Differentiating peripheral cholangiocarcinoma in stages T1N0M0 and T2N0M0 from hepatic hypovascular nodules using dynamic contrast-enhanced MRI

Abstract Because cholangiocarcinoma shows no specific clinical signs or symptoms and presents with non-specific biological and tumor markers in the early stages, MRI findings often lack typical features before this lesion becomes symptomatic and might be mistaken for other liver lesions. An evaluati...

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Autores principales:	Shihong Li, Haizhen Qian, Yu Peng, Huihui Jia, Guangwu Lin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/190c8e96e1a7404c896b52a2499686e2
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spelling	oai:doaj.org-article:190c8e96e1a7404c896b52a2499686e22021-12-02T16:06:42ZDifferentiating peripheral cholangiocarcinoma in stages T1N0M0 and T2N0M0 from hepatic hypovascular nodules using dynamic contrast-enhanced MRI10.1038/s41598-017-08634-22045-2322https://doaj.org/article/190c8e96e1a7404c896b52a2499686e22017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08634-2https://doaj.org/toc/2045-2322Abstract Because cholangiocarcinoma shows no specific clinical signs or symptoms and presents with non-specific biological and tumor markers in the early stages, MRI findings often lack typical features before this lesion becomes symptomatic and might be mistaken for other liver lesions. An evaluation of relevant radiological findings in nodular cholangiocarcinoma (≤3 cm) in stages T1N0M0 and T2N0M0 is urgently needed. In our study, we compared two groups of liver hypovascular nodules and found that a distinct margin and enhanced area/nodule size >2/3 in the delayed phase were more frequently observed in cholangiocarcinoma cases than in metastatic nodule cases in which markedly high signal intensity on T2WI was common (p < 0.05). The results also revealed that in the both the portal and delayed phases, an enhanced area/nodule size >2/3 favored cholangiocarcinoma, whereas the presence of regional markedly higher SI on T2WI favored benign nodules. Furthermore, signs of peripheral washout in the delayed phase only appeared in cholangiocarcinoma cases.Shihong LiHaizhen QianYu PengHuihui JiaGuangwu LinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shihong Li Haizhen Qian Yu Peng Huihui Jia Guangwu Lin Differentiating peripheral cholangiocarcinoma in stages T1N0M0 and T2N0M0 from hepatic hypovascular nodules using dynamic contrast-enhanced MRI
description	Abstract Because cholangiocarcinoma shows no specific clinical signs or symptoms and presents with non-specific biological and tumor markers in the early stages, MRI findings often lack typical features before this lesion becomes symptomatic and might be mistaken for other liver lesions. An evaluation of relevant radiological findings in nodular cholangiocarcinoma (≤3 cm) in stages T1N0M0 and T2N0M0 is urgently needed. In our study, we compared two groups of liver hypovascular nodules and found that a distinct margin and enhanced area/nodule size >2/3 in the delayed phase were more frequently observed in cholangiocarcinoma cases than in metastatic nodule cases in which markedly high signal intensity on T2WI was common (p < 0.05). The results also revealed that in the both the portal and delayed phases, an enhanced area/nodule size >2/3 favored cholangiocarcinoma, whereas the presence of regional markedly higher SI on T2WI favored benign nodules. Furthermore, signs of peripheral washout in the delayed phase only appeared in cholangiocarcinoma cases.
format	article
author	Shihong Li Haizhen Qian Yu Peng Huihui Jia Guangwu Lin
author_facet	Shihong Li Haizhen Qian Yu Peng Huihui Jia Guangwu Lin
author_sort	Shihong Li
title	Differentiating peripheral cholangiocarcinoma in stages T1N0M0 and T2N0M0 from hepatic hypovascular nodules using dynamic contrast-enhanced MRI
title_short	Differentiating peripheral cholangiocarcinoma in stages T1N0M0 and T2N0M0 from hepatic hypovascular nodules using dynamic contrast-enhanced MRI
title_full	Differentiating peripheral cholangiocarcinoma in stages T1N0M0 and T2N0M0 from hepatic hypovascular nodules using dynamic contrast-enhanced MRI
title_fullStr	Differentiating peripheral cholangiocarcinoma in stages T1N0M0 and T2N0M0 from hepatic hypovascular nodules using dynamic contrast-enhanced MRI
title_full_unstemmed	Differentiating peripheral cholangiocarcinoma in stages T1N0M0 and T2N0M0 from hepatic hypovascular nodules using dynamic contrast-enhanced MRI
title_sort	differentiating peripheral cholangiocarcinoma in stages t1n0m0 and t2n0m0 from hepatic hypovascular nodules using dynamic contrast-enhanced mri
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/190c8e96e1a7404c896b52a2499686e2
work_keys_str_mv	AT shihongli differentiatingperipheralcholangiocarcinomainstagest1n0m0andt2n0m0fromhepatichypovascularnodulesusingdynamiccontrastenhancedmri AT haizhenqian differentiatingperipheralcholangiocarcinomainstagest1n0m0andt2n0m0fromhepatichypovascularnodulesusingdynamiccontrastenhancedmri AT yupeng differentiatingperipheralcholangiocarcinomainstagest1n0m0andt2n0m0fromhepatichypovascularnodulesusingdynamiccontrastenhancedmri AT huihuijia differentiatingperipheralcholangiocarcinomainstagest1n0m0andt2n0m0fromhepatichypovascularnodulesusingdynamiccontrastenhancedmri AT guangwulin differentiatingperipheralcholangiocarcinomainstagest1n0m0andt2n0m0fromhepatichypovascularnodulesusingdynamiccontrastenhancedmri
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Differentiating peripheral cholangiocarcinoma in stages T1N0M0 and T2N0M0 from hepatic hypovascular nodules using dynamic contrast-enhanced MRI

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