Effects of Early vs. Late Time-Restricted Eating on Cardiometabolic Health, Inflammation, and Sleep in Overweight and Obese Women: A Study Protocol for the ChronoFast Trial

Background: Time-restricted eating is a promising dietary strategy for weight loss, glucose and lipid metabolism improvements, and overall well-being. However, human studies demonstrated contradictory results for the restriction of food intake to the beginning (early TRE, eTRE) or to the end of the...

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Autores principales:	Beeke Peters, Daniela A. Koppold-Liebscher, Bettina Schuppelius, Nico Steckhan, Andreas F. H. Pfeiffer, Achim Kramer, Andreas Michalsen, Olga Pivovarova-Ramich
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	time-restricted eating meal timing circadian clock obesity diabetes metabolism Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/19317d04c0f04f83b8d01e2f4aa09d47
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spelling	oai:doaj.org-article:19317d04c0f04f83b8d01e2f4aa09d472021-11-15T06:57:01ZEffects of Early vs. Late Time-Restricted Eating on Cardiometabolic Health, Inflammation, and Sleep in Overweight and Obese Women: A Study Protocol for the ChronoFast Trial2296-861X10.3389/fnut.2021.765543https://doaj.org/article/19317d04c0f04f83b8d01e2f4aa09d472021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnut.2021.765543/fullhttps://doaj.org/toc/2296-861XBackground: Time-restricted eating is a promising dietary strategy for weight loss, glucose and lipid metabolism improvements, and overall well-being. However, human studies demonstrated contradictory results for the restriction of food intake to the beginning (early TRE, eTRE) or to the end of the day (late TRE, lTRE) suggesting that more carefully controlled studies are needed.Objective: The aim of the ChronoFast trial study is to determine whether eTRE or lTRE is a better dietary approach to improve cardiometabolic health upon minimized calorie deficits and nearly stable body weight.Methods: Here, we present the study protocol of the randomized cross-over ChronoFast clinical trial comparing effects of 2 week eTRE (8:00 to 16:00 h) and lTRE (13:00 to 21:00 h) on insulin sensitivity and other glycemic traits, blood lipids, inflammation, and sleep quality in 30 women with overweight or obesity and increased risk of type 2 diabetes. To ensure timely compliance and unchanged dietary composition, and to minimize possible calorie deficits, real-time monitoring of dietary intake and body weight using a smartphone application, and extensive nutritional counseling are performed. Continuous glucose monitoring, oral glucose tolerance test, 24 h activity tracking, questionnaires, and gene expression analysis in adipose tissue and blood monocytes will be used for assessment of study outcomes.Discussion: The trial will determine whether eTRE or lTRE is more effective to improve cardiometabolic health, elucidate underlying mechanisms, and contribute to the development of recommendations for medical practice and the wider population.Clinical Trial Registration:www.ClinicalTrials.gov, Identifier [NCT04351672]Beeke PetersBeeke PetersDaniela A. Koppold-LiebscherBettina SchuppeliusBettina SchuppeliusNico SteckhanNico SteckhanAndreas F. H. PfeifferAndreas F. H. PfeifferAchim KramerAndreas MichalsenAndreas MichalsenOlga Pivovarova-RamichOlga Pivovarova-RamichOlga Pivovarova-RamichFrontiers Media S.A.articletime-restricted eatingmeal timingcircadian clockobesitydiabetesmetabolismNutrition. Foods and food supplyTX341-641ENFrontiers in Nutrition, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	time-restricted eating meal timing circadian clock obesity diabetes metabolism Nutrition. Foods and food supply TX341-641
spellingShingle	time-restricted eating meal timing circadian clock obesity diabetes metabolism Nutrition. Foods and food supply TX341-641 Beeke Peters Beeke Peters Daniela A. Koppold-Liebscher Bettina Schuppelius Bettina Schuppelius Nico Steckhan Nico Steckhan Andreas F. H. Pfeiffer Andreas F. H. Pfeiffer Achim Kramer Andreas Michalsen Andreas Michalsen Olga Pivovarova-Ramich Olga Pivovarova-Ramich Olga Pivovarova-Ramich Effects of Early vs. Late Time-Restricted Eating on Cardiometabolic Health, Inflammation, and Sleep in Overweight and Obese Women: A Study Protocol for the ChronoFast Trial
