Simultaneous identification of multiple driver pathways in cancer.

Distinguishing the somatic mutations responsible for cancer (driver mutations) from random, passenger mutations is a key challenge in cancer genomics. Driver mutations generally target cellular signaling and regulatory pathways consisting of multiple genes. This heterogeneity complicates the identif...

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Autores principales: Mark D M Leiserson, Dima Blokh, Roded Sharan, Benjamin J Raphael
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/18f6e798e1c848eeb0f54886920e4b89
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