Pharmacokinetics of hydrogen after ingesting a hydrogen-rich solution: A study in pigs

Drinking hydrogen (H2)-rich water is a common way to consume H2. Although many studies have shown efficacy of drinking H2-rich water in neuropsychiatric and endocrine metabolic disorders, their authenticity has been questioned because none examined the associated pharmacokinetics of H2. Therefore, w...

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Autores principales:	Genki Ichihara, Yoshinori Katsumata, Hidenori Moriyama, Hiroki Kitakata, Akeo Hirai, Mizuki Momoi, Seien Ko, Yoshiki Shinya, Kenichiro Kinouchi, Eiji Kobayashi, Motoaki Sano
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Animal experimentation Translational medical research Catheterization Portal venous blood sampling Cannulation into the jejunal vein Science (General) Q1-390 Social sciences (General) H1-99
Acceso en línea:	https://doaj.org/article/18f1ce5df400448887a9371e6b6b7ca3
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spelling	oai:doaj.org-article:18f1ce5df400448887a9371e6b6b7ca32021-12-02T05:02:50ZPharmacokinetics of hydrogen after ingesting a hydrogen-rich solution: A study in pigs2405-844010.1016/j.heliyon.2021.e08359https://doaj.org/article/18f1ce5df400448887a9371e6b6b7ca32021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2405844021024622https://doaj.org/toc/2405-8440Drinking hydrogen (H2)-rich water is a common way to consume H2. Although many studies have shown efficacy of drinking H2-rich water in neuropsychiatric and endocrine metabolic disorders, their authenticity has been questioned because none examined the associated pharmacokinetics of H2. Therefore, we performed the first study to investigate the pharmacokinetics of H2 in pigs given an H2-rich glucose solution with the aim to extrapolate the findings to humans. We inserted blood collection catheters into the jejunal and portal veins, suprahepatic inferior vena cava, and carotid artery of 4 female pigs aged 8 weeks. Then, within 2 min we infused 500 ml of either H2-rich or H2-free glucose solution into the jejunum via a percutaneous gastrostomy tube and measured changes in H2 concentration in venous and arterial blood over 120 min. After infusion of the H2-rich glucose solution, H2 concentration in the portal vein peaked at 0.05 mg/L and remained at more than 0.016 mg/L (H2 saturation level, 1%) after 1 h; it also increased after infusion of H2-free glucose solution but remained below 0.001 mg/L (H2 saturation level, 0.06%). We assume that H2 was subsequently metabolized in the liver or eliminated via the lungs because it was not detected in the carotid artery. In conclusion, drinking highly concentrated H2-rich solution within a short time is a good way to increase H2 concentration in portal blood and supply H2 to the liver.Genki IchiharaYoshinori KatsumataHidenori MoriyamaHiroki KitakataAkeo HiraiMizuki MomoiSeien KoYoshiki ShinyaKenichiro KinouchiEiji KobayashiMotoaki SanoElsevierarticleAnimal experimentationTranslational medical researchCatheterizationPortal venous blood samplingCannulation into the jejunal veinScience (General)Q1-390Social sciences (General)H1-99ENHeliyon, Vol 7, Iss 11, Pp e08359- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Animal experimentation Translational medical research Catheterization Portal venous blood sampling Cannulation into the jejunal vein Science (General) Q1-390 Social sciences (General) H1-99
spellingShingle	Animal experimentation Translational medical research Catheterization Portal venous blood sampling Cannulation into the jejunal vein Science (General) Q1-390 Social sciences (General) H1-99 Genki Ichihara Yoshinori Katsumata Hidenori Moriyama Hiroki Kitakata Akeo Hirai Mizuki Momoi Seien Ko Yoshiki Shinya Kenichiro Kinouchi Eiji Kobayashi Motoaki Sano Pharmacokinetics of hydrogen after ingesting a hydrogen-rich solution: A study in pigs
description	Drinking hydrogen (H2)-rich water is a common way to consume H2. Although many studies have shown efficacy of drinking H2-rich water in neuropsychiatric and endocrine metabolic disorders, their authenticity has been questioned because none examined the associated pharmacokinetics of H2. Therefore, we performed the first study to investigate the pharmacokinetics of H2 in pigs given an H2-rich glucose solution with the aim to extrapolate the findings to humans. We inserted blood collection catheters into the jejunal and portal veins, suprahepatic inferior vena cava, and carotid artery of 4 female pigs aged 8 weeks. Then, within 2 min we infused 500 ml of either H2-rich or H2-free glucose solution into the jejunum via a percutaneous gastrostomy tube and measured changes in H2 concentration in venous and arterial blood over 120 min. After infusion of the H2-rich glucose solution, H2 concentration in the portal vein peaked at 0.05 mg/L and remained at more than 0.016 mg/L (H2 saturation level, 1%) after 1 h; it also increased after infusion of H2-free glucose solution but remained below 0.001 mg/L (H2 saturation level, 0.06%). We assume that H2 was subsequently metabolized in the liver or eliminated via the lungs because it was not detected in the carotid artery. In conclusion, drinking highly concentrated H2-rich solution within a short time is a good way to increase H2 concentration in portal blood and supply H2 to the liver.
format	article
author	Genki Ichihara Yoshinori Katsumata Hidenori Moriyama Hiroki Kitakata Akeo Hirai Mizuki Momoi Seien Ko Yoshiki Shinya Kenichiro Kinouchi Eiji Kobayashi Motoaki Sano
author_facet	Genki Ichihara Yoshinori Katsumata Hidenori Moriyama Hiroki Kitakata Akeo Hirai Mizuki Momoi Seien Ko Yoshiki Shinya Kenichiro Kinouchi Eiji Kobayashi Motoaki Sano
author_sort	Genki Ichihara
title	Pharmacokinetics of hydrogen after ingesting a hydrogen-rich solution: A study in pigs
title_short	Pharmacokinetics of hydrogen after ingesting a hydrogen-rich solution: A study in pigs
title_full	Pharmacokinetics of hydrogen after ingesting a hydrogen-rich solution: A study in pigs
title_fullStr	Pharmacokinetics of hydrogen after ingesting a hydrogen-rich solution: A study in pigs
title_full_unstemmed	Pharmacokinetics of hydrogen after ingesting a hydrogen-rich solution: A study in pigs
title_sort	pharmacokinetics of hydrogen after ingesting a hydrogen-rich solution: a study in pigs
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/18f1ce5df400448887a9371e6b6b7ca3
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Pharmacokinetics of hydrogen after ingesting a hydrogen-rich solution: A study in pigs

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