Glomerular Filtration Dysfunction is Associated with Cardiac Adverse Remodeling in Menopausal Diabetic Chinese Women

Xing Song,1 Gang Li,1 Yuqi Zhu,1 Jari A Laukkanen2– 4 1Division of Cardiology, Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Institute of Public Health and Clinical Nutrition, University of Eastern...

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Autores principales:	Song X, Li G, Zhu Y, Laukkanen JA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	glomerular filtration rate type 2 diabetes mellitus cardiac remodeling menopausal women aging Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/1923cb3990df43528c61581bd422d034
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spelling	oai:doaj.org-article:1923cb3990df43528c61581bd422d0342021-12-02T14:39:09ZGlomerular Filtration Dysfunction is Associated with Cardiac Adverse Remodeling in Menopausal Diabetic Chinese Women1178-1998https://doaj.org/article/1923cb3990df43528c61581bd422d0342021-04-01T00:00:00Zhttps://www.dovepress.com/glomerular-filtration-dysfunction-is-associated-with-cardiac-adverse-r-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Xing Song,1 Gang Li,1 Yuqi Zhu,1 Jari A Laukkanen2– 4 1Division of Cardiology, Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; 3Institute of Clinical Medicine, Department of Medicine, University of Eastern Finland, Kuopio, Finland; 4Central Finland Health Care District, Department of Medicine, Jyväskylä, FinlandCorrespondence: Gang LiDivision of Cardiology, Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing, 400016, People’s Republic of ChinaTel +86 23 89011518Fax +86 23 68811487Email ganglicqmu@126.comBackground: Previous studies have showed that nephropathy was associated with cardiac structural changes and dysfunction among diabetic adults. However, information on the association of glomerular filtration dysfunction with the cardiac adverse remodeling is still limited in menopausal diabetic women. Therefore, we investigated whether impaired glomerular filtration function is associated with the cardiac adverse remodeling in menopausal Chinese women with type 2 diabetes mellitus (DM).Methods: A total of 1231 hospitalized menopausal Chinese women with type 2 DM were collected retrospectively. The cross-sectional data of echocardiography were compared among estimated glomerular filtration rate (eGFR) categorized groups.Results: In menopausal diabetic women, moderate to severe glomerular filtration dysfunction (eGFR < 60 mL/min per 1.73m2) was found to be associated with enlarged left-side atrioventricular chambers, increased ventricular wall thickness, decreased cardiac function and dilated right ventricle (All P < 0.05).Conclusion: Glomerular filtration dysfunction is associated with cardiac adverse structural remodeling and dysfunction in menopausal Chinese women with type 2 DM.Keywords: glomerular filtration rate, type 2 diabetes mellitus, cardiac remodeling, menopausal women, agingSong XLi GZhu YLaukkanen JADove Medical Pressarticleglomerular filtration ratetype 2 diabetes mellituscardiac remodelingmenopausal womenagingGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 16, Pp 603-609 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	glomerular filtration rate type 2 diabetes mellitus cardiac remodeling menopausal women aging Geriatrics RC952-954.6
spellingShingle	glomerular filtration rate type 2 diabetes mellitus cardiac remodeling menopausal women aging Geriatrics RC952-954.6 Song X Li G Zhu Y Laukkanen JA Glomerular Filtration Dysfunction is Associated with Cardiac Adverse Remodeling in Menopausal Diabetic Chinese Women
description	Xing Song,1 Gang Li,1 Yuqi Zhu,1 Jari A Laukkanen2– 4 1Division of Cardiology, Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; 3Institute of Clinical Medicine, Department of Medicine, University of Eastern Finland, Kuopio, Finland; 4Central Finland Health Care District, Department of Medicine, Jyväskylä, FinlandCorrespondence: Gang LiDivision of Cardiology, Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing, 400016, People’s Republic of ChinaTel +86 23 89011518Fax +86 23 68811487Email ganglicqmu@126.comBackground: Previous studies have showed that nephropathy was associated with cardiac structural changes and dysfunction among diabetic adults. However, information on the association of glomerular filtration dysfunction with the cardiac adverse remodeling is still limited in menopausal diabetic women. Therefore, we investigated whether impaired glomerular filtration function is associated with the cardiac adverse remodeling in menopausal Chinese women with type 2 diabetes mellitus (DM).Methods: A total of 1231 hospitalized menopausal Chinese women with type 2 DM were collected retrospectively. The cross-sectional data of echocardiography were compared among estimated glomerular filtration rate (eGFR) categorized groups.Results: In menopausal diabetic women, moderate to severe glomerular filtration dysfunction (eGFR < 60 mL/min per 1.73m2) was found to be associated with enlarged left-side atrioventricular chambers, increased ventricular wall thickness, decreased cardiac function and dilated right ventricle (All P < 0.05).Conclusion: Glomerular filtration dysfunction is associated with cardiac adverse structural remodeling and dysfunction in menopausal Chinese women with type 2 DM.Keywords: glomerular filtration rate, type 2 diabetes mellitus, cardiac remodeling, menopausal women, aging
format	article
author	Song X Li G Zhu Y Laukkanen JA
author_facet	Song X Li G Zhu Y Laukkanen JA
author_sort	Song X
title	Glomerular Filtration Dysfunction is Associated with Cardiac Adverse Remodeling in Menopausal Diabetic Chinese Women
title_short	Glomerular Filtration Dysfunction is Associated with Cardiac Adverse Remodeling in Menopausal Diabetic Chinese Women
title_full	Glomerular Filtration Dysfunction is Associated with Cardiac Adverse Remodeling in Menopausal Diabetic Chinese Women
title_fullStr	Glomerular Filtration Dysfunction is Associated with Cardiac Adverse Remodeling in Menopausal Diabetic Chinese Women
title_full_unstemmed	Glomerular Filtration Dysfunction is Associated with Cardiac Adverse Remodeling in Menopausal Diabetic Chinese Women
title_sort	glomerular filtration dysfunction is associated with cardiac adverse remodeling in menopausal diabetic chinese women
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/1923cb3990df43528c61581bd422d034
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Glomerular Filtration Dysfunction is Associated with Cardiac Adverse Remodeling in Menopausal Diabetic Chinese Women

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