Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children.

High proportions of autistic children suffer from gastrointestinal (GI) disorders, implying a link between autism and abnormalities in gut microbial functions. Increasing evidence from recent high-throughput sequencing analyses indicates that disturbances in composition and diversity of gut microbio...

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Autores principales:	Dae-Wook Kang, Jin Gyoon Park, Zehra Esra Ilhan, Garrick Wallstrom, Joshua Labaer, James B Adams, Rosa Krajmalnik-Brown
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1900e5d34a5846d5870a3f5dc23fd6ef
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spelling	oai:doaj.org-article:1900e5d34a5846d5870a3f5dc23fd6ef2021-11-18T07:38:45ZReduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children.1932-620310.1371/journal.pone.0068322https://doaj.org/article/1900e5d34a5846d5870a3f5dc23fd6ef2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23844187/?tool=EBIhttps://doaj.org/toc/1932-6203High proportions of autistic children suffer from gastrointestinal (GI) disorders, implying a link between autism and abnormalities in gut microbial functions. Increasing evidence from recent high-throughput sequencing analyses indicates that disturbances in composition and diversity of gut microbiome are associated with various disease conditions. However, microbiome-level studies on autism are limited and mostly focused on pathogenic bacteria. Therefore, here we aimed to define systemic changes in gut microbiome associated with autism and autism-related GI problems. We recruited 20 neurotypical and 20 autistic children accompanied by a survey of both autistic severity and GI symptoms. By pyrosequencing the V2/V3 regions in bacterial 16S rDNA from fecal DNA samples, we compared gut microbiomes of GI symptom-free neurotypical children with those of autistic children mostly presenting GI symptoms. Unexpectedly, the presence of autistic symptoms, rather than the severity of GI symptoms, was associated with less diverse gut microbiomes. Further, rigorous statistical tests with multiple testing corrections showed significantly lower abundances of the genera Prevotella, Coprococcus, and unclassified Veillonellaceae in autistic samples. These are intriguingly versatile carbohydrate-degrading and/or fermenting bacteria, suggesting a potential influence of unusual diet patterns observed in autistic children. However, multivariate analyses showed that autism-related changes in both overall diversity and individual genus abundances were correlated with the presence of autistic symptoms but not with their diet patterns. Taken together, autism and accompanying GI symptoms were characterized by distinct and less diverse gut microbial compositions with lower levels of Prevotella, Coprococcus, and unclassified Veillonellaceae.Dae-Wook KangJin Gyoon ParkZehra Esra IlhanGarrick WallstromJoshua LabaerJames B AdamsRosa Krajmalnik-BrownPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 7, p e68322 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dae-Wook Kang Jin Gyoon Park Zehra Esra Ilhan Garrick Wallstrom Joshua Labaer James B Adams Rosa Krajmalnik-Brown Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children.
description	High proportions of autistic children suffer from gastrointestinal (GI) disorders, implying a link between autism and abnormalities in gut microbial functions. Increasing evidence from recent high-throughput sequencing analyses indicates that disturbances in composition and diversity of gut microbiome are associated with various disease conditions. However, microbiome-level studies on autism are limited and mostly focused on pathogenic bacteria. Therefore, here we aimed to define systemic changes in gut microbiome associated with autism and autism-related GI problems. We recruited 20 neurotypical and 20 autistic children accompanied by a survey of both autistic severity and GI symptoms. By pyrosequencing the V2/V3 regions in bacterial 16S rDNA from fecal DNA samples, we compared gut microbiomes of GI symptom-free neurotypical children with those of autistic children mostly presenting GI symptoms. Unexpectedly, the presence of autistic symptoms, rather than the severity of GI symptoms, was associated with less diverse gut microbiomes. Further, rigorous statistical tests with multiple testing corrections showed significantly lower abundances of the genera Prevotella, Coprococcus, and unclassified Veillonellaceae in autistic samples. These are intriguingly versatile carbohydrate-degrading and/or fermenting bacteria, suggesting a potential influence of unusual diet patterns observed in autistic children. However, multivariate analyses showed that autism-related changes in both overall diversity and individual genus abundances were correlated with the presence of autistic symptoms but not with their diet patterns. Taken together, autism and accompanying GI symptoms were characterized by distinct and less diverse gut microbial compositions with lower levels of Prevotella, Coprococcus, and unclassified Veillonellaceae.
format	article
author	Dae-Wook Kang Jin Gyoon Park Zehra Esra Ilhan Garrick Wallstrom Joshua Labaer James B Adams Rosa Krajmalnik-Brown
author_facet	Dae-Wook Kang Jin Gyoon Park Zehra Esra Ilhan Garrick Wallstrom Joshua Labaer James B Adams Rosa Krajmalnik-Brown
author_sort	Dae-Wook Kang
title	Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children.
title_short	Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children.
title_full	Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children.
title_fullStr	Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children.
title_full_unstemmed	Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children.
title_sort	reduced incidence of prevotella and other fermenters in intestinal microflora of autistic children.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/1900e5d34a5846d5870a3f5dc23fd6ef
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Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children.

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