IDH1 mutations induce organelle defects via dysregulated phospholipids

The understanding of altered lipid metabolism by isocitrate dehydrogenase 1 (IDH1) mutations in gliomas at a compartment-specific level is limited. Here, the authors use Raman spectroscopy to monitor organelle-specific metabolic changes and report that IDH1 mutations induce phospholipid imbalances w...

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Autores principales:	Adrian Lita, Artem Pliss, Andrey Kuzmin, Tomohiro Yamasaki, Lumin Zhang, Tyrone Dowdy, Christina Burks, Natalia de Val, Orieta Celiku, Victor Ruiz-Rodado, Elena-Raluca Nicoli, Michael Kruhlak, Thorkell Andresson, Sudipto Das, Chunzhang Yang, Rebecca Schmitt, Christel Herold-Mende, Mark R. Gilbert, Paras N. Prasad, Mioara Larion
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1908125b7bca48998003ff46dab75493
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spelling	oai:doaj.org-article:1908125b7bca48998003ff46dab754932021-12-02T14:16:13ZIDH1 mutations induce organelle defects via dysregulated phospholipids10.1038/s41467-020-20752-62041-1723https://doaj.org/article/1908125b7bca48998003ff46dab754932021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20752-6https://doaj.org/toc/2041-1723The understanding of altered lipid metabolism by isocitrate dehydrogenase 1 (IDH1) mutations in gliomas at a compartment-specific level is limited. Here, the authors use Raman spectroscopy to monitor organelle-specific metabolic changes and report that IDH1 mutations induce phospholipid imbalances which lead to ER and Golgi dilation.Adrian LitaArtem PlissAndrey KuzminTomohiro YamasakiLumin ZhangTyrone DowdyChristina BurksNatalia de ValOrieta CelikuVictor Ruiz-RodadoElena-Raluca NicoliMichael KruhlakThorkell AndressonSudipto DasChunzhang YangRebecca SchmittChristel Herold-MendeMark R. GilbertParas N. PrasadMioara LarionNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Adrian Lita Artem Pliss Andrey Kuzmin Tomohiro Yamasaki Lumin Zhang Tyrone Dowdy Christina Burks Natalia de Val Orieta Celiku Victor Ruiz-Rodado Elena-Raluca Nicoli Michael Kruhlak Thorkell Andresson Sudipto Das Chunzhang Yang Rebecca Schmitt Christel Herold-Mende Mark R. Gilbert Paras N. Prasad Mioara Larion IDH1 mutations induce organelle defects via dysregulated phospholipids
description	The understanding of altered lipid metabolism by isocitrate dehydrogenase 1 (IDH1) mutations in gliomas at a compartment-specific level is limited. Here, the authors use Raman spectroscopy to monitor organelle-specific metabolic changes and report that IDH1 mutations induce phospholipid imbalances which lead to ER and Golgi dilation.
format	article
author	Adrian Lita Artem Pliss Andrey Kuzmin Tomohiro Yamasaki Lumin Zhang Tyrone Dowdy Christina Burks Natalia de Val Orieta Celiku Victor Ruiz-Rodado Elena-Raluca Nicoli Michael Kruhlak Thorkell Andresson Sudipto Das Chunzhang Yang Rebecca Schmitt Christel Herold-Mende Mark R. Gilbert Paras N. Prasad Mioara Larion
author_facet	Adrian Lita Artem Pliss Andrey Kuzmin Tomohiro Yamasaki Lumin Zhang Tyrone Dowdy Christina Burks Natalia de Val Orieta Celiku Victor Ruiz-Rodado Elena-Raluca Nicoli Michael Kruhlak Thorkell Andresson Sudipto Das Chunzhang Yang Rebecca Schmitt Christel Herold-Mende Mark R. Gilbert Paras N. Prasad Mioara Larion
author_sort	Adrian Lita
title	IDH1 mutations induce organelle defects via dysregulated phospholipids
title_short	IDH1 mutations induce organelle defects via dysregulated phospholipids
title_full	IDH1 mutations induce organelle defects via dysregulated phospholipids
title_fullStr	IDH1 mutations induce organelle defects via dysregulated phospholipids
title_full_unstemmed	IDH1 mutations induce organelle defects via dysregulated phospholipids
title_sort	idh1 mutations induce organelle defects via dysregulated phospholipids
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1908125b7bca48998003ff46dab75493
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IDH1 mutations induce organelle defects via dysregulated phospholipids

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