A chemo-enzymatic oxidation cascade to activate C–H bonds with in situ generated H2O2

Continuous low-level supply or in situ generation of hydrogen peroxide (H2O2) is essential for the stability of unspecific peroxygenases. Here, the authors demonstrate that AuPd / TiO2 can generate sufficient H2O2 for the engineered unspecific heme-thiolate peroxygenase PaDa-I to oxidise a range of...

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Autores principales:	Simon J. Freakley, Svenja Kochius, Jacqueline van Marwijk, Caryn Fenner, Richard J. Lewis, Kai Baldenius, Sarel S. Marais, Diederik J. Opperman, Susan T. L. Harrison, Miguel Alcalde, Martha S. Smit, Graham J. Hutchings
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/191eddc66cb84147bad26f6e594b73cf
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spelling	oai:doaj.org-article:191eddc66cb84147bad26f6e594b73cf2021-12-02T16:58:28ZA chemo-enzymatic oxidation cascade to activate C–H bonds with in situ generated H2O210.1038/s41467-019-12120-w2041-1723https://doaj.org/article/191eddc66cb84147bad26f6e594b73cf2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12120-whttps://doaj.org/toc/2041-1723Continuous low-level supply or in situ generation of hydrogen peroxide (H2O2) is essential for the stability of unspecific peroxygenases. Here, the authors demonstrate that AuPd / TiO2 can generate sufficient H2O2 for the engineered unspecific heme-thiolate peroxygenase PaDa-I to oxidise a range of C-H bonds.Simon J. FreakleySvenja KochiusJacqueline van MarwijkCaryn FennerRichard J. LewisKai BaldeniusSarel S. MaraisDiederik J. OppermanSusan T. L. HarrisonMiguel AlcaldeMartha S. SmitGraham J. HutchingsNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Simon J. Freakley Svenja Kochius Jacqueline van Marwijk Caryn Fenner Richard J. Lewis Kai Baldenius Sarel S. Marais Diederik J. Opperman Susan T. L. Harrison Miguel Alcalde Martha S. Smit Graham J. Hutchings A chemo-enzymatic oxidation cascade to activate C–H bonds with in situ generated H2O2
description	Continuous low-level supply or in situ generation of hydrogen peroxide (H2O2) is essential for the stability of unspecific peroxygenases. Here, the authors demonstrate that AuPd / TiO2 can generate sufficient H2O2 for the engineered unspecific heme-thiolate peroxygenase PaDa-I to oxidise a range of C-H bonds.
format	article
author	Simon J. Freakley Svenja Kochius Jacqueline van Marwijk Caryn Fenner Richard J. Lewis Kai Baldenius Sarel S. Marais Diederik J. Opperman Susan T. L. Harrison Miguel Alcalde Martha S. Smit Graham J. Hutchings
author_facet	Simon J. Freakley Svenja Kochius Jacqueline van Marwijk Caryn Fenner Richard J. Lewis Kai Baldenius Sarel S. Marais Diederik J. Opperman Susan T. L. Harrison Miguel Alcalde Martha S. Smit Graham J. Hutchings
author_sort	Simon J. Freakley
title	A chemo-enzymatic oxidation cascade to activate C–H bonds with in situ generated H2O2
title_short	A chemo-enzymatic oxidation cascade to activate C–H bonds with in situ generated H2O2
title_full	A chemo-enzymatic oxidation cascade to activate C–H bonds with in situ generated H2O2
title_fullStr	A chemo-enzymatic oxidation cascade to activate C–H bonds with in situ generated H2O2
title_full_unstemmed	A chemo-enzymatic oxidation cascade to activate C–H bonds with in situ generated H2O2
title_sort	chemo-enzymatic oxidation cascade to activate c–h bonds with in situ generated h2o2
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/191eddc66cb84147bad26f6e594b73cf
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A chemo-enzymatic oxidation cascade to activate C–H bonds with in situ generated H2O2

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