Evaluation of In vivo antimalarial property of Nyctanthes arbor-tristis (night jasmine) leaves

Background: Nyctanthes arbor-tristis (NAT) is an ornamental garden plant traditionally used for treating many diseases such as helminthiasis, arthritis, and malaria. Aims: The aim of this study was to validate the ethnobotanical uses of the antimalarial activity of leaves of NAT by in vivo tests. Ma...

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Autores principales:	Lopamudra Das, Ashok Kumar Panigrahi, Sashi Bhusan Biswal, Debasis Bisoi
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	iridoid glycosides malaria night jasmine nyctanthes arbor-tristis oxidative stress Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142
Acceso en línea:	https://doaj.org/article/1925b599d88e4d469d33a2b4e2295ff2
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spelling	oai:doaj.org-article:1925b599d88e4d469d33a2b4e2295ff22021-11-19T12:15:52ZEvaluation of In vivo antimalarial property of Nyctanthes arbor-tristis (night jasmine) leaves0975-740610.4103/jpbs.jpbs_167_21https://doaj.org/article/1925b599d88e4d469d33a2b4e2295ff22021-01-01T00:00:00Zhttp://www.jpbsonline.org/article.asp?issn=0975-7406;year=2021;volume=13;issue=6;spage=1088;epage=1092;aulast=Dashttps://doaj.org/toc/0975-7406Background: Nyctanthes arbor-tristis (NAT) is an ornamental garden plant traditionally used for treating many diseases such as helminthiasis, arthritis, and malaria. Aims: The aim of this study was to validate the ethnobotanical uses of the antimalarial activity of leaves of NAT by in vivo tests. Materials and Methods: Leaves of NAT were identified and authenticated and phytoconstituents of NAT were identified. The antimalarial activity of NAT was studied in in vivo for its schizonticidal activity, repository activity, and curative tests in Swiss albino mice by using Plasmodium berghei (ANKA). Statistical Analysis Used: One-way ANOVA was done for comparison of different groups followed by post hoc analysis (Tukey-Kramer multiple comparison tests). Level of significance was at P < 0.05. Results: The mean schizonticidal activity of NAT increased from 14.21 to 46.15 (P < 0.01) with doses ranging from 100 to 200 mg/kg compared to 67.29 with that of chloroquine (CQ). The repository activity with NAT doses 100–200 mg/kg increased from 12.91 to 42.85 (P < 0.01) compared to 78.79 in pyrimethamine 1.2 mg/kg/day. In Rane's test, there was chemosuppression in range of 55.50–65.02 (P < 0.01) with NAT in doses of 100–200 mg/kg compared to 74.15 with that of CQ 5 mg/kg. Conclusions: The antiplasmodial activity of NAT might be like that of artemisinin by producing oxidative stress mostly due to the iridoid glycosides. The active phytoconstituent(s) responsible may be tested individually or in combination both by in vitro and in vivo studies to identify the active chemical ingredient.Lopamudra DasAshok Kumar PanigrahiSashi Bhusan BiswalDebasis BisoiWolters Kluwer Medknow Publicationsarticleiridoid glycosidesmalarianight jasminenyctanthes arbor-tristisoxidative stressPharmacy and materia medicaRS1-441Analytical chemistryQD71-142ENJournal of Pharmacy and Bioallied Sciences, Vol 13, Iss 6, Pp 1088-1092 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	iridoid glycosides malaria night jasmine nyctanthes arbor-tristis oxidative stress Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142
spellingShingle	iridoid glycosides malaria night jasmine nyctanthes arbor-tristis oxidative stress Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142 Lopamudra Das Ashok Kumar Panigrahi Sashi Bhusan Biswal Debasis Bisoi Evaluation of In vivo antimalarial property of Nyctanthes arbor-tristis (night jasmine) leaves
description	Background: Nyctanthes arbor-tristis (NAT) is an ornamental garden plant traditionally used for treating many diseases such as helminthiasis, arthritis, and malaria. Aims: The aim of this study was to validate the ethnobotanical uses of the antimalarial activity of leaves of NAT by in vivo tests. Materials and Methods: Leaves of NAT were identified and authenticated and phytoconstituents of NAT were identified. The antimalarial activity of NAT was studied in in vivo for its schizonticidal activity, repository activity, and curative tests in Swiss albino mice by using Plasmodium berghei (ANKA). Statistical Analysis Used: One-way ANOVA was done for comparison of different groups followed by post hoc analysis (Tukey-Kramer multiple comparison tests). Level of significance was at P < 0.05. Results: The mean schizonticidal activity of NAT increased from 14.21 to 46.15 (P < 0.01) with doses ranging from 100 to 200 mg/kg compared to 67.29 with that of chloroquine (CQ). The repository activity with NAT doses 100–200 mg/kg increased from 12.91 to 42.85 (P < 0.01) compared to 78.79 in pyrimethamine 1.2 mg/kg/day. In Rane's test, there was chemosuppression in range of 55.50–65.02 (P < 0.01) with NAT in doses of 100–200 mg/kg compared to 74.15 with that of CQ 5 mg/kg. Conclusions: The antiplasmodial activity of NAT might be like that of artemisinin by producing oxidative stress mostly due to the iridoid glycosides. The active phytoconstituent(s) responsible may be tested individually or in combination both by in vitro and in vivo studies to identify the active chemical ingredient.
format	article
author	Lopamudra Das Ashok Kumar Panigrahi Sashi Bhusan Biswal Debasis Bisoi
author_facet	Lopamudra Das Ashok Kumar Panigrahi Sashi Bhusan Biswal Debasis Bisoi
author_sort	Lopamudra Das
title	Evaluation of In vivo antimalarial property of Nyctanthes arbor-tristis (night jasmine) leaves
title_short	Evaluation of In vivo antimalarial property of Nyctanthes arbor-tristis (night jasmine) leaves
title_full	Evaluation of In vivo antimalarial property of Nyctanthes arbor-tristis (night jasmine) leaves
title_fullStr	Evaluation of In vivo antimalarial property of Nyctanthes arbor-tristis (night jasmine) leaves
title_full_unstemmed	Evaluation of In vivo antimalarial property of Nyctanthes arbor-tristis (night jasmine) leaves
title_sort	evaluation of in vivo antimalarial property of nyctanthes arbor-tristis (night jasmine) leaves
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/1925b599d88e4d469d33a2b4e2295ff2
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Evaluation of In vivo antimalarial property of Nyctanthes arbor-tristis (night jasmine) leaves

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