Drug susceptibility profiling of pulmonary Mycobacterium kansasii and its correlation with treatment outcome

OBJECTIVES: With the introduction of newer molecular diagnostic tools to identify Mycobacterium tuberculosis, an increasing number of nontuberculous mycobacterium (NTM) is being identified. However, the drug resistance pattern of the NTM species identified is less explored. The objective of this stu...

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Autores principales:	Priya Rajendran, Chandrasekaran Padmapriyadarsini, Vaishnavee Vijayaraghavan, Tamizhselvan Manoharan, Lakshana Malla Lokanathan, Parveen Banu Kadhar, Lavanya Jayabal, Gomathy Sivaramakrishnan
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	drug regimen drug susceptibility testing mycobacterium kansasii misdiagnosis nontuberculous mycobacterium tuberculosis Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the respiratory system RC705-779
Acceso en línea:	https://doaj.org/article/192c0500994e421caa505acec0fbd5c1
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spelling	oai:doaj.org-article:192c0500994e421caa505acec0fbd5c12021-11-12T10:08:17ZDrug susceptibility profiling of pulmonary Mycobacterium kansasii and its correlation with treatment outcome1817-17371998-355710.4103/atm.atm_45_21https://doaj.org/article/192c0500994e421caa505acec0fbd5c12021-01-01T00:00:00Zhttp://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2021;volume=16;issue=4;spage=323;epage=328;aulast=Rajendranhttps://doaj.org/toc/1817-1737https://doaj.org/toc/1998-3557OBJECTIVES: With the introduction of newer molecular diagnostic tools to identify Mycobacterium tuberculosis, an increasing number of nontuberculous mycobacterium (NTM) is being identified. However, the drug resistance pattern of the NTM species identified is less explored. The objective of this study is to study the drug resistance patterns of Mycobacterium kansasii species isolated in a tuberculosis-endemic setting at South India.METHODS: A wide profile of NTM species were reported earlier from a prospective cohort of adults during 2017–2020. Out of this profile, a total of 22 M. kansasii species were subjected to drug susceptibility testing by two different methods: proportion sensitivity testing method and Sensititre testing method.RESULTS: Out of the 18 strains of M. kansasii subjected to Sensititre method of testing, the resistance pattern was demonstrated to be high for doxycycline (13) followed by rifampicin and trimethoprim/sulfamethoxazole (7). Out of the 22 strains subjected to proportion sensitivity testing method, 20 and 10 were resistant to isoniazid and ethambutol, respectively.CONCLUSION: There was a poor correlation between the treatment outcome and the resistance pattern of the antibiotics tested. With increasing numbers of NTM being reported, early and correct identification of NTM species is essential for the prompt initiation of appropriate treatment to achieve better outcome.Priya RajendranChandrasekaran PadmapriyadarsiniVaishnavee VijayaraghavanTamizhselvan ManoharanLakshana Malla LokanathanParveen Banu KadharLavanya JayabalGomathy SivaramakrishnanWolters Kluwer Medknow Publicationsarticledrug regimendrug susceptibility testing mycobacterium kansasii misdiagnosisnontuberculous mycobacteriumtuberculosisDiseases of the circulatory (Cardiovascular) systemRC666-701Diseases of the respiratory systemRC705-779ENAnnals of Thoracic Medicine, Vol 16, Iss 4, Pp 323-328 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	drug regimen drug susceptibility testing mycobacterium kansasii misdiagnosis nontuberculous mycobacterium tuberculosis Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the respiratory system RC705-779
spellingShingle	drug regimen drug susceptibility testing mycobacterium kansasii misdiagnosis nontuberculous mycobacterium tuberculosis Diseases of the circulatory (Cardiovascular) system RC666-701 Diseases of the respiratory system RC705-779 Priya Rajendran Chandrasekaran Padmapriyadarsini Vaishnavee Vijayaraghavan Tamizhselvan Manoharan Lakshana Malla Lokanathan Parveen Banu Kadhar Lavanya Jayabal Gomathy Sivaramakrishnan Drug susceptibility profiling of pulmonary Mycobacterium kansasii and its correlation with treatment outcome
description	OBJECTIVES: With the introduction of newer molecular diagnostic tools to identify Mycobacterium tuberculosis, an increasing number of nontuberculous mycobacterium (NTM) is being identified. However, the drug resistance pattern of the NTM species identified is less explored. The objective of this study is to study the drug resistance patterns of Mycobacterium kansasii species isolated in a tuberculosis-endemic setting at South India.METHODS: A wide profile of NTM species were reported earlier from a prospective cohort of adults during 2017–2020. Out of this profile, a total of 22 M. kansasii species were subjected to drug susceptibility testing by two different methods: proportion sensitivity testing method and Sensititre testing method.RESULTS: Out of the 18 strains of M. kansasii subjected to Sensititre method of testing, the resistance pattern was demonstrated to be high for doxycycline (13) followed by rifampicin and trimethoprim/sulfamethoxazole (7). Out of the 22 strains subjected to proportion sensitivity testing method, 20 and 10 were resistant to isoniazid and ethambutol, respectively.CONCLUSION: There was a poor correlation between the treatment outcome and the resistance pattern of the antibiotics tested. With increasing numbers of NTM being reported, early and correct identification of NTM species is essential for the prompt initiation of appropriate treatment to achieve better outcome.
format	article
author	Priya Rajendran Chandrasekaran Padmapriyadarsini Vaishnavee Vijayaraghavan Tamizhselvan Manoharan Lakshana Malla Lokanathan Parveen Banu Kadhar Lavanya Jayabal Gomathy Sivaramakrishnan
author_facet	Priya Rajendran Chandrasekaran Padmapriyadarsini Vaishnavee Vijayaraghavan Tamizhselvan Manoharan Lakshana Malla Lokanathan Parveen Banu Kadhar Lavanya Jayabal Gomathy Sivaramakrishnan
author_sort	Priya Rajendran
title	Drug susceptibility profiling of pulmonary Mycobacterium kansasii and its correlation with treatment outcome
title_short	Drug susceptibility profiling of pulmonary Mycobacterium kansasii and its correlation with treatment outcome
title_full	Drug susceptibility profiling of pulmonary Mycobacterium kansasii and its correlation with treatment outcome
title_fullStr	Drug susceptibility profiling of pulmonary Mycobacterium kansasii and its correlation with treatment outcome
title_full_unstemmed	Drug susceptibility profiling of pulmonary Mycobacterium kansasii and its correlation with treatment outcome
title_sort	drug susceptibility profiling of pulmonary mycobacterium kansasii and its correlation with treatment outcome
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/192c0500994e421caa505acec0fbd5c1
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Drug susceptibility profiling of pulmonary Mycobacterium kansasii and its correlation with treatment outcome

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