Emerging Approaches for Solid Tumor Treatment Using CAR-T Cell Therapy

Cancer immunotherapy is becoming more important in the clinical setting, especially for cancers resistant to conventional chemotherapy, including targeted therapy. Chimeric antigen receptor (CAR)-T cell therapy, which uses patient’s autologous T cells, combined with engineered T cell receptors, has...

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Autores principales:	Hyunmin Chung, Haiyoung Jung, Ji-Yoon Noh
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	CAR-T cell solid tumor challenge combination therapy Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/192dd63798f2443bbb6af39f4069e7fc
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spelling	oai:doaj.org-article:192dd63798f2443bbb6af39f4069e7fc2021-11-25T17:53:36ZEmerging Approaches for Solid Tumor Treatment Using CAR-T Cell Therapy10.3390/ijms2222121261422-00671661-6596https://doaj.org/article/192dd63798f2443bbb6af39f4069e7fc2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12126https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Cancer immunotherapy is becoming more important in the clinical setting, especially for cancers resistant to conventional chemotherapy, including targeted therapy. Chimeric antigen receptor (CAR)-T cell therapy, which uses patient’s autologous T cells, combined with engineered T cell receptors, has shown remarkable results, with five US Food and Drug Administration (FDA) approvals to date. CAR-T cells have been very effective in hematologic malignancies, such as diffuse large B cell lymphoma (DLBCL), B cell acute lymphoblastic leukemia (B-ALL), and multiple myeloma (MM); however, its effectiveness in treating solid tumors has not been evaluated clearly. Therefore, many studies and clinical investigations are emerging to improve the CAR-T cell efficacy in solid tumors. The novel therapeutic approaches include modifying CARs in multiple ways or developing a combination therapy with immune checkpoint inhibitors and chemotherapies. In this review, we focus on the challenges and recent advancements in CAR-T cell therapy for solid tumors.Hyunmin ChungHaiyoung JungJi-Yoon NohMDPI AGarticleCAR-T cellsolid tumorchallengecombination therapyBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12126, p 12126 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	CAR-T cell solid tumor challenge combination therapy Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	CAR-T cell solid tumor challenge combination therapy Biology (General) QH301-705.5 Chemistry QD1-999 Hyunmin Chung Haiyoung Jung Ji-Yoon Noh Emerging Approaches for Solid Tumor Treatment Using CAR-T Cell Therapy
description	Cancer immunotherapy is becoming more important in the clinical setting, especially for cancers resistant to conventional chemotherapy, including targeted therapy. Chimeric antigen receptor (CAR)-T cell therapy, which uses patient’s autologous T cells, combined with engineered T cell receptors, has shown remarkable results, with five US Food and Drug Administration (FDA) approvals to date. CAR-T cells have been very effective in hematologic malignancies, such as diffuse large B cell lymphoma (DLBCL), B cell acute lymphoblastic leukemia (B-ALL), and multiple myeloma (MM); however, its effectiveness in treating solid tumors has not been evaluated clearly. Therefore, many studies and clinical investigations are emerging to improve the CAR-T cell efficacy in solid tumors. The novel therapeutic approaches include modifying CARs in multiple ways or developing a combination therapy with immune checkpoint inhibitors and chemotherapies. In this review, we focus on the challenges and recent advancements in CAR-T cell therapy for solid tumors.
format	article
author	Hyunmin Chung Haiyoung Jung Ji-Yoon Noh
author_facet	Hyunmin Chung Haiyoung Jung Ji-Yoon Noh
author_sort	Hyunmin Chung
title	Emerging Approaches for Solid Tumor Treatment Using CAR-T Cell Therapy
title_short	Emerging Approaches for Solid Tumor Treatment Using CAR-T Cell Therapy
title_full	Emerging Approaches for Solid Tumor Treatment Using CAR-T Cell Therapy
title_fullStr	Emerging Approaches for Solid Tumor Treatment Using CAR-T Cell Therapy
title_full_unstemmed	Emerging Approaches for Solid Tumor Treatment Using CAR-T Cell Therapy
title_sort	emerging approaches for solid tumor treatment using car-t cell therapy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/192dd63798f2443bbb6af39f4069e7fc
work_keys_str_mv	AT hyunminchung emergingapproachesforsolidtumortreatmentusingcartcelltherapy AT haiyoungjung emergingapproachesforsolidtumortreatmentusingcartcelltherapy AT jiyoonnoh emergingapproachesforsolidtumortreatmentusingcartcelltherapy
_version_	1718411847961411584

Emerging Approaches for Solid Tumor Treatment Using CAR-T Cell Therapy

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