CaMKII induces permeability transition through Drp1 phosphorylation during chronic β-AR stimulation

CaMKII induces permeability transition through Drp1 phosphorylation during chronic β-AR stimulation

β-adrenergic receptor signaling induces mitochondrial permeability transition pore (mPTP) opening. Here, Xuet al. show that this effect is mediated by phosphorylation of mitochondrial fission protein Drp1 by CamKII, which increases the frequency of transient mPTP opening.

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Detalles Bibliográficos
Autores principales: Shangcheng Xu, Pei Wang, Huiliang Zhang, Guohua Gong, Nicolas Gutierrez Cortes, Weizhong Zhu, Yisang Yoon, Rong Tian, Wang Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/193253a2af8e40d1889ff8f4ed1f6ac6
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