L-carnitine supplementation descreases hepatic triglyceride accumulation in Holstein cows during the transition period

Background: The increased use of body reserves observed during peripartum leads to higher needs of L-carnitine by cows, which is restrictive under the production conditions of Colombian high tropics. Objective: To evaluate the lipotropic potential of L-carnitine in Holstein dairy cows during the tra...

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Autores principales:	Rubén D. Galvis, Liset V. Madrid, Nicolás Ramírez-Vásquez
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2019
Materias:	dairy cows lipid metabolism l-carnitine lipidosis lipotropic factors metabolic disorders peripartum Animal culture SF1-1100
Acceso en línea:	https://doaj.org/article/18fb5c262fc141e8ba41f6d64e658584
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spelling	oai:doaj.org-article:18fb5c262fc141e8ba41f6d64e6585842021-12-01T18:49:31ZL-carnitine supplementation descreases hepatic triglyceride accumulation in Holstein cows during the transition period2256-295810.17533/udea.rccp.v32n3a01https://doaj.org/article/18fb5c262fc141e8ba41f6d64e6585842019-07-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/rccp/article/view/337875https://doaj.org/toc/2256-2958Background: The increased use of body reserves observed during peripartum leads to higher needs of L-carnitine by cows, which is restrictive under the production conditions of Colombian high tropics. Objective: To evaluate the lipotropic potential of L-carnitine in Holstein dairy cows during the transition period to lactation. Methods: Twenty-one Holstein cows were fed 0, 100, or 200 g/d L-carnitine fumarate from d 260 of gestation to d 20 postpartum. Hepatic triacylglycerides concentration, total carnitine, free carnitine, acylcarnitine, and serum levels of non-esterified fatty acids (NEFA), β-hydroxybutyrate (β-HB) and urea were determined by spectrophotometry. Repeated measures analysis was used to determine the effects of dose, measurement period, and their interactions. Results: Hepatic triglycerides and the different forms of carnitine showed no difference between sampling periods (p>0.05). Hepatic triglycerides concentration was low and decreased in response to 200 g/d L-carnitine fumarate supplementation (p<0.05). This decrease in hepatic triglycerides could be due to increased fatty acid oxidation. L-carnitine supplementation significantly increased (p<0.05) blood urea concentration, possibly through stimulation of the urea cycle, as previously described in other species. Conclusion: Supplementation with L-carnitine decreased the hepatic concentration of triglycerides, possibly due to increased liver oxidation of fatty acids.Rubén D. GalvisLiset V. MadridNicolás Ramírez-VásquezUniversidad de Antioquiaarticledairy cowslipid metabolisml-carnitinelipidosislipotropic factorsmetabolic disordersperipartumAnimal cultureSF1-1100ENRevista Colombiana de Ciencias Pecuarias, Vol 32, Iss 3, Pp 166-174 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	dairy cows lipid metabolism l-carnitine lipidosis lipotropic factors metabolic disorders peripartum Animal culture SF1-1100
spellingShingle	dairy cows lipid metabolism l-carnitine lipidosis lipotropic factors metabolic disorders peripartum Animal culture SF1-1100 Rubén D. Galvis Liset V. Madrid Nicolás Ramírez-Vásquez L-carnitine supplementation descreases hepatic triglyceride accumulation in Holstein cows during the transition period
description	Background: The increased use of body reserves observed during peripartum leads to higher needs of L-carnitine by cows, which is restrictive under the production conditions of Colombian high tropics. Objective: To evaluate the lipotropic potential of L-carnitine in Holstein dairy cows during the transition period to lactation. Methods: Twenty-one Holstein cows were fed 0, 100, or 200 g/d L-carnitine fumarate from d 260 of gestation to d 20 postpartum. Hepatic triacylglycerides concentration, total carnitine, free carnitine, acylcarnitine, and serum levels of non-esterified fatty acids (NEFA), β-hydroxybutyrate (β-HB) and urea were determined by spectrophotometry. Repeated measures analysis was used to determine the effects of dose, measurement period, and their interactions. Results: Hepatic triglycerides and the different forms of carnitine showed no difference between sampling periods (p>0.05). Hepatic triglycerides concentration was low and decreased in response to 200 g/d L-carnitine fumarate supplementation (p<0.05). This decrease in hepatic triglycerides could be due to increased fatty acid oxidation. L-carnitine supplementation significantly increased (p<0.05) blood urea concentration, possibly through stimulation of the urea cycle, as previously described in other species. Conclusion: Supplementation with L-carnitine decreased the hepatic concentration of triglycerides, possibly due to increased liver oxidation of fatty acids.
format	article
author	Rubén D. Galvis Liset V. Madrid Nicolás Ramírez-Vásquez
author_facet	Rubén D. Galvis Liset V. Madrid Nicolás Ramírez-Vásquez
author_sort	Rubén D. Galvis
title	L-carnitine supplementation descreases hepatic triglyceride accumulation in Holstein cows during the transition period
title_short	L-carnitine supplementation descreases hepatic triglyceride accumulation in Holstein cows during the transition period
title_full	L-carnitine supplementation descreases hepatic triglyceride accumulation in Holstein cows during the transition period
title_fullStr	L-carnitine supplementation descreases hepatic triglyceride accumulation in Holstein cows during the transition period
title_full_unstemmed	L-carnitine supplementation descreases hepatic triglyceride accumulation in Holstein cows during the transition period
title_sort	l-carnitine supplementation descreases hepatic triglyceride accumulation in holstein cows during the transition period
publisher	Universidad de Antioquia
publishDate	2019
url	https://doaj.org/article/18fb5c262fc141e8ba41f6d64e658584
work_keys_str_mv	AT rubendgalvis lcarnitinesupplementationdescreaseshepatictriglycerideaccumulationinholsteincowsduringthetransitionperiod AT lisetvmadrid lcarnitinesupplementationdescreaseshepatictriglycerideaccumulationinholsteincowsduringthetransitionperiod AT nicolasramirezvasquez lcarnitinesupplementationdescreaseshepatictriglycerideaccumulationinholsteincowsduringthetransitionperiod
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L-carnitine supplementation descreases hepatic triglyceride accumulation in Holstein cows during the transition period

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