Female rats with severe left ventricle volume overload exhibit more cardiac hypertrophy but fewer myocardial transcriptional changes than males

Abstract Aortic valve regurgitation (AR) imposes a volume overload (VO) to the left ventricle (LV). Male rats with a pathological heart overload usually progress more quickly towards heart failure than females. We examined whether a sexual dimorphism exists in the myocardial transcriptional adaptati...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Catherine Beaumont, Élisabeth Walsh-Wilkinson, Marie-Claude Drolet, Élise Roussel, Marie Arsenault, Jacques Couet
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/19273e3852134af8ad0171b0556572c3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:19273e3852134af8ad0171b0556572c3
record_format	dspace
spelling	oai:doaj.org-article:19273e3852134af8ad0171b0556572c32021-12-02T16:06:20ZFemale rats with severe left ventricle volume overload exhibit more cardiac hypertrophy but fewer myocardial transcriptional changes than males10.1038/s41598-017-00855-92045-2322https://doaj.org/article/19273e3852134af8ad0171b0556572c32017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00855-9https://doaj.org/toc/2045-2322Abstract Aortic valve regurgitation (AR) imposes a volume overload (VO) to the left ventricle (LV). Male rats with a pathological heart overload usually progress more quickly towards heart failure than females. We examined whether a sexual dimorphism exists in the myocardial transcriptional adaptations to AR. Adult Wistar male and female rats either underwent a sham operation or were induced with AR and then followed for 26 weeks. Female AR rats gained relatively more LV mass than males (75 vs. 42%). They had a similar increase in LV chamber dimensions compared to males but more wall thickening. On the other hand, fatty acid oxidation (FAO)-related LV enzyme activity was only decreased in AR males. The expression of genes encoding FAO-related enzymes was only reduced in AR males and not in females. A similar situation was observed for the expression of genes involved in mitochondrial biogenesis or function as well as for genes encoding for transcription factors implicated in the control of bioenergetics and mitochondrial function (Errα, Errγ or Pgc1α). Although females develop more LV hypertrophy from severe VO, their myocardial gene expression remains closer to normal. This could provide survival benefits for females with severe VO.Catherine BeaumontÉlisabeth Walsh-WilkinsonMarie-Claude DroletÉlise RousselMarie ArsenaultJacques CouetNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Catherine Beaumont Élisabeth Walsh-Wilkinson Marie-Claude Drolet Élise Roussel Marie Arsenault Jacques Couet Female rats with severe left ventricle volume overload exhibit more cardiac hypertrophy but fewer myocardial transcriptional changes than males
description	Abstract Aortic valve regurgitation (AR) imposes a volume overload (VO) to the left ventricle (LV). Male rats with a pathological heart overload usually progress more quickly towards heart failure than females. We examined whether a sexual dimorphism exists in the myocardial transcriptional adaptations to AR. Adult Wistar male and female rats either underwent a sham operation or were induced with AR and then followed for 26 weeks. Female AR rats gained relatively more LV mass than males (75 vs. 42%). They had a similar increase in LV chamber dimensions compared to males but more wall thickening. On the other hand, fatty acid oxidation (FAO)-related LV enzyme activity was only decreased in AR males. The expression of genes encoding FAO-related enzymes was only reduced in AR males and not in females. A similar situation was observed for the expression of genes involved in mitochondrial biogenesis or function as well as for genes encoding for transcription factors implicated in the control of bioenergetics and mitochondrial function (Errα, Errγ or Pgc1α). Although females develop more LV hypertrophy from severe VO, their myocardial gene expression remains closer to normal. This could provide survival benefits for females with severe VO.
format	article
author	Catherine Beaumont Élisabeth Walsh-Wilkinson Marie-Claude Drolet Élise Roussel Marie Arsenault Jacques Couet
author_facet	Catherine Beaumont Élisabeth Walsh-Wilkinson Marie-Claude Drolet Élise Roussel Marie Arsenault Jacques Couet
author_sort	Catherine Beaumont
title	Female rats with severe left ventricle volume overload exhibit more cardiac hypertrophy but fewer myocardial transcriptional changes than males
title_short	Female rats with severe left ventricle volume overload exhibit more cardiac hypertrophy but fewer myocardial transcriptional changes than males
title_full	Female rats with severe left ventricle volume overload exhibit more cardiac hypertrophy but fewer myocardial transcriptional changes than males
title_fullStr	Female rats with severe left ventricle volume overload exhibit more cardiac hypertrophy but fewer myocardial transcriptional changes than males
title_full_unstemmed	Female rats with severe left ventricle volume overload exhibit more cardiac hypertrophy but fewer myocardial transcriptional changes than males
title_sort	female rats with severe left ventricle volume overload exhibit more cardiac hypertrophy but fewer myocardial transcriptional changes than males
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/19273e3852134af8ad0171b0556572c3
work_keys_str_mv	AT catherinebeaumont femaleratswithsevereleftventriclevolumeoverloadexhibitmorecardiachypertrophybutfewermyocardialtranscriptionalchangesthanmales AT elisabethwalshwilkinson femaleratswithsevereleftventriclevolumeoverloadexhibitmorecardiachypertrophybutfewermyocardialtranscriptionalchangesthanmales AT marieclaudedrolet femaleratswithsevereleftventriclevolumeoverloadexhibitmorecardiachypertrophybutfewermyocardialtranscriptionalchangesthanmales AT eliseroussel femaleratswithsevereleftventriclevolumeoverloadexhibitmorecardiachypertrophybutfewermyocardialtranscriptionalchangesthanmales AT mariearsenault femaleratswithsevereleftventriclevolumeoverloadexhibitmorecardiachypertrophybutfewermyocardialtranscriptionalchangesthanmales AT jacquescouet femaleratswithsevereleftventriclevolumeoverloadexhibitmorecardiachypertrophybutfewermyocardialtranscriptionalchangesthanmales
_version_	1718385008622698496

Female rats with severe left ventricle volume overload exhibit more cardiac hypertrophy but fewer myocardial transcriptional changes than males

Ejemplares similares