Patient-specific factors influence somatic variation patterns in von Hippel–Lindau disease renal tumours

Analysing multiple tumours from the same patient permits the study of the germline contribution to cancer. Here, the authors sequence multiple renal tumours from VHL patients and find that intra-patient tumours are clonally distinct but share some genetic features, suggesting that patient-specific f...

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Autores principales:	Suzanne S. Fei, Asia D. Mitchell, Michael B. Heskett, Cathy D. Vocke, Christopher J. Ricketts, Myron Peto, Nicholas J. Wang, Kemal Sönmez, W. Marston Linehan, Paul T. Spellman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/18f99ca8ada94e7ca0e00a7053663d5b
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spelling	oai:doaj.org-article:18f99ca8ada94e7ca0e00a7053663d5b2021-12-02T16:57:29ZPatient-specific factors influence somatic variation patterns in von Hippel–Lindau disease renal tumours10.1038/ncomms115882041-1723https://doaj.org/article/18f99ca8ada94e7ca0e00a7053663d5b2016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11588https://doaj.org/toc/2041-1723Analysing multiple tumours from the same patient permits the study of the germline contribution to cancer. Here, the authors sequence multiple renal tumours from VHL patients and find that intra-patient tumours are clonally distinct but share some genetic features, suggesting that patient-specific factors influence tumour formation.Suzanne S. FeiAsia D. MitchellMichael B. HeskettCathy D. VockeChristopher J. RickettsMyron PetoNicholas J. WangKemal SönmezW. Marston LinehanPaul T. SpellmanNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Suzanne S. Fei Asia D. Mitchell Michael B. Heskett Cathy D. Vocke Christopher J. Ricketts Myron Peto Nicholas J. Wang Kemal Sönmez W. Marston Linehan Paul T. Spellman Patient-specific factors influence somatic variation patterns in von Hippel–Lindau disease renal tumours
description	Analysing multiple tumours from the same patient permits the study of the germline contribution to cancer. Here, the authors sequence multiple renal tumours from VHL patients and find that intra-patient tumours are clonally distinct but share some genetic features, suggesting that patient-specific factors influence tumour formation.
format	article
author	Suzanne S. Fei Asia D. Mitchell Michael B. Heskett Cathy D. Vocke Christopher J. Ricketts Myron Peto Nicholas J. Wang Kemal Sönmez W. Marston Linehan Paul T. Spellman
author_facet	Suzanne S. Fei Asia D. Mitchell Michael B. Heskett Cathy D. Vocke Christopher J. Ricketts Myron Peto Nicholas J. Wang Kemal Sönmez W. Marston Linehan Paul T. Spellman
author_sort	Suzanne S. Fei
title	Patient-specific factors influence somatic variation patterns in von Hippel–Lindau disease renal tumours
title_short	Patient-specific factors influence somatic variation patterns in von Hippel–Lindau disease renal tumours
title_full	Patient-specific factors influence somatic variation patterns in von Hippel–Lindau disease renal tumours
title_fullStr	Patient-specific factors influence somatic variation patterns in von Hippel–Lindau disease renal tumours
title_full_unstemmed	Patient-specific factors influence somatic variation patterns in von Hippel–Lindau disease renal tumours
title_sort	patient-specific factors influence somatic variation patterns in von hippel–lindau disease renal tumours
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/18f99ca8ada94e7ca0e00a7053663d5b
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Patient-specific factors influence somatic variation patterns in von Hippel–Lindau disease renal tumours

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