Patterns of viral pathogens causing upper respiratory tract infections among symptomatic children in Mwanza, Tanzania

Abstract Upper-respiratory tract infections (URTI) are the leading causes of childhood morbidities. This study investigated etiologies and patterns of URTI among children in Mwanza, Tanzania. A cross-sectional study involving 339 children was conducted between October-2017 and February-2018. Childre...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Elizabeth Kwiyolecha, Britta Groendahl, Bernard Okamo, Neema Kayange, Festo Manyama, Benson R. Kidenya, Dina C. Mahamba, Delfina R. Msanga, Stephan Gehring, Mtebe Majigo, Stephen E. Mshana, Mariam M. Mirambo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/18f92e32c24a496fb6336d2269eddc3b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:18f92e32c24a496fb6336d2269eddc3b
record_format	dspace
spelling	oai:doaj.org-article:18f92e32c24a496fb6336d2269eddc3b2021-12-02T15:09:41ZPatterns of viral pathogens causing upper respiratory tract infections among symptomatic children in Mwanza, Tanzania10.1038/s41598-020-74555-22045-2322https://doaj.org/article/18f92e32c24a496fb6336d2269eddc3b2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-74555-2https://doaj.org/toc/2045-2322Abstract Upper-respiratory tract infections (URTI) are the leading causes of childhood morbidities. This study investigated etiologies and patterns of URTI among children in Mwanza, Tanzania. A cross-sectional study involving 339 children was conducted between October-2017 and February-2018. Children with features suggestive of URTI such as nasal congestion, dry cough, painful swallowing and nasal discharge with/without fever were enrolled. Pathogens were detected from nasopharyngeal and ear-swabs by multiplex-PCR and culture respectively. Full blood count and C-reactive protein analysis were also done. The median age was 16 (IQR: 8–34) months. Majority (82.3%) had fever and nasal-congestion (65.5%). Rhinitis (55.9%) was the commonest diagnosis followed by pharyngitis (19.5%). Viruses were isolated in 46% of children, the commonest being Rhinoviruses (23.9%). Nineteen percent of children had more than 2 viruses; Rhinovirus and Enterovirus being the commonest combination. The commonest bacteria isolated from ears were Staphylococcus aureus and Pseudomonas aeruginosa. Children with viral pathogens had significantly right shift of lymphocytes (73%—sensitivity). Majority (257/339) of children were symptoms free on eighth day. Viruses are the commonest cause of URTI with Rhinitis being the common diagnosis. Rapid diagnostic assays for URTI pathogens are urgently needed in low-income countries to reduce unnecessary antibiotic prescriptions which is associated with antibiotic resistance.Elizabeth KwiyolechaBritta GroendahlBernard OkamoNeema KayangeFesto ManyamaBenson R. KidenyaDina C. MahambaDelfina R. MsangaStephan GehringMtebe MajigoStephen E. MshanaMariam M. MiramboNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elizabeth Kwiyolecha Britta Groendahl Bernard Okamo Neema Kayange Festo Manyama Benson R. Kidenya Dina C. Mahamba Delfina R. Msanga Stephan Gehring Mtebe Majigo Stephen E. Mshana Mariam M. Mirambo Patterns of viral pathogens causing upper respiratory tract infections among symptomatic children in Mwanza, Tanzania
