Serotonergic dysfunctions and abnormal iron metabolism: Relevant to mental fatigue of Parkinson disease
Abstract Fatigue is a very common non-motor symptom in Parkinson disease (PD) patients. It included physical fatigue and mental fatigue. The potential mechanisms of mental fatigue involving serotonergic dysfunction and abnormal iron metabolism are still unknown. Therefore, we evaluated the fatigue s...
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2016
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oai:doaj.org-article:18f144a2c18a4488a18ddb67fe445f752021-12-02T15:06:06ZSerotonergic dysfunctions and abnormal iron metabolism: Relevant to mental fatigue of Parkinson disease10.1038/s41598-016-0018-z2045-2322https://doaj.org/article/18f144a2c18a4488a18ddb67fe445f752016-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-016-0018-zhttps://doaj.org/toc/2045-2322Abstract Fatigue is a very common non-motor symptom in Parkinson disease (PD) patients. It included physical fatigue and mental fatigue. The potential mechanisms of mental fatigue involving serotonergic dysfunction and abnormal iron metabolism are still unknown. Therefore, we evaluated the fatigue symptoms, classified PD patients into fatigue group and non-fatigue group, and detected the levels of serotonin, iron and related proteins in CSF and serum. In CSF, 5-HT level is significantly decreased and the levels of iron and transferrin are dramatically increased in fatigue group. In fatigue group, mental fatigue score is negatively correlated with 5-HT level in CSF, and positively correlated with the scores of depression and excessive daytime sleepiness, and disease duration, also, mental fatigue is positively correlated with the levels of iron and transferrin in CSF. Transferrin level is negatively correlated with 5-HT level in CSF. In serum, the levels of 5-HT and transferrin are markedly decreased in fatigue group; mental fatigue score exhibits a negative correlation with 5-HT level. Thus serotonin dysfunction in both central and peripheral systems may be correlated with mental fatigue through abnormal iron metabolism. Depression, excessive daytime sleepiness and disease duration were the risk factors for mental fatigue of PD.Li-Jun ZuoShu-Yang YuYang HuFang WangYing-Shan PiaoTeng-Hong LianQiu-Jin YuRui-Dan WangLi-Xia LiPeng GuoYang DuRong-Yan ZhuZhao JinYa-Jie WangXiao-Min WangPiu ChanSheng-Di ChenYong-Jun WangWei ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 6, Iss 1, Pp 1-9 (2016) |
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Medicine R Science Q Li-Jun Zuo Shu-Yang Yu Yang Hu Fang Wang Ying-Shan Piao Teng-Hong Lian Qiu-Jin Yu Rui-Dan Wang Li-Xia Li Peng Guo Yang Du Rong-Yan Zhu Zhao Jin Ya-Jie Wang Xiao-Min Wang Piu Chan Sheng-Di Chen Yong-Jun Wang Wei Zhang Serotonergic dysfunctions and abnormal iron metabolism: Relevant to mental fatigue of Parkinson disease |
| description |
Abstract Fatigue is a very common non-motor symptom in Parkinson disease (PD) patients. It included physical fatigue and mental fatigue. The potential mechanisms of mental fatigue involving serotonergic dysfunction and abnormal iron metabolism are still unknown. Therefore, we evaluated the fatigue symptoms, classified PD patients into fatigue group and non-fatigue group, and detected the levels of serotonin, iron and related proteins in CSF and serum. In CSF, 5-HT level is significantly decreased and the levels of iron and transferrin are dramatically increased in fatigue group. In fatigue group, mental fatigue score is negatively correlated with 5-HT level in CSF, and positively correlated with the scores of depression and excessive daytime sleepiness, and disease duration, also, mental fatigue is positively correlated with the levels of iron and transferrin in CSF. Transferrin level is negatively correlated with 5-HT level in CSF. In serum, the levels of 5-HT and transferrin are markedly decreased in fatigue group; mental fatigue score exhibits a negative correlation with 5-HT level. Thus serotonin dysfunction in both central and peripheral systems may be correlated with mental fatigue through abnormal iron metabolism. Depression, excessive daytime sleepiness and disease duration were the risk factors for mental fatigue of PD. |
| format |
article |
| author |
Li-Jun Zuo Shu-Yang Yu Yang Hu Fang Wang Ying-Shan Piao Teng-Hong Lian Qiu-Jin Yu Rui-Dan Wang Li-Xia Li Peng Guo Yang Du Rong-Yan Zhu Zhao Jin Ya-Jie Wang Xiao-Min Wang Piu Chan Sheng-Di Chen Yong-Jun Wang Wei Zhang |
| author_facet |
Li-Jun Zuo Shu-Yang Yu Yang Hu Fang Wang Ying-Shan Piao Teng-Hong Lian Qiu-Jin Yu Rui-Dan Wang Li-Xia Li Peng Guo Yang Du Rong-Yan Zhu Zhao Jin Ya-Jie Wang Xiao-Min Wang Piu Chan Sheng-Di Chen Yong-Jun Wang Wei Zhang |
| author_sort |
Li-Jun Zuo |
| title |
Serotonergic dysfunctions and abnormal iron metabolism: Relevant to mental fatigue of Parkinson disease |
| title_short |
Serotonergic dysfunctions and abnormal iron metabolism: Relevant to mental fatigue of Parkinson disease |
| title_full |
Serotonergic dysfunctions and abnormal iron metabolism: Relevant to mental fatigue of Parkinson disease |
| title_fullStr |
Serotonergic dysfunctions and abnormal iron metabolism: Relevant to mental fatigue of Parkinson disease |
| title_full_unstemmed |
Serotonergic dysfunctions and abnormal iron metabolism: Relevant to mental fatigue of Parkinson disease |
| title_sort |
serotonergic dysfunctions and abnormal iron metabolism: relevant to mental fatigue of parkinson disease |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/18f144a2c18a4488a18ddb67fe445f75 |
| work_keys_str_mv |
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| _version_ |
1718388563260735488 |