IMMUNOLOGICAL AND GENETIC CHANGES AS PREDICTORS IN THE LOSS OF PREGNANCY IN THE FORMATION OF RETROCHORIAL HEMATOMA IN THE FIRST TRIMESTER

Background. Pregnancy with a retrochorial hematoma in a third of cases ends prematurely. Detection of early markers of pregnancy loss is extremely necessary for the prevention and therapy of miscarriage.Aims. The aim of the study is development and pathogenetically substantiation a new diagnostic al...

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Autores principales:	M. V. Utrobin, S. Yu. Yuryev
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2018
Materias:	retrochorial hematoma autoantibodies miscarriage thrombophilia autoimmune thyroiditis Science Q
Acceso en línea:	https://doaj.org/article/190dd65b7ff34099bda132b663210c19
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spelling	oai:doaj.org-article:190dd65b7ff34099bda132b663210c192021-11-23T06:14:41ZIMMUNOLOGICAL AND GENETIC CHANGES AS PREDICTORS IN THE LOSS OF PREGNANCY IN THE FORMATION OF RETROCHORIAL HEMATOMA IN THE FIRST TRIMESTER2541-94202587-959610.29413/ABS.2018-3.5.1https://doaj.org/article/190dd65b7ff34099bda132b663210c192018-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/700https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Background. Pregnancy with a retrochorial hematoma in a third of cases ends prematurely. Detection of early markers of pregnancy loss is extremely necessary for the prevention and therapy of miscarriage.Aims. The aim of the study is development and pathogenetically substantiation a new diagnostic algorithm in the formation of retrochorial hematoma in the first trimester of pregnancy.Materials and methods. A prospective study of women of reproductive age with retrochorial hematoma applied at the gestational age of 6–12 weeks was performed. A study was made of polymorphic variants of genes of hemostasis system; the folate cycle by polymerase chain reaction. The level of embryotropic antibodies was determined by the ELI-P-Complex-12 system test. The course of pregnancy and delivery was monitored.Results. The study involved 113 women. There was no correlation between the isolated carrier of polymorphisms and an increased risk of pregnancy loss (p ˃ 0.05). Polymorphic variants of genes of hemostasis system; the folate cycle in combination with an increase in the level of rheumatoid factor or autoantibodies to thyroglobulin have a relationship with the risk of miscarriage (р ˂ 0.05).Conclusion. Polymorphic variants of genes of hemostasis system; the folate cycle in combination with an increase in the level of rheumatoid factor or autoantibodies to thyroglobulin are predictors of an unfavorable outcome of pregnancy. Therefore; the definition of these markers can be used for individualization of the survey; treatment at the precognitive stage and during pregnancy.M. V. UtrobinS. Yu. YuryevScientific Сentre for Family Health and Human Reproduction Problemsarticleretrochorial hematomaautoantibodiesmiscarriagethrombophiliaautoimmune thyroiditisScienceQRUActa Biomedica Scientifica, Vol 3, Iss 5, Pp 9-15 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	retrochorial hematoma autoantibodies miscarriage thrombophilia autoimmune thyroiditis Science Q
spellingShingle	retrochorial hematoma autoantibodies miscarriage thrombophilia autoimmune thyroiditis Science Q M. V. Utrobin S. Yu. Yuryev IMMUNOLOGICAL AND GENETIC CHANGES AS PREDICTORS IN THE LOSS OF PREGNANCY IN THE FORMATION OF RETROCHORIAL HEMATOMA IN THE FIRST TRIMESTER
description	Background. Pregnancy with a retrochorial hematoma in a third of cases ends prematurely. Detection of early markers of pregnancy loss is extremely necessary for the prevention and therapy of miscarriage.Aims. The aim of the study is development and pathogenetically substantiation a new diagnostic algorithm in the formation of retrochorial hematoma in the first trimester of pregnancy.Materials and methods. A prospective study of women of reproductive age with retrochorial hematoma applied at the gestational age of 6–12 weeks was performed. A study was made of polymorphic variants of genes of hemostasis system; the folate cycle by polymerase chain reaction. The level of embryotropic antibodies was determined by the ELI-P-Complex-12 system test. The course of pregnancy and delivery was monitored.Results. The study involved 113 women. There was no correlation between the isolated carrier of polymorphisms and an increased risk of pregnancy loss (p ˃ 0.05). Polymorphic variants of genes of hemostasis system; the folate cycle in combination with an increase in the level of rheumatoid factor or autoantibodies to thyroglobulin have a relationship with the risk of miscarriage (р ˂ 0.05).Conclusion. Polymorphic variants of genes of hemostasis system; the folate cycle in combination with an increase in the level of rheumatoid factor or autoantibodies to thyroglobulin are predictors of an unfavorable outcome of pregnancy. Therefore; the definition of these markers can be used for individualization of the survey; treatment at the precognitive stage and during pregnancy.
format	article
author	M. V. Utrobin S. Yu. Yuryev
author_facet	M. V. Utrobin S. Yu. Yuryev
author_sort	M. V. Utrobin
title	IMMUNOLOGICAL AND GENETIC CHANGES AS PREDICTORS IN THE LOSS OF PREGNANCY IN THE FORMATION OF RETROCHORIAL HEMATOMA IN THE FIRST TRIMESTER
title_short	IMMUNOLOGICAL AND GENETIC CHANGES AS PREDICTORS IN THE LOSS OF PREGNANCY IN THE FORMATION OF RETROCHORIAL HEMATOMA IN THE FIRST TRIMESTER
title_full	IMMUNOLOGICAL AND GENETIC CHANGES AS PREDICTORS IN THE LOSS OF PREGNANCY IN THE FORMATION OF RETROCHORIAL HEMATOMA IN THE FIRST TRIMESTER
title_fullStr	IMMUNOLOGICAL AND GENETIC CHANGES AS PREDICTORS IN THE LOSS OF PREGNANCY IN THE FORMATION OF RETROCHORIAL HEMATOMA IN THE FIRST TRIMESTER
title_full_unstemmed	IMMUNOLOGICAL AND GENETIC CHANGES AS PREDICTORS IN THE LOSS OF PREGNANCY IN THE FORMATION OF RETROCHORIAL HEMATOMA IN THE FIRST TRIMESTER
title_sort	immunological and genetic changes as predictors in the loss of pregnancy in the formation of retrochorial hematoma in the first trimester
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2018
url	https://doaj.org/article/190dd65b7ff34099bda132b663210c19
work_keys_str_mv	AT mvutrobin immunologicalandgeneticchangesaspredictorsinthelossofpregnancyintheformationofretrochorialhematomainthefirsttrimester AT syuyuryev immunologicalandgeneticchangesaspredictorsinthelossofpregnancyintheformationofretrochorialhematomainthefirsttrimester
_version_	1718416928515555328

IMMUNOLOGICAL AND GENETIC CHANGES AS PREDICTORS IN THE LOSS OF PREGNANCY IN THE FORMATION OF RETROCHORIAL HEMATOMA IN THE FIRST TRIMESTER

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