Steroids and mortality in non‐critically ill COVID‐19 patients: a propensity score‐weighted study in a Chilean cohort
Objectives: The aim of this study was to evaluate the impact on 30-day mortality of early use of corticosteroids in COVID-19 patients with supplementary oxygen requirements and without invasive mechanical ventilation at the initiation of therapy. Methods: All patients hospitalized with COVID-19 betw...
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2021
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oai:doaj.org-article:19290fb3c904465b906f46b56be3c7dd2021-11-30T04:14:19ZSteroids and mortality in non‐critically ill COVID‐19 patients: a propensity score‐weighted study in a Chilean cohort1201-971210.1016/j.ijid.2021.09.038https://doaj.org/article/19290fb3c904465b906f46b56be3c7dd2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1201971221007451https://doaj.org/toc/1201-9712Objectives: The aim of this study was to evaluate the impact on 30-day mortality of early use of corticosteroids in COVID-19 patients with supplementary oxygen requirements and without invasive mechanical ventilation at the initiation of therapy. Methods: All patients hospitalized with COVID-19 between April 15 and July 15, 2020, and requiring supplementary oxygen, were prospectively included in a database. Patients who died or required intubation within the first 48 hours were excluded. Patients who received corticosteroids within the first 5 days of hospitalization and at least 24 hours prior to intubation were allocated to the ‘early corticosteroids’ group. To compare both populations and adjust for non-random treatment assignment bias, a weight-adjusted propensity score model was used. Results: In total, 571 patients met the inclusion criteria, 520 had sufficient information for the analysis. Of these, 233 received early corticosteroids and 287 did not. Analysis showed a reduction of 8.5% (p = 0.038) in 30-day mortality in the early corticosteroid group. The reduction in mortality was not significant when patients with corticosteroid initiation between day 5 and day 8 of hospitalization were included. Conclusion: Early corticosteroid use reduced mortality in patients with pneumonia due to COVID-19, who required supplementary oxygen but not initial invasive mechanical ventilation.A. MorenoC. VargasF. AzocarF. VillarroelM. CofréH. OppligerF. RíosM. RaijmakersI. Silva-AyarzaC. BeltránF. ZamoraElsevierarticleChileCOVID-19Latin Americamortalitypropensity scoresteroidsInfectious and parasitic diseasesRC109-216ENInternational Journal of Infectious Diseases, Vol 112, Iss , Pp 124-129 (2021) |
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Chile COVID-19 Latin America mortality propensity score steroids Infectious and parasitic diseases RC109-216 |
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Chile COVID-19 Latin America mortality propensity score steroids Infectious and parasitic diseases RC109-216 A. Moreno C. Vargas F. Azocar F. Villarroel M. Cofré H. Oppliger F. Ríos M. Raijmakers I. Silva-Ayarza C. Beltrán F. Zamora Steroids and mortality in non‐critically ill COVID‐19 patients: a propensity score‐weighted study in a Chilean cohort |
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Objectives: The aim of this study was to evaluate the impact on 30-day mortality of early use of corticosteroids in COVID-19 patients with supplementary oxygen requirements and without invasive mechanical ventilation at the initiation of therapy. Methods: All patients hospitalized with COVID-19 between April 15 and July 15, 2020, and requiring supplementary oxygen, were prospectively included in a database. Patients who died or required intubation within the first 48 hours were excluded. Patients who received corticosteroids within the first 5 days of hospitalization and at least 24 hours prior to intubation were allocated to the ‘early corticosteroids’ group. To compare both populations and adjust for non-random treatment assignment bias, a weight-adjusted propensity score model was used. Results: In total, 571 patients met the inclusion criteria, 520 had sufficient information for the analysis. Of these, 233 received early corticosteroids and 287 did not. Analysis showed a reduction of 8.5% (p = 0.038) in 30-day mortality in the early corticosteroid group. The reduction in mortality was not significant when patients with corticosteroid initiation between day 5 and day 8 of hospitalization were included. Conclusion: Early corticosteroid use reduced mortality in patients with pneumonia due to COVID-19, who required supplementary oxygen but not initial invasive mechanical ventilation. |
format |
article |
author |
A. Moreno C. Vargas F. Azocar F. Villarroel M. Cofré H. Oppliger F. Ríos M. Raijmakers I. Silva-Ayarza C. Beltrán F. Zamora |
author_facet |
A. Moreno C. Vargas F. Azocar F. Villarroel M. Cofré H. Oppliger F. Ríos M. Raijmakers I. Silva-Ayarza C. Beltrán F. Zamora |
author_sort |
A. Moreno |
title |
Steroids and mortality in non‐critically ill COVID‐19 patients: a propensity score‐weighted study in a Chilean cohort |
title_short |
Steroids and mortality in non‐critically ill COVID‐19 patients: a propensity score‐weighted study in a Chilean cohort |
title_full |
Steroids and mortality in non‐critically ill COVID‐19 patients: a propensity score‐weighted study in a Chilean cohort |
title_fullStr |
Steroids and mortality in non‐critically ill COVID‐19 patients: a propensity score‐weighted study in a Chilean cohort |
title_full_unstemmed |
Steroids and mortality in non‐critically ill COVID‐19 patients: a propensity score‐weighted study in a Chilean cohort |
title_sort |
steroids and mortality in non‐critically ill covid‐19 patients: a propensity score‐weighted study in a chilean cohort |
publisher |
Elsevier |
publishDate |
2021 |
url |
https://doaj.org/article/19290fb3c904465b906f46b56be3c7dd |
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