description	Background: Time-restricted eating is a promising dietary strategy for weight loss, glucose and lipid metabolism improvements, and overall well-being. However, human studies demonstrated contradictory results for the restriction of food intake to the beginning (early TRE, eTRE) or to the end of the day (late TRE, lTRE) suggesting that more carefully controlled studies are needed.Objective: The aim of the ChronoFast trial study is to determine whether eTRE or lTRE is a better dietary approach to improve cardiometabolic health upon minimized calorie deficits and nearly stable body weight.Methods: Here, we present the study protocol of the randomized cross-over ChronoFast clinical trial comparing effects of 2 week eTRE (8:00 to 16:00 h) and lTRE (13:00 to 21:00 h) on insulin sensitivity and other glycemic traits, blood lipids, inflammation, and sleep quality in 30 women with overweight or obesity and increased risk of type 2 diabetes. To ensure timely compliance and unchanged dietary composition, and to minimize possible calorie deficits, real-time monitoring of dietary intake and body weight using a smartphone application, and extensive nutritional counseling are performed. Continuous glucose monitoring, oral glucose tolerance test, 24 h activity tracking, questionnaires, and gene expression analysis in adipose tissue and blood monocytes will be used for assessment of study outcomes.Discussion: The trial will determine whether eTRE or lTRE is more effective to improve cardiometabolic health, elucidate underlying mechanisms, and contribute to the development of recommendations for medical practice and the wider population.Clinical Trial Registration:www.ClinicalTrials.gov, Identifier [NCT04351672]
format	article
author	Beeke Peters Beeke Peters Daniela A. Koppold-Liebscher Bettina Schuppelius Bettina Schuppelius Nico Steckhan Nico Steckhan Andreas F. H. Pfeiffer Andreas F. H. Pfeiffer Achim Kramer Andreas Michalsen Andreas Michalsen Olga Pivovarova-Ramich Olga Pivovarova-Ramich Olga Pivovarova-Ramich
author_facet	Beeke Peters Beeke Peters Daniela A. Koppold-Liebscher Bettina Schuppelius Bettina Schuppelius Nico Steckhan Nico Steckhan Andreas F. H. Pfeiffer Andreas F. H. Pfeiffer Achim Kramer Andreas Michalsen Andreas Michalsen Olga Pivovarova-Ramich Olga Pivovarova-Ramich Olga Pivovarova-Ramich
author_sort	Beeke Peters
title	Effects of Early vs. Late Time-Restricted Eating on Cardiometabolic Health, Inflammation, and Sleep in Overweight and Obese Women: A Study Protocol for the ChronoFast Trial
title_short	Effects of Early vs. Late Time-Restricted Eating on Cardiometabolic Health, Inflammation, and Sleep in Overweight and Obese Women: A Study Protocol for the ChronoFast Trial
title_full	Effects of Early vs. Late Time-Restricted Eating on Cardiometabolic Health, Inflammation, and Sleep in Overweight and Obese Women: A Study Protocol for the ChronoFast Trial
title_fullStr	Effects of Early vs. Late Time-Restricted Eating on Cardiometabolic Health, Inflammation, and Sleep in Overweight and Obese Women: A Study Protocol for the ChronoFast Trial
title_full_unstemmed	Effects of Early vs. Late Time-Restricted Eating on Cardiometabolic Health, Inflammation, and Sleep in Overweight and Obese Women: A Study Protocol for the ChronoFast Trial
title_sort	effects of early vs. late time-restricted eating on cardiometabolic health, inflammation, and sleep in overweight and obese women: a study protocol for the chronofast trial
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/19317d04c0f04f83b8d01e2f4aa09d47
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Effects of Early vs. Late Time-Restricted Eating on Cardiometabolic Health, Inflammation, and Sleep in Overweight and Obese Women: A Study Protocol for the ChronoFast Trial

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