High-speed mechano-active multielectrode array for investigating rapid stretch effects on cardiac tissue

While strain is known to affect cardiac electrophysiology, experimental systems to interrogate the effect of rapid strain cycles on cardiac tissue are lacking. Here the authors introduce a multielectrode array that can induce rapid dynamic strain cycles on cardiomyocyte strands and see effects of st...

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Autores principales: Matthias Imboden, Etienne de Coulon, Alexandre Poulin, Christian Dellenbach, Samuel Rosset, Herbert Shea, Stephan Rohr
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/1901c6b298734f24aab8bad39352e00c
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Sumario:While strain is known to affect cardiac electrophysiology, experimental systems to interrogate the effect of rapid strain cycles on cardiac tissue are lacking. Here the authors introduce a multielectrode array that can induce rapid dynamic strain cycles on cardiomyocyte strands and see effects of strain amplitude but not strain rate on impulse conduction.