Angiotensin II type 1a receptor loss ameliorates chronic tubulointerstitial damage after renal ischemia reperfusion

Angiotensin II type 1a receptor loss ameliorates chronic tubulointerstitial damage after renal ischemia reperfusion

Abstract We investigate whether suppressing the activation of the angiotensin II type 1a receptor (AT1a) can ameliorate severe chronic tubulointerstitial damage (TID) after renal ischemia reperfusion (IR) using AT1a knockout homozygous (AT1a−/−) male mice. To induce severe chronic TID after renal IR...

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Main Authors: Yoko Fujita, Daisuke Ichikawa, Takeshi Sugaya, Keiichi Ohata, Jun Tanabe, Kazuho Inoue, Seiko Hoshino, Tatsuru Togo, Minoru Watanabe, Kenjiro Kimura, Yugo Shibagaki, Atsuko Kamijo-Ikemori
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/18eb73f97dd64954b6068a75ce099b1d
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https://doaj.org/article/18eb73f97dd64954b6068a75ce099b1d

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