Signal Transduction of Mineralocorticoid and Angiotensin II Receptors in the Central Control of Sodium Appetite: A Narrative Review

Sodium appetite is an innate behavior occurring in response to sodium depletion that induces homeostatic responses such as the secretion of the mineralocorticoid hormone aldosterone from the zona glomerulosa of the adrenal cortex and the stimulation of the peptide hormone angiotensin II (ANG II). Th...

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Autores principales:	Michele Iovino, Tullio Messana, Giuseppe Lisco, Aldo Vanacore, Vito Angelo Giagulli, Edoardo Guastamacchia, Giovanni De Pergola, Vincenzo Triggiani
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	sodium appetite aldosterone angiotensin II organum vasculosum lamina terminalis paraventricular nucleus oxytocin Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/18ed44ed865847aba917ce24b5a3d3e0
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spelling	oai:doaj.org-article:18ed44ed865847aba917ce24b5a3d3e02021-11-11T17:11:31ZSignal Transduction of Mineralocorticoid and Angiotensin II Receptors in the Central Control of Sodium Appetite: A Narrative Review10.3390/ijms2221117351422-00671661-6596https://doaj.org/article/18ed44ed865847aba917ce24b5a3d3e02021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11735https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Sodium appetite is an innate behavior occurring in response to sodium depletion that induces homeostatic responses such as the secretion of the mineralocorticoid hormone aldosterone from the zona glomerulosa of the adrenal cortex and the stimulation of the peptide hormone angiotensin II (ANG II). The synergistic action of these hormones signals to the brain the sodium appetite that represents the increased palatability for salt intake. This narrative review summarizes the main data dealing with the role of mineralocorticoid and ANG II receptors in the central control of sodium appetite. Appropriate keywords and MeSH terms were identified and searched in PubMed. References to original articles and reviews were examined, selected, and discussed. Several brain areas control sodium appetite, including the nucleus of the solitary tract, which contains aldosterone-sensitive HSD2 neurons, and the organum vasculosum lamina terminalis (OVLT) that contains ANG II-sensitive neurons. Furthermore, sodium appetite is under the control of signaling proteins such as mitogen-activated protein kinase (MAPK) and inositol 1,4,5-thriphosphate (IP3). ANG II stimulates salt intake via MAPK, while combined ANG II and aldosterone action induce sodium intake via the IP3 signaling pathway. Finally, aldosterone and ANG II stimulate OVLT neurons and suppress oxytocin secretion inhibiting the neuronal activity of the paraventricular nucleus, thus disinhibiting the OVLT activity to aldosterone and ANG II stimulation.Michele IovinoTullio MessanaGiuseppe LiscoAldo VanacoreVito Angelo GiagulliEdoardo GuastamacchiaGiovanni De PergolaVincenzo TriggianiMDPI AGarticlesodium appetitealdosteroneangiotensin IIorganum vasculosum lamina terminalisparaventricular nucleusoxytocinBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11735, p 11735 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sodium appetite aldosterone angiotensin II organum vasculosum lamina terminalis paraventricular nucleus oxytocin Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	sodium appetite aldosterone angiotensin II organum vasculosum lamina terminalis paraventricular nucleus oxytocin Biology (General) QH301-705.5 Chemistry QD1-999 Michele Iovino Tullio Messana Giuseppe Lisco Aldo Vanacore Vito Angelo Giagulli Edoardo Guastamacchia Giovanni De Pergola Vincenzo Triggiani Signal Transduction of Mineralocorticoid and Angiotensin II Receptors in the Central Control of Sodium Appetite: A Narrative Review
description	Sodium appetite is an innate behavior occurring in response to sodium depletion that induces homeostatic responses such as the secretion of the mineralocorticoid hormone aldosterone from the zona glomerulosa of the adrenal cortex and the stimulation of the peptide hormone angiotensin II (ANG II). The synergistic action of these hormones signals to the brain the sodium appetite that represents the increased palatability for salt intake. This narrative review summarizes the main data dealing with the role of mineralocorticoid and ANG II receptors in the central control of sodium appetite. Appropriate keywords and MeSH terms were identified and searched in PubMed. References to original articles and reviews were examined, selected, and discussed. Several brain areas control sodium appetite, including the nucleus of the solitary tract, which contains aldosterone-sensitive HSD2 neurons, and the organum vasculosum lamina terminalis (OVLT) that contains ANG II-sensitive neurons. Furthermore, sodium appetite is under the control of signaling proteins such as mitogen-activated protein kinase (MAPK) and inositol 1,4,5-thriphosphate (IP3). ANG II stimulates salt intake via MAPK, while combined ANG II and aldosterone action induce sodium intake via the IP3 signaling pathway. Finally, aldosterone and ANG II stimulate OVLT neurons and suppress oxytocin secretion inhibiting the neuronal activity of the paraventricular nucleus, thus disinhibiting the OVLT activity to aldosterone and ANG II stimulation.
format	article
author	Michele Iovino Tullio Messana Giuseppe Lisco Aldo Vanacore Vito Angelo Giagulli Edoardo Guastamacchia Giovanni De Pergola Vincenzo Triggiani
author_facet	Michele Iovino Tullio Messana Giuseppe Lisco Aldo Vanacore Vito Angelo Giagulli Edoardo Guastamacchia Giovanni De Pergola Vincenzo Triggiani
author_sort	Michele Iovino
title	Signal Transduction of Mineralocorticoid and Angiotensin II Receptors in the Central Control of Sodium Appetite: A Narrative Review
title_short	Signal Transduction of Mineralocorticoid and Angiotensin II Receptors in the Central Control of Sodium Appetite: A Narrative Review
title_full	Signal Transduction of Mineralocorticoid and Angiotensin II Receptors in the Central Control of Sodium Appetite: A Narrative Review
title_fullStr	Signal Transduction of Mineralocorticoid and Angiotensin II Receptors in the Central Control of Sodium Appetite: A Narrative Review
title_full_unstemmed	Signal Transduction of Mineralocorticoid and Angiotensin II Receptors in the Central Control of Sodium Appetite: A Narrative Review
title_sort	signal transduction of mineralocorticoid and angiotensin ii receptors in the central control of sodium appetite: a narrative review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/18ed44ed865847aba917ce24b5a3d3e0
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Signal Transduction of Mineralocorticoid and Angiotensin II Receptors in the Central Control of Sodium Appetite: A Narrative Review

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