Plasma levels of IL-6 in patients with untreated major depressive disorder: comparison with catecholamine metabolites

Reiji Yoshimura,1,* Taro Kishi,2,* Nakao Iwata2 1Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Fukuoka 8078555, Japan; 2Department of Psychiatry, Fujita Medical University, Toyoake Aichi 4701192, Japan*These authors contributed equally to this workCorresp...

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Autores principales:	Yoshimura R, Kishi T, Iwata N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Interleukin-6 3-methoxy-4-hydroxypheneylglycol homovanillic acid major depressive disorder Hamilton Rating Scale for Depression Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/18f4f185196d4ecbbb069589b685b569
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spelling	oai:doaj.org-article:18f4f185196d4ecbbb069589b685b5692021-12-02T03:27:25ZPlasma levels of IL-6 in patients with untreated major depressive disorder: comparison with catecholamine metabolites1178-2021https://doaj.org/article/18f4f185196d4ecbbb069589b685b5692019-09-01T00:00:00Zhttps://www.dovepress.com/plasma-levels-of-il-6-in-patients-with-untreated-major-depressive-diso-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Reiji Yoshimura,1,* Taro Kishi,2,* Nakao Iwata2 1Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Fukuoka 8078555, Japan; 2Department of Psychiatry, Fujita Medical University, Toyoake Aichi 4701192, Japan*These authors contributed equally to this workCorrespondence: Reiji YoshimuraDepartment of Psychiatry, University of Occupational and Environmental Health, Kitakyushu Fukuoka 8078555, JapanTell +81936917253Email yoshi621@med.uoeh-u.ac.jpObjective: IL-6 and catecholamines play roles in the pathophysiology of major depressive disorder (MDD).Aim: The present study investigated associations between plasma IL-6 and plasma catecholamine metabolites in patients with MDD.Participants and methods: A total of 148 patients (male/female 65/83, age 49.5±12.1 years) who met the criteria for MDD based on the Diagnostic and Statistical Manual of Mental Disorders IV and 40 participants as healthy controls (HC; male/female 23/17, age 44.0±10.5 years) were enrolled in the present study. Plasma levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) and homovanillic acid (HVA) were analyzed using high-performance liquid chromatography, and plasma IL-6 levels were measured using ELISA.Results: No correlations were observed among plasma IL-6 levels, MHPG levels, and HVA levels in patients with MDD. Plasma IL-6 levels in patients with MDD were significantly higher than in the HC. A positive correlation was found between plasma IL-6 levels and Hamilton Rating Scale for Depression-17 scores.Conclusion: No correlations existed between plasma IL-6 levels and plasma catecholamine metabolite levels in patients with MDD, and the severity of depressive state was related to plasma IL-6 levels in MDD.Keywords: IL-6, 3-methoxy-4-hydroxyphenylglycol, homovanillic acid, major depressive disorder, Hamilton Rating Scale for DepressionYoshimura RKishi TIwata NDove Medical PressarticleInterleukin-63-methoxy-4-hydroxypheneylglycolhomovanillic acidmajor depressive disorderHamilton Rating Scale for DepressionNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 2655-2661 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Interleukin-6 3-methoxy-4-hydroxypheneylglycol homovanillic acid major depressive disorder Hamilton Rating Scale for Depression Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Interleukin-6 3-methoxy-4-hydroxypheneylglycol homovanillic acid major depressive disorder Hamilton Rating Scale for Depression Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Yoshimura R Kishi T Iwata N Plasma levels of IL-6 in patients with untreated major depressive disorder: comparison with catecholamine metabolites
description	Reiji Yoshimura,1,* Taro Kishi,2,* Nakao Iwata2 1Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Fukuoka 8078555, Japan; 2Department of Psychiatry, Fujita Medical University, Toyoake Aichi 4701192, Japan*These authors contributed equally to this workCorrespondence: Reiji YoshimuraDepartment of Psychiatry, University of Occupational and Environmental Health, Kitakyushu Fukuoka 8078555, JapanTell +81936917253Email yoshi621@med.uoeh-u.ac.jpObjective: IL-6 and catecholamines play roles in the pathophysiology of major depressive disorder (MDD).Aim: The present study investigated associations between plasma IL-6 and plasma catecholamine metabolites in patients with MDD.Participants and methods: A total of 148 patients (male/female 65/83, age 49.5±12.1 years) who met the criteria for MDD based on the Diagnostic and Statistical Manual of Mental Disorders IV and 40 participants as healthy controls (HC; male/female 23/17, age 44.0±10.5 years) were enrolled in the present study. Plasma levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) and homovanillic acid (HVA) were analyzed using high-performance liquid chromatography, and plasma IL-6 levels were measured using ELISA.Results: No correlations were observed among plasma IL-6 levels, MHPG levels, and HVA levels in patients with MDD. Plasma IL-6 levels in patients with MDD were significantly higher than in the HC. A positive correlation was found between plasma IL-6 levels and Hamilton Rating Scale for Depression-17 scores.Conclusion: No correlations existed between plasma IL-6 levels and plasma catecholamine metabolite levels in patients with MDD, and the severity of depressive state was related to plasma IL-6 levels in MDD.Keywords: IL-6, 3-methoxy-4-hydroxyphenylglycol, homovanillic acid, major depressive disorder, Hamilton Rating Scale for Depression
format	article
author	Yoshimura R Kishi T Iwata N
author_facet	Yoshimura R Kishi T Iwata N
author_sort	Yoshimura R
title	Plasma levels of IL-6 in patients with untreated major depressive disorder: comparison with catecholamine metabolites
title_short	Plasma levels of IL-6 in patients with untreated major depressive disorder: comparison with catecholamine metabolites
title_full	Plasma levels of IL-6 in patients with untreated major depressive disorder: comparison with catecholamine metabolites
title_fullStr	Plasma levels of IL-6 in patients with untreated major depressive disorder: comparison with catecholamine metabolites
title_full_unstemmed	Plasma levels of IL-6 in patients with untreated major depressive disorder: comparison with catecholamine metabolites
title_sort	plasma levels of il-6 in patients with untreated major depressive disorder: comparison with catecholamine metabolites
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/18f4f185196d4ecbbb069589b685b569
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Plasma levels of IL-6 in patients with untreated major depressive disorder: comparison with catecholamine metabolites

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