The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma

Progression from asymptomatic smoldering multiple myeloma (SMM) to symptomatic Multiple Myeloma occurs at different rates in different patients. Here, the authors report fewer NRAS and FAM46C mutations and adverse translocations in SMM compared to MM, while KRAS mutations are associated with a short...

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Autores principales:	Eileen M. Boyle, Shayu Deshpande, Ruslana Tytarenko, Cody Ashby, Yan Wang, Michael A. Bauer, Sarah K. Johnson, Christopher P. Wardell, Sharmilan Thanendrarajan, Maurizio Zangari, Thierry Facon, Charles Dumontet, Bart Barlogie, Arnaldo Arbini, Even H. Rustad, Francesco Maura, Ola Landgren, Fenghuang Zhan, Frits van Rhee, Carolina Schinke, Faith E. Davies, Gareth J. Morgan, Brian A. Walker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/190cc8a591d94b4a813749741597a52e
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spelling	oai:doaj.org-article:190cc8a591d94b4a813749741597a52e2021-12-02T14:01:26ZThe molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma10.1038/s41467-020-20524-22041-1723https://doaj.org/article/190cc8a591d94b4a813749741597a52e2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20524-2https://doaj.org/toc/2041-1723Progression from asymptomatic smoldering multiple myeloma (SMM) to symptomatic Multiple Myeloma occurs at different rates in different patients. Here, the authors report fewer NRAS and FAM46C mutations and adverse translocations in SMM compared to MM, while KRAS mutations are associated with a shorter time to progression.Eileen M. BoyleShayu DeshpandeRuslana TytarenkoCody AshbyYan WangMichael A. BauerSarah K. JohnsonChristopher P. WardellSharmilan ThanendrarajanMaurizio ZangariThierry FaconCharles DumontetBart BarlogieArnaldo ArbiniEven H. RustadFrancesco MauraOla LandgrenFenghuang ZhanFrits van RheeCarolina SchinkeFaith E. DaviesGareth J. MorganBrian A. WalkerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eileen M. Boyle Shayu Deshpande Ruslana Tytarenko Cody Ashby Yan Wang Michael A. Bauer Sarah K. Johnson Christopher P. Wardell Sharmilan Thanendrarajan Maurizio Zangari Thierry Facon Charles Dumontet Bart Barlogie Arnaldo Arbini Even H. Rustad Francesco Maura Ola Landgren Fenghuang Zhan Frits van Rhee Carolina Schinke Faith E. Davies Gareth J. Morgan Brian A. Walker The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma
description	Progression from asymptomatic smoldering multiple myeloma (SMM) to symptomatic Multiple Myeloma occurs at different rates in different patients. Here, the authors report fewer NRAS and FAM46C mutations and adverse translocations in SMM compared to MM, while KRAS mutations are associated with a shorter time to progression.
format	article
author	Eileen M. Boyle Shayu Deshpande Ruslana Tytarenko Cody Ashby Yan Wang Michael A. Bauer Sarah K. Johnson Christopher P. Wardell Sharmilan Thanendrarajan Maurizio Zangari Thierry Facon Charles Dumontet Bart Barlogie Arnaldo Arbini Even H. Rustad Francesco Maura Ola Landgren Fenghuang Zhan Frits van Rhee Carolina Schinke Faith E. Davies Gareth J. Morgan Brian A. Walker
author_facet	Eileen M. Boyle Shayu Deshpande Ruslana Tytarenko Cody Ashby Yan Wang Michael A. Bauer Sarah K. Johnson Christopher P. Wardell Sharmilan Thanendrarajan Maurizio Zangari Thierry Facon Charles Dumontet Bart Barlogie Arnaldo Arbini Even H. Rustad Francesco Maura Ola Landgren Fenghuang Zhan Frits van Rhee Carolina Schinke Faith E. Davies Gareth J. Morgan Brian A. Walker
author_sort	Eileen M. Boyle
title	The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma
title_short	The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma
title_full	The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma
title_fullStr	The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma
title_full_unstemmed	The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma
title_sort	molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/190cc8a591d94b4a813749741597a52e
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The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma

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