CaMKII induces permeability transition through Drp1 phosphorylation during chronic β-AR stimulation

β-adrenergic receptor signaling induces mitochondrial permeability transition pore (mPTP) opening. Here, Xuet al. show that this effect is mediated by phosphorylation of mitochondrial fission protein Drp1 by CamKII, which increases the frequency of transient mPTP opening.

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Auteurs principaux:	Shangcheng Xu, Pei Wang, Huiliang Zhang, Guohua Gong, Nicolas Gutierrez Cortes, Weizhong Zhu, Yisang Yoon, Rong Tian, Wang Wang
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2016
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/193253a2af8e40d1889ff8f4ed1f6ac6
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id	oai:doaj.org-article:193253a2af8e40d1889ff8f4ed1f6ac6
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spelling	oai:doaj.org-article:193253a2af8e40d1889ff8f4ed1f6ac62021-12-02T15:35:43ZCaMKII induces permeability transition through Drp1 phosphorylation during chronic β-AR stimulation10.1038/ncomms131892041-1723https://doaj.org/article/193253a2af8e40d1889ff8f4ed1f6ac62016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13189https://doaj.org/toc/2041-1723β-adrenergic receptor signaling induces mitochondrial permeability transition pore (mPTP) opening. Here, Xuet al. show that this effect is mediated by phosphorylation of mitochondrial fission protein Drp1 by CamKII, which increases the frequency of transient mPTP opening.Shangcheng XuPei WangHuiliang ZhangGuohua GongNicolas Gutierrez CortesWeizhong ZhuYisang YoonRong TianWang WangNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shangcheng Xu Pei Wang Huiliang Zhang Guohua Gong Nicolas Gutierrez Cortes Weizhong Zhu Yisang Yoon Rong Tian Wang Wang CaMKII induces permeability transition through Drp1 phosphorylation during chronic β-AR stimulation
description	β-adrenergic receptor signaling induces mitochondrial permeability transition pore (mPTP) opening. Here, Xuet al. show that this effect is mediated by phosphorylation of mitochondrial fission protein Drp1 by CamKII, which increases the frequency of transient mPTP opening.
format	article
author	Shangcheng Xu Pei Wang Huiliang Zhang Guohua Gong Nicolas Gutierrez Cortes Weizhong Zhu Yisang Yoon Rong Tian Wang Wang
author_facet	Shangcheng Xu Pei Wang Huiliang Zhang Guohua Gong Nicolas Gutierrez Cortes Weizhong Zhu Yisang Yoon Rong Tian Wang Wang
author_sort	Shangcheng Xu
title	CaMKII induces permeability transition through Drp1 phosphorylation during chronic β-AR stimulation
title_short	CaMKII induces permeability transition through Drp1 phosphorylation during chronic β-AR stimulation
title_full	CaMKII induces permeability transition through Drp1 phosphorylation during chronic β-AR stimulation
title_fullStr	CaMKII induces permeability transition through Drp1 phosphorylation during chronic β-AR stimulation
title_full_unstemmed	CaMKII induces permeability transition through Drp1 phosphorylation during chronic β-AR stimulation
title_sort	camkii induces permeability transition through drp1 phosphorylation during chronic β-ar stimulation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/193253a2af8e40d1889ff8f4ed1f6ac6
work_keys_str_mv	AT shangchengxu camkiiinducespermeabilitytransitionthroughdrp1phosphorylationduringchronicbarstimulation AT peiwang camkiiinducespermeabilitytransitionthroughdrp1phosphorylationduringchronicbarstimulation AT huiliangzhang camkiiinducespermeabilitytransitionthroughdrp1phosphorylationduringchronicbarstimulation AT guohuagong camkiiinducespermeabilitytransitionthroughdrp1phosphorylationduringchronicbarstimulation AT nicolasgutierrezcortes camkiiinducespermeabilitytransitionthroughdrp1phosphorylationduringchronicbarstimulation AT weizhongzhu camkiiinducespermeabilitytransitionthroughdrp1phosphorylationduringchronicbarstimulation AT yisangyoon camkiiinducespermeabilitytransitionthroughdrp1phosphorylationduringchronicbarstimulation AT rongtian camkiiinducespermeabilitytransitionthroughdrp1phosphorylationduringchronicbarstimulation AT wangwang camkiiinducespermeabilitytransitionthroughdrp1phosphorylationduringchronicbarstimulation
_version_	1718386458801209344

CaMKII induces permeability transition through Drp1 phosphorylation during chronic β-AR stimulation

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