies protein structure-function Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/18e9280b38cb4bcbb79e675b54c364ea
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spelling	oai:doaj.org-article:18e9280b38cb4bcbb79e675b54c364ea2021-11-15T15:52:20ZTenacious Researchers Identify a Weakness in All Ebolaviruses10.1128/mBio.02249-182150-7511https://doaj.org/article/18e9280b38cb4bcbb79e675b54c364ea2018-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02249-18https://doaj.org/toc/2150-7511ABSTRACT The Ebolavirus genus has at least five members, four of which are known to cause deadly disease in humans. An ideal therapy or a vaccine would protect against all ebolaviruses, but identifying a common weakness in all of them has remained elusive. West et al. [B. R. West, C. L. Moyer, L. B. King, M. L. Fusco, et al., mBio 9(5):e01674-18, 2018, https://doi.org/10.1128/mBio.01674-18] make the exciting discovery of an “Achilles’ heel,” a cryptic and conserved pocket, on the surface antigen glycoprotein (GP) that is nearly identical in all known ebolaviruses. Key to this discovery was their study of antibody ADI-15878, the only isolated human antibody that can block infectivity of all known ebolaviruses. Following tenacious efforts in X-ray crystallography, West et al. report the high-resolution crystal structures of the Ebola virus GP and the Bundibugyo virus GP, each bound to antibody ADI-15878. These structures reveal a highly conserved but partially obscured site on the virus GP, providing a foundation for design of vaccine antigens or antiviral therapies.Rebecca M. DuBoisAmerican Society for Microbiologyarticleebola virusneutralizing antibodiesprotein structure-functionMicrobiologyQR1-502ENmBio, Vol 9, Iss 6 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	ebola virus neutralizing antibodies protein structure-function Microbiology QR1-502
spellingShingle	ebola virus neutralizing antibodies protein structure-function Microbiology QR1-502 Rebecca M. DuBois Tenacious Researchers Identify a Weakness in All Ebolaviruses
description	ABSTRACT The Ebolavirus genus has at least five members, four of which are known to cause deadly disease in humans. An ideal therapy or a vaccine would protect against all ebolaviruses, but identifying a common weakness in all of them has remained elusive. West et al. [B. R. West, C. L. Moyer, L. B. King, M. L. Fusco, et al., mBio 9(5):e01674-18, 2018, https://doi.org/10.1128/mBio.01674-18] make the exciting discovery of an “Achilles’ heel,” a cryptic and conserved pocket, on the surface antigen glycoprotein (GP) that is nearly identical in all known ebolaviruses. Key to this discovery was their study of antibody ADI-15878, the only isolated human antibody that can block infectivity of all known ebolaviruses. Following tenacious efforts in X-ray crystallography, West et al. report the high-resolution crystal structures of the Ebola virus GP and the Bundibugyo virus GP, each bound to antibody ADI-15878. These structures reveal a highly conserved but partially obscured site on the virus GP, providing a foundation for design of vaccine antigens or antiviral therapies.
format	article
author	Rebecca M. DuBois
author_facet	Rebecca M. DuBois
author_sort	Rebecca M. DuBois
title	Tenacious Researchers Identify a Weakness in All Ebolaviruses
title_short	Tenacious Researchers Identify a Weakness in All Ebolaviruses
title_full	Tenacious Researchers Identify a Weakness in All Ebolaviruses
title_fullStr	Tenacious Researchers Identify a Weakness in All Ebolaviruses
title_full_unstemmed	Tenacious Researchers Identify a Weakness in All Ebolaviruses
title_sort	tenacious researchers identify a weakness in all ebolaviruses
publisher	American Society for Microbiology
publishDate	2018
url	https://doaj.org/article/18e9280b38cb4bcbb79e675b54c364ea
work_keys_str_mv	AT rebeccamdubois tenaciousresearchersidentifyaweaknessinallebolaviruses
_version_	1718427257902465024

Tenacious Researchers Identify a Weakness in All Ebolaviruses

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