Identification of two major autoantigens negatively regulating endothelial activation in Takayasu arteritis

Autoantibodies against endothelium have been recognized in Takayasu arteritis (TAK). Here the authors identify endothelial protein C receptor and scavenger receptor class B type 1 as major autoantigens in TAK, and find autoantibodies inhibit the negative regulation of endothelial activation.

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Autores principales:	Tomoyuki Mutoh, Tsuyoshi Shirai, Tomonori Ishii, Yuko Shirota, Fumiyoshi Fujishima, Fumiaki Takahashi, Yoichi Kakuta, Yoshitake Kanazawa, Atsushi Masamune, Yoshikatsu Saiki, Hideo Harigae, Hiroshi Fujii
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/192eadb852e54eccb4c6ea32d8f3dee2
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spelling	oai:doaj.org-article:192eadb852e54eccb4c6ea32d8f3dee22021-12-02T16:49:15ZIdentification of two major autoantigens negatively regulating endothelial activation in Takayasu arteritis10.1038/s41467-020-15088-02041-1723https://doaj.org/article/192eadb852e54eccb4c6ea32d8f3dee22020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15088-0https://doaj.org/toc/2041-1723Autoantibodies against endothelium have been recognized in Takayasu arteritis (TAK). Here the authors identify endothelial protein C receptor and scavenger receptor class B type 1 as major autoantigens in TAK, and find autoantibodies inhibit the negative regulation of endothelial activation.Tomoyuki MutohTsuyoshi ShiraiTomonori IshiiYuko ShirotaFumiyoshi FujishimaFumiaki TakahashiYoichi KakutaYoshitake KanazawaAtsushi MasamuneYoshikatsu SaikiHideo HarigaeHiroshi FujiiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tomoyuki Mutoh Tsuyoshi Shirai Tomonori Ishii Yuko Shirota Fumiyoshi Fujishima Fumiaki Takahashi Yoichi Kakuta Yoshitake Kanazawa Atsushi Masamune Yoshikatsu Saiki Hideo Harigae Hiroshi Fujii Identification of two major autoantigens negatively regulating endothelial activation in Takayasu arteritis
description	Autoantibodies against endothelium have been recognized in Takayasu arteritis (TAK). Here the authors identify endothelial protein C receptor and scavenger receptor class B type 1 as major autoantigens in TAK, and find autoantibodies inhibit the negative regulation of endothelial activation.
format	article
author	Tomoyuki Mutoh Tsuyoshi Shirai Tomonori Ishii Yuko Shirota Fumiyoshi Fujishima Fumiaki Takahashi Yoichi Kakuta Yoshitake Kanazawa Atsushi Masamune Yoshikatsu Saiki Hideo Harigae Hiroshi Fujii
author_facet	Tomoyuki Mutoh Tsuyoshi Shirai Tomonori Ishii Yuko Shirota Fumiyoshi Fujishima Fumiaki Takahashi Yoichi Kakuta Yoshitake Kanazawa Atsushi Masamune Yoshikatsu Saiki Hideo Harigae Hiroshi Fujii
author_sort	Tomoyuki Mutoh
title	Identification of two major autoantigens negatively regulating endothelial activation in Takayasu arteritis
title_short	Identification of two major autoantigens negatively regulating endothelial activation in Takayasu arteritis
title_full	Identification of two major autoantigens negatively regulating endothelial activation in Takayasu arteritis
title_fullStr	Identification of two major autoantigens negatively regulating endothelial activation in Takayasu arteritis
title_full_unstemmed	Identification of two major autoantigens negatively regulating endothelial activation in Takayasu arteritis
title_sort	identification of two major autoantigens negatively regulating endothelial activation in takayasu arteritis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/192eadb852e54eccb4c6ea32d8f3dee2
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Identification of two major autoantigens negatively regulating endothelial activation in Takayasu arteritis

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