Apico-basal cell compression regulates Lamin A/C levels in epithelial tissues

The nuclear lamina bridges mechanical forces from the cytoskeleton to the nucleus, and while Lamin A/C is known to be crucial for this process, its regulation remains unclear. Here the authors show that levels of Lamin A/C scale with apico-basal compression of cells independently of tissue stiffness...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	K. Venkatesan Iyer, Anna Taubenberger, Salma Ahmed Zeidan, Natalie A. Dye, Suzanne Eaton, Frank Jülicher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/18f3dcd5533444a8967fe0f8c7d3ec46
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:18f3dcd5533444a8967fe0f8c7d3ec46
record_format	dspace
spelling	oai:doaj.org-article:18f3dcd5533444a8967fe0f8c7d3ec462021-12-02T11:44:56ZApico-basal cell compression regulates Lamin A/C levels in epithelial tissues10.1038/s41467-021-22010-92041-1723https://doaj.org/article/18f3dcd5533444a8967fe0f8c7d3ec462021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22010-9https://doaj.org/toc/2041-1723The nuclear lamina bridges mechanical forces from the cytoskeleton to the nucleus, and while Lamin A/C is known to be crucial for this process, its regulation remains unclear. Here the authors show that levels of Lamin A/C scale with apico-basal compression of cells independently of tissue stiffness using Drosophila epithelial tissues and mammalian cells.K. Venkatesan IyerAnna TaubenbergerSalma Ahmed ZeidanNatalie A. DyeSuzanne EatonFrank JülicherNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q K. Venkatesan Iyer Anna Taubenberger Salma Ahmed Zeidan Natalie A. Dye Suzanne Eaton Frank Jülicher Apico-basal cell compression regulates Lamin A/C levels in epithelial tissues
description	The nuclear lamina bridges mechanical forces from the cytoskeleton to the nucleus, and while Lamin A/C is known to be crucial for this process, its regulation remains unclear. Here the authors show that levels of Lamin A/C scale with apico-basal compression of cells independently of tissue stiffness using Drosophila epithelial tissues and mammalian cells.
format	article
author	K. Venkatesan Iyer Anna Taubenberger Salma Ahmed Zeidan Natalie A. Dye Suzanne Eaton Frank Jülicher
author_facet	K. Venkatesan Iyer Anna Taubenberger Salma Ahmed Zeidan Natalie A. Dye Suzanne Eaton Frank Jülicher
author_sort	K. Venkatesan Iyer
title	Apico-basal cell compression regulates Lamin A/C levels in epithelial tissues
title_short	Apico-basal cell compression regulates Lamin A/C levels in epithelial tissues
title_full	Apico-basal cell compression regulates Lamin A/C levels in epithelial tissues
title_fullStr	Apico-basal cell compression regulates Lamin A/C levels in epithelial tissues
title_full_unstemmed	Apico-basal cell compression regulates Lamin A/C levels in epithelial tissues
title_sort	apico-basal cell compression regulates lamin a/c levels in epithelial tissues
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/18f3dcd5533444a8967fe0f8c7d3ec46
work_keys_str_mv	AT kvenkatesaniyer apicobasalcellcompressionregulateslaminaclevelsinepithelialtissues AT annataubenberger apicobasalcellcompressionregulateslaminaclevelsinepithelialtissues AT salmaahmedzeidan apicobasalcellcompressionregulateslaminaclevelsinepithelialtissues AT natalieadye apicobasalcellcompressionregulateslaminaclevelsinepithelialtissues AT suzanneeaton apicobasalcellcompressionregulateslaminaclevelsinepithelialtissues AT frankjulicher apicobasalcellcompressionregulateslaminaclevelsinepithelialtissues
_version_	1718395267568369664

Apico-basal cell compression regulates Lamin A/C levels in epithelial tissues

Ejemplares similares