The human nucleoporin Tpr protects cells from RNA-mediated replication stress

Tpr nucleoporin is known to be essential for nuclear transport and mitosis processes. Here the authors explore the link between Tpr and genome instability providing insights into the role of Tpr in safeguarding cells from RNA-mediated replication stress.

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Autores principales: Martin Kosar, Michele Giannattasio, Daniele Piccini, Apolinar Maya-Mendoza, Francisco García-Benítez, Jirina Bartkova, Sonia I. Barroso, Hélène Gaillard, Emanuele Martini, Umberto Restuccia, Miguel Angel Ramirez-Otero, Massimiliano Garre, Eleonora Verga, Miguel Andújar-Sánchez, Scott Maynard, Zdenek Hodny, Vincenzo Costanzo, Amit Kumar, Angela Bachi, Andrés Aguilera, Jiri Bartek, Marco Foiani
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/18fbf66c3f8442a6835b1d14c7f9ffa2
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spelling oai:doaj.org-article:18fbf66c3f8442a6835b1d14c7f9ffa22021-12-02T16:05:50ZThe human nucleoporin Tpr protects cells from RNA-mediated replication stress10.1038/s41467-021-24224-32041-1723https://doaj.org/article/18fbf66c3f8442a6835b1d14c7f9ffa22021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24224-3https://doaj.org/toc/2041-1723Tpr nucleoporin is known to be essential for nuclear transport and mitosis processes. Here the authors explore the link between Tpr and genome instability providing insights into the role of Tpr in safeguarding cells from RNA-mediated replication stress.Martin KosarMichele GiannattasioDaniele PicciniApolinar Maya-MendozaFrancisco García-BenítezJirina BartkovaSonia I. BarrosoHélène GaillardEmanuele MartiniUmberto RestucciaMiguel Angel Ramirez-OteroMassimiliano GarreEleonora VergaMiguel Andújar-SánchezScott MaynardZdenek HodnyVincenzo CostanzoAmit KumarAngela BachiAndrés AguileraJiri BartekMarco FoianiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Martin Kosar
Michele Giannattasio
Daniele Piccini
Apolinar Maya-Mendoza
Francisco García-Benítez
Jirina Bartkova
Sonia I. Barroso
Hélène Gaillard
Emanuele Martini
Umberto Restuccia
Miguel Angel Ramirez-Otero
Massimiliano Garre
Eleonora Verga
Miguel Andújar-Sánchez
Scott Maynard
Zdenek Hodny
Vincenzo Costanzo
Amit Kumar
Angela Bachi
Andrés Aguilera
Jiri Bartek
Marco Foiani
The human nucleoporin Tpr protects cells from RNA-mediated replication stress
description Tpr nucleoporin is known to be essential for nuclear transport and mitosis processes. Here the authors explore the link between Tpr and genome instability providing insights into the role of Tpr in safeguarding cells from RNA-mediated replication stress.
format article
author Martin Kosar
Michele Giannattasio
Daniele Piccini
Apolinar Maya-Mendoza
Francisco García-Benítez
Jirina Bartkova
Sonia I. Barroso
Hélène Gaillard
Emanuele Martini
Umberto Restuccia
Miguel Angel Ramirez-Otero
Massimiliano Garre
Eleonora Verga
Miguel Andújar-Sánchez
Scott Maynard
Zdenek Hodny
Vincenzo Costanzo
Amit Kumar
Angela Bachi
Andrés Aguilera
Jiri Bartek
Marco Foiani
author_facet Martin Kosar
Michele Giannattasio
Daniele Piccini
Apolinar Maya-Mendoza
Francisco García-Benítez
Jirina Bartkova
Sonia I. Barroso
Hélène Gaillard
Emanuele Martini
Umberto Restuccia
Miguel Angel Ramirez-Otero
Massimiliano Garre
Eleonora Verga
Miguel Andújar-Sánchez
Scott Maynard
Zdenek Hodny
Vincenzo Costanzo
Amit Kumar
Angela Bachi
Andrés Aguilera
Jiri Bartek
Marco Foiani
author_sort Martin Kosar
title The human nucleoporin Tpr protects cells from RNA-mediated replication stress
title_short The human nucleoporin Tpr protects cells from RNA-mediated replication stress
title_full The human nucleoporin Tpr protects cells from RNA-mediated replication stress
title_fullStr The human nucleoporin Tpr protects cells from RNA-mediated replication stress
title_full_unstemmed The human nucleoporin Tpr protects cells from RNA-mediated replication stress
title_sort human nucleoporin tpr protects cells from rna-mediated replication stress
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/18fbf66c3f8442a6835b1d14c7f9ffa2
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