A conserved neuropeptide system links head and body motor circuits to enable adaptive behavior

Neuromodulators promote adaptive behaviors that are often complex and involve concerted activity changes across circuits that are often not physically connected. It is not well understood how neuromodulatory systems accomplish these tasks. Here, we show that the Caenorhabditis elegans NLP-12 neurope...

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Autores principales:	Shankar Ramachandran, Navonil Banerjee, Raja Bhattacharya, Michele L Lemons, Jeremy Florman, Christopher M Lambert, Denis Touroutine, Kellianne Alexander, Liliane Schoofs, Mark J Alkema, Isabel Beets, Michael M Francis
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	neuropeptide cholecystokinin neural circuits C. elegans G protein-coupled receptor local search Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/19100ae39dc84f1fa80aeca26480415c
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spelling	oai:doaj.org-article:19100ae39dc84f1fa80aeca26480415c2021-11-26T13:28:09ZA conserved neuropeptide system links head and body motor circuits to enable adaptive behavior10.7554/eLife.717472050-084Xe71747https://doaj.org/article/19100ae39dc84f1fa80aeca26480415c2021-11-01T00:00:00Zhttps://elifesciences.org/articles/71747https://doaj.org/toc/2050-084XNeuromodulators promote adaptive behaviors that are often complex and involve concerted activity changes across circuits that are often not physically connected. It is not well understood how neuromodulatory systems accomplish these tasks. Here, we show that the Caenorhabditis elegans NLP-12 neuropeptide system shapes responses to food availability by modulating the activity of head and body wall motor neurons through alternate G-protein coupled receptor (GPCR) targets, CKR-1 and CKR-2. We show ckr-2 deletion reduces body bend depth during movement under basal conditions. We demonstrate CKR-1 is a functional NLP-12 receptor and define its expression in the nervous system. In contrast to basal locomotion, biased CKR-1 GPCR stimulation of head motor neurons promotes turning during local searching. Deletion of ckr-1 reduces head neuron activity and diminishes turning while specific ckr-1 overexpression or head neuron activation promote turning. Thus, our studies suggest locomotor responses to changing food availability are regulated through conditional NLP-12 stimulation of head or body wall motor circuits.Shankar RamachandranNavonil BanerjeeRaja BhattacharyaMichele L LemonsJeremy FlormanChristopher M LambertDenis TouroutineKellianne AlexanderLiliane SchoofsMark J AlkemaIsabel BeetsMichael M FranciseLife Sciences Publications Ltdarticleneuropeptidecholecystokininneural circuitsC. elegansG protein-coupled receptorlocal searchMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neuropeptide cholecystokinin neural circuits C. elegans G protein-coupled receptor local search Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	neuropeptide cholecystokinin neural circuits C. elegans G protein-coupled receptor local search Medicine R Science Q Biology (General) QH301-705.5 Shankar Ramachandran Navonil Banerjee Raja Bhattacharya Michele L Lemons Jeremy Florman Christopher M Lambert Denis Touroutine Kellianne Alexander Liliane Schoofs Mark J Alkema Isabel Beets Michael M Francis A conserved neuropeptide system links head and body motor circuits to enable adaptive behavior
description	Neuromodulators promote adaptive behaviors that are often complex and involve concerted activity changes across circuits that are often not physically connected. It is not well understood how neuromodulatory systems accomplish these tasks. Here, we show that the Caenorhabditis elegans NLP-12 neuropeptide system shapes responses to food availability by modulating the activity of head and body wall motor neurons through alternate G-protein coupled receptor (GPCR) targets, CKR-1 and CKR-2. We show ckr-2 deletion reduces body bend depth during movement under basal conditions. We demonstrate CKR-1 is a functional NLP-12 receptor and define its expression in the nervous system. In contrast to basal locomotion, biased CKR-1 GPCR stimulation of head motor neurons promotes turning during local searching. Deletion of ckr-1 reduces head neuron activity and diminishes turning while specific ckr-1 overexpression or head neuron activation promote turning. Thus, our studies suggest locomotor responses to changing food availability are regulated through conditional NLP-12 stimulation of head or body wall motor circuits.
format	article
author	Shankar Ramachandran Navonil Banerjee Raja Bhattacharya Michele L Lemons Jeremy Florman Christopher M Lambert Denis Touroutine Kellianne Alexander Liliane Schoofs Mark J Alkema Isabel Beets Michael M Francis
author_facet	Shankar Ramachandran Navonil Banerjee Raja Bhattacharya Michele L Lemons Jeremy Florman Christopher M Lambert Denis Touroutine Kellianne Alexander Liliane Schoofs Mark J Alkema Isabel Beets Michael M Francis
author_sort	Shankar Ramachandran
title	A conserved neuropeptide system links head and body motor circuits to enable adaptive behavior
title_short	A conserved neuropeptide system links head and body motor circuits to enable adaptive behavior
title_full	A conserved neuropeptide system links head and body motor circuits to enable adaptive behavior
title_fullStr	A conserved neuropeptide system links head and body motor circuits to enable adaptive behavior
title_full_unstemmed	A conserved neuropeptide system links head and body motor circuits to enable adaptive behavior
title_sort	conserved neuropeptide system links head and body motor circuits to enable adaptive behavior
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/19100ae39dc84f1fa80aeca26480415c
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A conserved neuropeptide system links head and body motor circuits to enable adaptive behavior

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