Statins and the risk of lung cancer: a meta-analysis.

<h4>Purpose</h4>Several epidemiologic studies have evaluated the association between statins and lung cancer risk, whereas randomized controlled trials (RCTs) on cardiovascular outcomes provide relevant data as a secondary end point. We conducted a meta-analysis of all relevant studies t...

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Autores principales:	Min Tan, Xiaolian Song, Guoliang Zhang, Aimei Peng, Xuan Li, Ming Li, Yang Liu, Changhui Wang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/190f4e2b829740399c4923c79ac9763c
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spelling	oai:doaj.org-article:190f4e2b829740399c4923c79ac9763c2021-11-18T07:55:33ZStatins and the risk of lung cancer: a meta-analysis.1932-620310.1371/journal.pone.0057349https://doaj.org/article/190f4e2b829740399c4923c79ac9763c2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23468972/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Purpose</h4>Several epidemiologic studies have evaluated the association between statins and lung cancer risk, whereas randomized controlled trials (RCTs) on cardiovascular outcomes provide relevant data as a secondary end point. We conducted a meta-analysis of all relevant studies to examine this association.<h4>Methods</h4>A systematic literature search up to March 2012 was performed in PubMed database. Study-specific risk estimates were pooled using a random-effects model.<h4>Results</h4>Nineteen studies (5 RCTs and 14 observational studies) involving 38,013 lung cancer cases contributed to the analysis. They were grouped on the basis of study design, and separate meta-analyses were conducted. There was no evidence of an association between statin use and risk of lung cancer either among RCTs (relative risk [RR] 0.91, 95% confidence interval [CI] 0.76-1.09), among cohort studies (RR 0.94, 95% CI 0.82-1.07), or among case-control studies (RR 0.82, 95% CI 0.57-1.16). Low evidence of publication bias was found. However, statistically significant heterogeneity was found among cohort studies and among case-control studies. After excluding the studies contributing most to the heterogeneity, summary estimates were essentially unchanged.<h4>Conclusion</h4>The results of our meta-analysis suggest that there is no association between statin use and the risk of lung cancer.Min TanXiaolian SongGuoliang ZhangAimei PengXuan LiMing LiYang LiuChanghui WangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 2, p e57349 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Min Tan Xiaolian Song Guoliang Zhang Aimei Peng Xuan Li Ming Li Yang Liu Changhui Wang Statins and the risk of lung cancer: a meta-analysis.
description	<h4>Purpose</h4>Several epidemiologic studies have evaluated the association between statins and lung cancer risk, whereas randomized controlled trials (RCTs) on cardiovascular outcomes provide relevant data as a secondary end point. We conducted a meta-analysis of all relevant studies to examine this association.<h4>Methods</h4>A systematic literature search up to March 2012 was performed in PubMed database. Study-specific risk estimates were pooled using a random-effects model.<h4>Results</h4>Nineteen studies (5 RCTs and 14 observational studies) involving 38,013 lung cancer cases contributed to the analysis. They were grouped on the basis of study design, and separate meta-analyses were conducted. There was no evidence of an association between statin use and risk of lung cancer either among RCTs (relative risk [RR] 0.91, 95% confidence interval [CI] 0.76-1.09), among cohort studies (RR 0.94, 95% CI 0.82-1.07), or among case-control studies (RR 0.82, 95% CI 0.57-1.16). Low evidence of publication bias was found. However, statistically significant heterogeneity was found among cohort studies and among case-control studies. After excluding the studies contributing most to the heterogeneity, summary estimates were essentially unchanged.<h4>Conclusion</h4>The results of our meta-analysis suggest that there is no association between statin use and the risk of lung cancer.
format	article
author	Min Tan Xiaolian Song Guoliang Zhang Aimei Peng Xuan Li Ming Li Yang Liu Changhui Wang
author_facet	Min Tan Xiaolian Song Guoliang Zhang Aimei Peng Xuan Li Ming Li Yang Liu Changhui Wang
author_sort	Min Tan
title	Statins and the risk of lung cancer: a meta-analysis.
title_short	Statins and the risk of lung cancer: a meta-analysis.
title_full	Statins and the risk of lung cancer: a meta-analysis.
title_fullStr	Statins and the risk of lung cancer: a meta-analysis.
title_full_unstemmed	Statins and the risk of lung cancer: a meta-analysis.
title_sort	statins and the risk of lung cancer: a meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/190f4e2b829740399c4923c79ac9763c
work_keys_str_mv	AT mintan statinsandtheriskoflungcancerametaanalysis AT xiaoliansong statinsandtheriskoflungcancerametaanalysis AT guoliangzhang statinsandtheriskoflungcancerametaanalysis AT aimeipeng statinsandtheriskoflungcancerametaanalysis AT xuanli statinsandtheriskoflungcancerametaanalysis AT mingli statinsandtheriskoflungcancerametaanalysis AT yangliu statinsandtheriskoflungcancerametaanalysis AT changhuiwang statinsandtheriskoflungcancerametaanalysis
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Statins and the risk of lung cancer: a meta-analysis.

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