Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling

Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling

Caspase-2 is constitutively expressed in neurons yet its physiological function is not known. Here, the authors report a role for Caspase-2 activity in synaptic plasticity via a reduction in dendritic spine density through cleavage of Rictor suggesting a mechanism to explain the impairments in cogni...

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Autores principales: Zhi-Xiang Xu, Ji-Wei Tan, Haifei Xu, Cassandra J. Hill, Olga Ostrovskaya, Kirill A. Martemyanov, Baoji Xu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/18f0a7d21924425ea758ad604fe5ea8d
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