Steroids and mortality in non‐critically ill COVID‐19 patients: a propensity score‐weighted study in a Chilean cohort

Objectives: The aim of this study was to evaluate the impact on 30-day mortality of early use of corticosteroids in COVID-19 patients with supplementary oxygen requirements and without invasive mechanical ventilation at the initiation of therapy. Methods: All patients hospitalized with COVID-19 betw...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: A. Moreno, C. Vargas, F. Azocar, F. Villarroel, M. Cofré, H. Oppliger, F. Ríos, M. Raijmakers, I. Silva-Ayarza, C. Beltrán, F. Zamora
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://doaj.org/article/19290fb3c904465b906f46b56be3c7dd
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:19290fb3c904465b906f46b56be3c7dd
record_format dspace
spelling oai:doaj.org-article:19290fb3c904465b906f46b56be3c7dd2021-11-30T04:14:19ZSteroids and mortality in non‐critically ill COVID‐19 patients: a propensity score‐weighted study in a Chilean cohort1201-971210.1016/j.ijid.2021.09.038https://doaj.org/article/19290fb3c904465b906f46b56be3c7dd2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1201971221007451https://doaj.org/toc/1201-9712Objectives: The aim of this study was to evaluate the impact on 30-day mortality of early use of corticosteroids in COVID-19 patients with supplementary oxygen requirements and without invasive mechanical ventilation at the initiation of therapy. Methods: All patients hospitalized with COVID-19 between April 15 and July 15, 2020, and requiring supplementary oxygen, were prospectively included in a database. Patients who died or required intubation within the first 48 hours were excluded. Patients who received corticosteroids within the first 5 days of hospitalization and at least 24 hours prior to intubation were allocated to the ‘early corticosteroids’ group. To compare both populations and adjust for non-random treatment assignment bias, a weight-adjusted propensity score model was used. Results: In total, 571 patients met the inclusion criteria, 520 had sufficient information for the analysis. Of these, 233 received early corticosteroids and 287 did not. Analysis showed a reduction of 8.5% (p = 0.038) in 30-day mortality in the early corticosteroid group. The reduction in mortality was not significant when patients with corticosteroid initiation between day 5 and day 8 of hospitalization were included. Conclusion: Early corticosteroid use reduced mortality in patients with pneumonia due to COVID-19, who required supplementary oxygen but not initial invasive mechanical ventilation.A. MorenoC. VargasF. AzocarF. VillarroelM. CofréH. OppligerF. RíosM. RaijmakersI. Silva-AyarzaC. BeltránF. ZamoraElsevierarticleChileCOVID-19Latin Americamortalitypropensity scoresteroidsInfectious and parasitic diseasesRC109-216ENInternational Journal of Infectious Diseases, Vol 112, Iss , Pp 124-129 (2021)
institution DOAJ
collection DOAJ
language EN
topic Chile
COVID-19
Latin America
mortality
propensity score
steroids
Infectious and parasitic diseases
RC109-216
spellingShingle Chile
COVID-19
Latin America
mortality
propensity score
steroids
Infectious and parasitic diseases
RC109-216
A. Moreno
C. Vargas
F. Azocar
F. Villarroel
M. Cofré
H. Oppliger
F. Ríos
M. Raijmakers
I. Silva-Ayarza
C. Beltrán
F. Zamora
Steroids and mortality in non‐critically ill COVID‐19 patients: a propensity score‐weighted study in a Chilean cohort
description Objectives: The aim of this study was to evaluate the impact on 30-day mortality of early use of corticosteroids in COVID-19 patients with supplementary oxygen requirements and without invasive mechanical ventilation at the initiation of therapy. Methods: All patients hospitalized with COVID-19 between April 15 and July 15, 2020, and requiring supplementary oxygen, were prospectively included in a database. Patients who died or required intubation within the first 48 hours were excluded. Patients who received corticosteroids within the first 5 days of hospitalization and at least 24 hours prior to intubation were allocated to the ‘early corticosteroids’ group. To compare both populations and adjust for non-random treatment assignment bias, a weight-adjusted propensity score model was used. Results: In total, 571 patients met the inclusion criteria, 520 had sufficient information for the analysis. Of these, 233 received early corticosteroids and 287 did not. Analysis showed a reduction of 8.5% (p = 0.038) in 30-day mortality in the early corticosteroid group. The reduction in mortality was not significant when patients with corticosteroid initiation between day 5 and day 8 of hospitalization were included. Conclusion: Early corticosteroid use reduced mortality in patients with pneumonia due to COVID-19, who required supplementary oxygen but not initial invasive mechanical ventilation.
format article
author A. Moreno
C. Vargas
F. Azocar
F. Villarroel
M. Cofré
H. Oppliger
F. Ríos
M. Raijmakers
I. Silva-Ayarza
C. Beltrán
F. Zamora
author_facet A. Moreno
C. Vargas
F. Azocar
F. Villarroel
M. Cofré
H. Oppliger
F. Ríos
M. Raijmakers
I. Silva-Ayarza
C. Beltrán
F. Zamora
author_sort A. Moreno
title Steroids and mortality in non‐critically ill COVID‐19 patients: a propensity score‐weighted study in a Chilean cohort
title_short Steroids and mortality in non‐critically ill COVID‐19 patients: a propensity score‐weighted study in a Chilean cohort
title_full Steroids and mortality in non‐critically ill COVID‐19 patients: a propensity score‐weighted study in a Chilean cohort
title_fullStr Steroids and mortality in non‐critically ill COVID‐19 patients: a propensity score‐weighted study in a Chilean cohort
title_full_unstemmed Steroids and mortality in non‐critically ill COVID‐19 patients: a propensity score‐weighted study in a Chilean cohort
title_sort steroids and mortality in non‐critically ill covid‐19 patients: a propensity score‐weighted study in a chilean cohort
publisher Elsevier
publishDate 2021
url https://doaj.org/article/19290fb3c904465b906f46b56be3c7dd
work_keys_str_mv AT amoreno steroidsandmortalityinnoncriticallyillcovid19patientsapropensityscoreweightedstudyinachileancohort
AT cvargas steroidsandmortalityinnoncriticallyillcovid19patientsapropensityscoreweightedstudyinachileancohort
AT fazocar steroidsandmortalityinnoncriticallyillcovid19patientsapropensityscoreweightedstudyinachileancohort
AT fvillarroel steroidsandmortalityinnoncriticallyillcovid19patientsapropensityscoreweightedstudyinachileancohort
AT mcofre steroidsandmortalityinnoncriticallyillcovid19patientsapropensityscoreweightedstudyinachileancohort
AT hoppliger steroidsandmortalityinnoncriticallyillcovid19patientsapropensityscoreweightedstudyinachileancohort
AT frios steroidsandmortalityinnoncriticallyillcovid19patientsapropensityscoreweightedstudyinachileancohort
AT mraijmakers steroidsandmortalityinnoncriticallyillcovid19patientsapropensityscoreweightedstudyinachileancohort
AT isilvaayarza steroidsandmortalityinnoncriticallyillcovid19patientsapropensityscoreweightedstudyinachileancohort
AT cbeltran steroidsandmortalityinnoncriticallyillcovid19patientsapropensityscoreweightedstudyinachileancohort
AT fzamora steroidsandmortalityinnoncriticallyillcovid19patientsapropensityscoreweightedstudyinachileancohort
_version_ 1718406788549705728