Recurrence of the oxazole motif in tubulin colchicine site inhibitors with anti-tumor activity

Because of its wide spectrum of targets and biological activities, the oxazole ring is a valuable heterocyclic scaffold in the design of new therapeutic agents with anticancer, antiviral, antibacterial, anti-inflammatory, neuroprotective, antidiabetic and antidepressant properties. The presence of t...

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Autores principales:	Marilia Barreca, Virginia Spanò, Maria Valeria Raimondi, Chiara Tarantelli, Filippo Spriano, Francesco Bertoni, Paola Barraja, Alessandra Montalbano
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Oxazoles Anti-Tubulin agents Cancer Colchicine binding inhibitors Pharmacy and materia medica RS1-441 Other systems of medicine RZ201-999
Acceso en línea:	https://doaj.org/article/19046b374f964d0bb7731ec2a44064d5
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spelling	oai:doaj.org-article:19046b374f964d0bb7731ec2a44064d52021-12-03T04:01:36ZRecurrence of the oxazole motif in tubulin colchicine site inhibitors with anti-tumor activity2772-417410.1016/j.ejmcr.2021.100004https://doaj.org/article/19046b374f964d0bb7731ec2a44064d52021-07-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2772417421000042https://doaj.org/toc/2772-4174Because of its wide spectrum of targets and biological activities, the oxazole ring is a valuable heterocyclic scaffold in the design of new therapeutic agents with anticancer, antiviral, antibacterial, anti-inflammatory, neuroprotective, antidiabetic and antidepressant properties. The presence of two heteroatoms, oxygen and nitrogen, offers possible interactions (hydrogen, hydrophobic, van der Waals or dipoles bonds) with a broad range of receptors and enzymes. Furthermore, the oxazole core conjugates low cytotoxicity with improved compound solubility and is well suited to structural modifications such as substitution with different groups and condensation to aromatic, heteroaromatic or non-aromatic rings, offering diversity when introduced into scaffolds. These features make it a very attractive nucleus in medicinal chemistry.Herein we present a diverse array of oxazole derivatives with potential therapeutic use in multiple tumor models. The emphasis has been addressed to compounds with anti-tubulin activity reported in literature in the last decade, describing their structural features, efficiency and future perspectives.Marilia BarrecaVirginia SpanòMaria Valeria RaimondiChiara TarantelliFilippo SprianoFrancesco BertoniPaola BarrajaAlessandra MontalbanoElsevierarticleOxazolesAnti-Tubulin agentsCancerColchicine binding inhibitorsPharmacy and materia medicaRS1-441Other systems of medicineRZ201-999ENEuropean Journal of Medicinal Chemistry Reports, Vol 1, Iss , Pp 100004- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Oxazoles Anti-Tubulin agents Cancer Colchicine binding inhibitors Pharmacy and materia medica RS1-441 Other systems of medicine RZ201-999
spellingShingle	Oxazoles Anti-Tubulin agents Cancer Colchicine binding inhibitors Pharmacy and materia medica RS1-441 Other systems of medicine RZ201-999 Marilia Barreca Virginia Spanò Maria Valeria Raimondi Chiara Tarantelli Filippo Spriano Francesco Bertoni Paola Barraja Alessandra Montalbano Recurrence of the oxazole motif in tubulin colchicine site inhibitors with anti-tumor activity
description	Because of its wide spectrum of targets and biological activities, the oxazole ring is a valuable heterocyclic scaffold in the design of new therapeutic agents with anticancer, antiviral, antibacterial, anti-inflammatory, neuroprotective, antidiabetic and antidepressant properties. The presence of two heteroatoms, oxygen and nitrogen, offers possible interactions (hydrogen, hydrophobic, van der Waals or dipoles bonds) with a broad range of receptors and enzymes. Furthermore, the oxazole core conjugates low cytotoxicity with improved compound solubility and is well suited to structural modifications such as substitution with different groups and condensation to aromatic, heteroaromatic or non-aromatic rings, offering diversity when introduced into scaffolds. These features make it a very attractive nucleus in medicinal chemistry.Herein we present a diverse array of oxazole derivatives with potential therapeutic use in multiple tumor models. The emphasis has been addressed to compounds with anti-tubulin activity reported in literature in the last decade, describing their structural features, efficiency and future perspectives.
format	article
author	Marilia Barreca Virginia Spanò Maria Valeria Raimondi Chiara Tarantelli Filippo Spriano Francesco Bertoni Paola Barraja Alessandra Montalbano
author_facet	Marilia Barreca Virginia Spanò Maria Valeria Raimondi Chiara Tarantelli Filippo Spriano Francesco Bertoni Paola Barraja Alessandra Montalbano
author_sort	Marilia Barreca
title	Recurrence of the oxazole motif in tubulin colchicine site inhibitors with anti-tumor activity
title_short	Recurrence of the oxazole motif in tubulin colchicine site inhibitors with anti-tumor activity
title_full	Recurrence of the oxazole motif in tubulin colchicine site inhibitors with anti-tumor activity
title_fullStr	Recurrence of the oxazole motif in tubulin colchicine site inhibitors with anti-tumor activity
title_full_unstemmed	Recurrence of the oxazole motif in tubulin colchicine site inhibitors with anti-tumor activity
title_sort	recurrence of the oxazole motif in tubulin colchicine site inhibitors with anti-tumor activity
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/19046b374f964d0bb7731ec2a44064d5
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Recurrence of the oxazole motif in tubulin colchicine site inhibitors with anti-tumor activity

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