Catalytic asymmetric nucleophilic fluorination using BF3·Et2O as fluorine source and activating reagent

Catalytic asymmetric nucleophilic fluorination using BF3·Et2O as fluorine source and activating reagent

Catalytic asymmetric fluorination remains elusive, especially the longstanding stereochemical challenges which exist in BF3Et2O-based fluorinations. Here the authors show a catalytic asymmetric nucleophilic fluorination using BF3·Et2O as the fluorine reagent in the presence of chiral iodine catalyst...

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Autores principales: Weiwei Zhu, Xiang Zhen, Jingyuan Wu, Yaping Cheng, Junkai An, Xingyu Ma, Jikun Liu, Yuji Qin, Hao Zhu, Jijun Xue, Xianxing Jiang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/192debc183404b709840ddf4ba15cc9e
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spelling oai:doaj.org-article:192debc183404b709840ddf4ba15cc9e2021-12-02T17:44:59ZCatalytic asymmetric nucleophilic fluorination using BF3·Et2O as fluorine source and activating reagent10.1038/s41467-021-24278-32041-1723https://doaj.org/article/192debc183404b709840ddf4ba15cc9e2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24278-3https://doaj.org/toc/2041-1723Catalytic asymmetric fluorination remains elusive, especially the longstanding stereochemical challenges which exist in BF3Et2O-based fluorinations. Here the authors show a catalytic asymmetric nucleophilic fluorination using BF3·Et2O as the fluorine reagent in the presence of chiral iodine catalyst.Weiwei ZhuXiang ZhenJingyuan WuYaping ChengJunkai AnXingyu MaJikun LiuYuji QinHao ZhuJijun XueXianxing JiangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Weiwei Zhu
Xiang Zhen
Jingyuan Wu
Yaping Cheng
Junkai An
Xingyu Ma
Jikun Liu
Yuji Qin
Hao Zhu
Jijun Xue
Xianxing Jiang
Catalytic asymmetric nucleophilic fluorination using BF3·Et2O as fluorine source and activating reagent
description Catalytic asymmetric fluorination remains elusive, especially the longstanding stereochemical challenges which exist in BF3Et2O-based fluorinations. Here the authors show a catalytic asymmetric nucleophilic fluorination using BF3·Et2O as the fluorine reagent in the presence of chiral iodine catalyst.
format article
author Weiwei Zhu
Xiang Zhen
Jingyuan Wu
Yaping Cheng
Junkai An
Xingyu Ma
Jikun Liu
Yuji Qin
Hao Zhu
Jijun Xue
Xianxing Jiang
author_facet Weiwei Zhu
Xiang Zhen
Jingyuan Wu
Yaping Cheng
Junkai An
Xingyu Ma
Jikun Liu
Yuji Qin
Hao Zhu
Jijun Xue
Xianxing Jiang
author_sort Weiwei Zhu
title Catalytic asymmetric nucleophilic fluorination using BF3·Et2O as fluorine source and activating reagent
title_short Catalytic asymmetric nucleophilic fluorination using BF3·Et2O as fluorine source and activating reagent
title_full Catalytic asymmetric nucleophilic fluorination using BF3·Et2O as fluorine source and activating reagent
title_fullStr Catalytic asymmetric nucleophilic fluorination using BF3·Et2O as fluorine source and activating reagent
title_full_unstemmed Catalytic asymmetric nucleophilic fluorination using BF3·Et2O as fluorine source and activating reagent
title_sort catalytic asymmetric nucleophilic fluorination using bf3·et2o as fluorine source and activating reagent
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/192debc183404b709840ddf4ba15cc9e
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AT yujiqin catalyticasymmetricnucleophilicfluorinationusingbf3et2oasfluorinesourceandactivatingreagent
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