description	Abstract Upper-respiratory tract infections (URTI) are the leading causes of childhood morbidities. This study investigated etiologies and patterns of URTI among children in Mwanza, Tanzania. A cross-sectional study involving 339 children was conducted between October-2017 and February-2018. Children with features suggestive of URTI such as nasal congestion, dry cough, painful swallowing and nasal discharge with/without fever were enrolled. Pathogens were detected from nasopharyngeal and ear-swabs by multiplex-PCR and culture respectively. Full blood count and C-reactive protein analysis were also done. The median age was 16 (IQR: 8–34) months. Majority (82.3%) had fever and nasal-congestion (65.5%). Rhinitis (55.9%) was the commonest diagnosis followed by pharyngitis (19.5%). Viruses were isolated in 46% of children, the commonest being Rhinoviruses (23.9%). Nineteen percent of children had more than 2 viruses; Rhinovirus and Enterovirus being the commonest combination. The commonest bacteria isolated from ears were Staphylococcus aureus and Pseudomonas aeruginosa. Children with viral pathogens had significantly right shift of lymphocytes (73%—sensitivity). Majority (257/339) of children were symptoms free on eighth day. Viruses are the commonest cause of URTI with Rhinitis being the common diagnosis. Rapid diagnostic assays for URTI pathogens are urgently needed in low-income countries to reduce unnecessary antibiotic prescriptions which is associated with antibiotic resistance.
format	article
author	Elizabeth Kwiyolecha Britta Groendahl Bernard Okamo Neema Kayange Festo Manyama Benson R. Kidenya Dina C. Mahamba Delfina R. Msanga Stephan Gehring Mtebe Majigo Stephen E. Mshana Mariam M. Mirambo
author_facet	Elizabeth Kwiyolecha Britta Groendahl Bernard Okamo Neema Kayange Festo Manyama Benson R. Kidenya Dina C. Mahamba Delfina R. Msanga Stephan Gehring Mtebe Majigo Stephen E. Mshana Mariam M. Mirambo
author_sort	Elizabeth Kwiyolecha
title	Patterns of viral pathogens causing upper respiratory tract infections among symptomatic children in Mwanza, Tanzania
title_short	Patterns of viral pathogens causing upper respiratory tract infections among symptomatic children in Mwanza, Tanzania
title_full	Patterns of viral pathogens causing upper respiratory tract infections among symptomatic children in Mwanza, Tanzania
title_fullStr	Patterns of viral pathogens causing upper respiratory tract infections among symptomatic children in Mwanza, Tanzania
title_full_unstemmed	Patterns of viral pathogens causing upper respiratory tract infections among symptomatic children in Mwanza, Tanzania
title_sort	patterns of viral pathogens causing upper respiratory tract infections among symptomatic children in mwanza, tanzania
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/18f92e32c24a496fb6336d2269eddc3b
work_keys_str_mv	AT elizabethkwiyolecha patternsofviralpathogenscausingupperrespiratorytractinfectionsamongsymptomaticchildreninmwanzatanzania AT brittagroendahl patternsofviralpathogenscausingupperrespiratorytractinfectionsamongsymptomaticchildreninmwanzatanzania AT bernardokamo patternsofviralpathogenscausingupperrespiratorytractinfectionsamongsymptomaticchildreninmwanzatanzania AT neemakayange patternsofviralpathogenscausingupperrespiratorytractinfectionsamongsymptomaticchildreninmwanzatanzania AT festomanyama patternsofviralpathogenscausingupperrespiratorytractinfectionsamongsymptomaticchildreninmwanzatanzania AT bensonrkidenya patternsofviralpathogenscausingupperrespiratorytractinfectionsamongsymptomaticchildreninmwanzatanzania AT dinacmahamba patternsofviralpathogenscausingupperrespiratorytractinfectionsamongsymptomaticchildreninmwanzatanzania AT delfinarmsanga patternsofviralpathogenscausingupperrespiratorytractinfectionsamongsymptomaticchildreninmwanzatanzania AT stephangehring patternsofviralpathogenscausingupperrespiratorytractinfectionsamongsymptomaticchildreninmwanzatanzania AT mtebemajigo patternsofviralpathogenscausingupperrespiratorytractinfectionsamongsymptomaticchildreninmwanzatanzania AT stephenemshana patternsofviralpathogenscausingupperrespiratorytractinfectionsamongsymptomaticchildreninmwanzatanzania AT mariammmirambo patternsofviralpathogenscausingupperrespiratorytractinfectionsamongsymptomaticchildreninmwanzatanzania
_version_	1718387736849678336

Patterns of viral pathogens causing upper respiratory tract infections among symptomatic children in Mwanza, Tanzania

Ejemplares similares