Association of genetic variants with self-assessed color categories in Brazilians.

The Brazilian population was formed by extensive admixture of three different ancestral roots: Amerindians, Europeans and Africans. Our previous work has shown that at an individual level, ancestry, as estimated using molecular markers, was a poor predictor of color in Brazilians. We now investigate...

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Autores principales:	Danielle Fernandes Durso, Sergio Paulo Bydlowski, Mara Helena Hutz, Guilherme Suarez-Kurtz, Tiago R Magalhães, Sérgio Danilo Junho Pena
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/18ebd9ef67a742138bee077948496efc
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spelling	oai:doaj.org-article:18ebd9ef67a742138bee077948496efc2021-11-18T08:38:38ZAssociation of genetic variants with self-assessed color categories in Brazilians.1932-620310.1371/journal.pone.0083926https://doaj.org/article/18ebd9ef67a742138bee077948496efc2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24416183/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The Brazilian population was formed by extensive admixture of three different ancestral roots: Amerindians, Europeans and Africans. Our previous work has shown that at an individual level, ancestry, as estimated using molecular markers, was a poor predictor of color in Brazilians. We now investigate if SNPs known to be associated with human skin pigmentation can be used to predict color in Brazilians. For that, we studied the association of fifteen SNPs, previously known to be linked with skin color, in 243 unrelated Brazilian individuals self-identified as White, Browns or Blacks from Rio de Janeiro and 212 unrelated Brazilian individuals self-identified as White or Blacks from São Paulo. The significance of association of SNP genotypes with self-assessed color was evaluated using partial regression analysis. After controlling for ancestry estimates as covariates, only four SNPs remained significantly associated with skin pigmentation: rs1426654 and rs2555364 within SLC24A5, rs16891982 at SLC45A2 and rs1042602 at TYR. These loci are known to be involved in melanin synthesis or transport of melanosomes. We found that neither genotypes of these SNPs, nor their combination with biogeographical ancestry in principal component analysis, could predict self-assessed color in Brazilians at an individual level. However, significant correlations did emerge at group level, demonstrating that even though elements other than skin, eye and hair pigmentation do influence self-assessed color in Brazilians, the sociological act of self-classification is still substantially dependent of genotype at these four SNPs.Danielle Fernandes DursoSergio Paulo BydlowskiMara Helena HutzGuilherme Suarez-KurtzTiago R MagalhãesSérgio Danilo Junho PenaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e83926 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Danielle Fernandes Durso Sergio Paulo Bydlowski Mara Helena Hutz Guilherme Suarez-Kurtz Tiago R Magalhães Sérgio Danilo Junho Pena Association of genetic variants with self-assessed color categories in Brazilians.
description	The Brazilian population was formed by extensive admixture of three different ancestral roots: Amerindians, Europeans and Africans. Our previous work has shown that at an individual level, ancestry, as estimated using molecular markers, was a poor predictor of color in Brazilians. We now investigate if SNPs known to be associated with human skin pigmentation can be used to predict color in Brazilians. For that, we studied the association of fifteen SNPs, previously known to be linked with skin color, in 243 unrelated Brazilian individuals self-identified as White, Browns or Blacks from Rio de Janeiro and 212 unrelated Brazilian individuals self-identified as White or Blacks from São Paulo. The significance of association of SNP genotypes with self-assessed color was evaluated using partial regression analysis. After controlling for ancestry estimates as covariates, only four SNPs remained significantly associated with skin pigmentation: rs1426654 and rs2555364 within SLC24A5, rs16891982 at SLC45A2 and rs1042602 at TYR. These loci are known to be involved in melanin synthesis or transport of melanosomes. We found that neither genotypes of these SNPs, nor their combination with biogeographical ancestry in principal component analysis, could predict self-assessed color in Brazilians at an individual level. However, significant correlations did emerge at group level, demonstrating that even though elements other than skin, eye and hair pigmentation do influence self-assessed color in Brazilians, the sociological act of self-classification is still substantially dependent of genotype at these four SNPs.
format	article
author	Danielle Fernandes Durso Sergio Paulo Bydlowski Mara Helena Hutz Guilherme Suarez-Kurtz Tiago R Magalhães Sérgio Danilo Junho Pena
author_facet	Danielle Fernandes Durso Sergio Paulo Bydlowski Mara Helena Hutz Guilherme Suarez-Kurtz Tiago R Magalhães Sérgio Danilo Junho Pena
author_sort	Danielle Fernandes Durso
title	Association of genetic variants with self-assessed color categories in Brazilians.
title_short	Association of genetic variants with self-assessed color categories in Brazilians.
title_full	Association of genetic variants with self-assessed color categories in Brazilians.
title_fullStr	Association of genetic variants with self-assessed color categories in Brazilians.
title_full_unstemmed	Association of genetic variants with self-assessed color categories in Brazilians.
title_sort	association of genetic variants with self-assessed color categories in brazilians.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/18ebd9ef67a742138bee077948496efc
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Association of genetic variants with self-assessed color categories in Brazilians.

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