Association between short-term heart rate variability and blood coagulation in patients with breast cancer

Abstract The purpose of this study was to investigate the relationship between heart rate variability (HRV), a non-invasive tool for evaluating autonomic function, and routine coagulation indices (RCIs) in patients with breast cancer (BC). Forty-six BC patients were enrolled in this study. Blood bio...

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Autores principales:	Lingling Wang, Jingfeng Wang, Peng Li, Xiangzhi Wang, Shuang Wu, Bo Shi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1920d1f51b874dce9a7935b74e561f4b
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spelling	oai:doaj.org-article:1920d1f51b874dce9a7935b74e561f4b2021-12-02T18:47:00ZAssociation between short-term heart rate variability and blood coagulation in patients with breast cancer10.1038/s41598-021-94931-w2045-2322https://doaj.org/article/1920d1f51b874dce9a7935b74e561f4b2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94931-whttps://doaj.org/toc/2045-2322Abstract The purpose of this study was to investigate the relationship between heart rate variability (HRV), a non-invasive tool for evaluating autonomic function, and routine coagulation indices (RCIs) in patients with breast cancer (BC). Forty-six BC patients were enrolled in this study. Blood biochemistry tests were performed to extract RCIs, including prothrombin time (PT), activated partial thromboplastin time (APTT), and thrombin time (TT). Five-minute electrocardiograms were collected for analysis of HRV parameters (SDNN, RMSSD, LF, HF, LF n.u., HF n.u., LF/HF). Multiple linear regression models examined the relationship of HRV parameters with RCIs. RMSSD, LF n.u., HF n.u., LF/HF were significantly associated with PT. Specifically, the value of PT increased by 0.192 ± 0.091 or 0.231 ± 0.088 s, respectively for each 1 standard deviation (SD) increase in RMSSD or HF n.u.; it increased by 0.230 ± 0.088 or 0.215 ± 0.088 s, respectively for each 1 − SD decrease in LF n.u. or ln (LF/HF) (all P < 0.05). RMSSD was significantly associated with APTT, i.e., the value of APTT increased by 1.032 ± 0.470 s for each 1 − SD increase in RMSSD (P < 0.05). HRV parameters were associated with RCIs in patients with BC. These observations suggest that the autonomic nervous system and coagulation indices in BC patients are linked, potentially explaining the reason that they are both associated with the prognosis.Lingling WangJingfeng WangPeng LiXiangzhi WangShuang WuBo ShiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lingling Wang Jingfeng Wang Peng Li Xiangzhi Wang Shuang Wu Bo Shi Association between short-term heart rate variability and blood coagulation in patients with breast cancer
description	Abstract The purpose of this study was to investigate the relationship between heart rate variability (HRV), a non-invasive tool for evaluating autonomic function, and routine coagulation indices (RCIs) in patients with breast cancer (BC). Forty-six BC patients were enrolled in this study. Blood biochemistry tests were performed to extract RCIs, including prothrombin time (PT), activated partial thromboplastin time (APTT), and thrombin time (TT). Five-minute electrocardiograms were collected for analysis of HRV parameters (SDNN, RMSSD, LF, HF, LF n.u., HF n.u., LF/HF). Multiple linear regression models examined the relationship of HRV parameters with RCIs. RMSSD, LF n.u., HF n.u., LF/HF were significantly associated with PT. Specifically, the value of PT increased by 0.192 ± 0.091 or 0.231 ± 0.088 s, respectively for each 1 standard deviation (SD) increase in RMSSD or HF n.u.; it increased by 0.230 ± 0.088 or 0.215 ± 0.088 s, respectively for each 1 − SD decrease in LF n.u. or ln (LF/HF) (all P < 0.05). RMSSD was significantly associated with APTT, i.e., the value of APTT increased by 1.032 ± 0.470 s for each 1 − SD increase in RMSSD (P < 0.05). HRV parameters were associated with RCIs in patients with BC. These observations suggest that the autonomic nervous system and coagulation indices in BC patients are linked, potentially explaining the reason that they are both associated with the prognosis.
format	article
author	Lingling Wang Jingfeng Wang Peng Li Xiangzhi Wang Shuang Wu Bo Shi
author_facet	Lingling Wang Jingfeng Wang Peng Li Xiangzhi Wang Shuang Wu Bo Shi
author_sort	Lingling Wang
title	Association between short-term heart rate variability and blood coagulation in patients with breast cancer
title_short	Association between short-term heart rate variability and blood coagulation in patients with breast cancer
title_full	Association between short-term heart rate variability and blood coagulation in patients with breast cancer
title_fullStr	Association between short-term heart rate variability and blood coagulation in patients with breast cancer
title_full_unstemmed	Association between short-term heart rate variability and blood coagulation in patients with breast cancer
title_sort	association between short-term heart rate variability and blood coagulation in patients with breast cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1920d1f51b874dce9a7935b74e561f4b
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Association between short-term heart rate variability and blood coagulation in patients with breast cancer

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