Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling

Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling

Caspase-2 is constitutively expressed in neurons yet its physiological function is not known. Here, the authors report a role for Caspase-2 activity in synaptic plasticity via a reduction in dendritic spine density through cleavage of Rictor suggesting a mechanism to explain the impairments in cogni...

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Autores principales: Zhi-Xiang Xu, Ji-Wei Tan, Haifei Xu, Cassandra J. Hill, Olga Ostrovskaya, Kirill A. Martemyanov, Baoji Xu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/18f0a7d21924425ea758ad604fe5ea8d
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spelling oai:doaj.org-article:18f0a7d21924425ea758ad604fe5ea8d2021-12-02T16:58:17ZCaspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling10.1038/s41467-019-11575-12041-1723https://doaj.org/article/18f0a7d21924425ea758ad604fe5ea8d2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11575-1https://doaj.org/toc/2041-1723Caspase-2 is constitutively expressed in neurons yet its physiological function is not known. Here, the authors report a role for Caspase-2 activity in synaptic plasticity via a reduction in dendritic spine density through cleavage of Rictor suggesting a mechanism to explain the impairments in cognitive flexibility observed in Caspase-2 knockout mice.Zhi-Xiang XuJi-Wei TanHaifei XuCassandra J. HillOlga OstrovskayaKirill A. MartemyanovBaoji XuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Zhi-Xiang Xu
Ji-Wei Tan
Haifei Xu
Cassandra J. Hill
Olga Ostrovskaya
Kirill A. Martemyanov
Baoji Xu
Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling
description Caspase-2 is constitutively expressed in neurons yet its physiological function is not known. Here, the authors report a role for Caspase-2 activity in synaptic plasticity via a reduction in dendritic spine density through cleavage of Rictor suggesting a mechanism to explain the impairments in cognitive flexibility observed in Caspase-2 knockout mice.
format article
author Zhi-Xiang Xu
Ji-Wei Tan
Haifei Xu
Cassandra J. Hill
Olga Ostrovskaya
Kirill A. Martemyanov
Baoji Xu
author_facet Zhi-Xiang Xu
Ji-Wei Tan
Haifei Xu
Cassandra J. Hill
Olga Ostrovskaya
Kirill A. Martemyanov
Baoji Xu
author_sort Zhi-Xiang Xu
title Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling
title_short Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling
title_full Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling
title_fullStr Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling
title_full_unstemmed Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling
title_sort caspase-2 promotes ampa receptor internalization and cognitive flexibility via mtorc2-akt-gsk3β signaling
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/18f0a7d21924425ea758ad604fe5ea8d
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